An AI Foundation Toxicology Model and Framework to Support Waiving a Second Species in Drug Safety Studies

Expected Outcome: Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to all of the following expected outcomes: Healthy people and in particular people at risk will benefit from microbiome tests and programmes that can discover and predict their transition to cancer before the onset of disease. People will have a better understanding of risks and will be enabled to address risks early by following treatments or adapting their lifestyles, including nutrition and other interventions. Physicians will be able to start cancer treatments earlier with a higher success rate. Policy makers and authorities will be enabled to develop and implement advanced and strategic programmes addressing cancer prevention. Scope: This topic will contribute to the achievement of the EU Cancer Mission’s objective to achieve better cancer prevention and early detection. The focus is on the development of validated microbiome tools, an assessment of predispositions, the comparison with other predictive tools and risk modelling approaches. Cancer often develops over several years and progresses silently before symptoms appear. Some cancers are…

Expected Outcome: Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to all of the following expected outcomes: Researchers of different disciplines use advanced multiscale Virtual Human Twins (VHTs) to expand the knowledge and understanding of cancer onset and progression Healthcare professionals and researchers have access to advanced VHT-based solutions that model cancer onset and progression over time, contributing to improve personalised treatments Researchers, healthcare professionals, innovators and citizens have access to cancer VHTs through the UNCAN.eu and the advanced Virtual Human Twin platforms Scope: Virtual human twins (VHTs) are digital representations and in-silico models of an individual’s health and disease at different levels of the human anatomy (e.g. cells, tissues, organs or organ systems) for the prevention, prediction, screening, diagnosis and treatment of a disease, as well as the selection and personalisation of intervention options [1] . The proposed topic will contribute to the EU Cancer Mission objectives by improving the accuracy of dynamic and multiscale VHTs to better understand cancer…

Expected Outcome: Successful proposals will contribute to the implementation of the EU initiative on Biotechnology and Biomanufacturing and the EU Life Sciences Strategy as well as the updated EU Bioeconomy Strategy, the upcoming EU Biotechnology Act and EU Circular Economy Act. Projects’ results are expected to contribute to the following expected outcomes: Full industrial scale biorefinery and related value chain(s) for the production of nutritional food ingredients. Resilience and strategic autonomy of EU food sectors via diversification of nutritional food ingredient sources. Increased environmental sustainability of food sectors (e.g. addressing issues like land use, water use, energy consumption, nitrogen cycle, other nutrients, etc.). Improved consumers awareness and acceptance of nutritional food ingredients from alternative sources, contributing to sustainable healthy diets. Scope: Human nutrition is a key area where the bio-based industries can play an important role in addressing the present societal and climate challenges. Considerable attention is given to the utilisation of alternative sources of proteins, fibres and oils/fats, due to the increasing world population…

Expected Outcome: Activities under this topic will support the EU Vision for Agriculture and Food , the EU Soil Strategy for 2030 , including the implementation of the EU Soil Monitoring and Resilience Directive, the EU Adaptation Strategy, the EU Water Resilience Strategy, and the forthcoming European Climate Adaptation Plan. Project results are expected to contribute to all the following expected outcomes: enhanced monitoring of soils at subnational level (e.g. regions and municipalities) leading to an overall improved soil resilience against extreme weather events, particularly in terms of soils’ capacity to withstand and recover from floods, droughts, heatwaves and broader temperature fluctuations; tailored soil management practices and solutions that improve soil health are adopted, promoting sustainable land management, enhancing food system resilience, including food security [1] , and strengthening the overall resilience of agricultural systems to current and future climate extreme events. Scope: Developing and scaling practical solutions to enhance soils’ resilience to extreme weather events is crucial for climate change adaptation. As extreme weather events like…

Expected Impact: The action under this topic is expected to achieve the following impacts and contribute to the following EU policies/initiatives: deliver innovative, early technology solutions that contribute to addressing strategic unmet public health needs across multiple therapy areas to improve prevention, early diagnosis, and treatment; leverage the unique network and scale of IHI JU members to create a pipeline to support innovative startups in the health industry, fully integrated into European initiatives in support of start-ups and entrepreneurship; drive early cross-sector health R&D and innovation to strengthen the European healthcare industry’s global competitiveness, contributing to the EU Industrial Strategy and Pharmaceutical Strategy objectives; create a sustainable network of European healthcare incubators to guide and support highly talented and innovative early-stage companies; harness digital health and data-sharing technologies (e.g., AI and big data) to enable interoperable health solutions, contributing to the European Health Data Space (EHDS) and improved evidence based care;- the action should generate a portfolio of early‑stage companies that have…

Expected Outcome: Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to the following expected outcomes: Through the European Cancer Patient Digital Centre (ECPDC), adolescent and young cancer patients and survivors as well as their caregivers have access to innovative tools and approaches to strengthen their mental health; Healthcare professionals have access to innovative tools to monitor and support the mental health of cancer patients and survivors as well as their caregivers Researchers and healthcare professionals have access and use reliable patient reported data to better understand the mental health needs of cancer patients and survivors and provide effective care. Scope: As part of its citizens engagement activities, the EU Cancer Mission has launched a dialogue with young cancer survivors, to better understand the specific needs and challenges faced during and after treatment. Mental health has been systematically highlighted as a major concern, stressing the importance of access to quality psychosocial support including through virtual, digital means along the different stages of the patient’s journey, at…

Expected Outcome: Project results are expected to contribute to the following outcomes: For supported postdoctoral fellows Increased set of research and transferable skills and competences, leading to improved employability and career prospects of MSCA postdoctoral fellows within academia and beyond; New mind-sets and approaches to R&I work forged through international, inter-sectoral and interdisciplinary experience; Enhanced networking and communication capacities with scientific peers, as well as with the general public that will increase and broaden the research and innovation impact. For participating organisations Increased alignment of working conditions for researchers in accordance with the principles set out in the European Charter for Researchers; Enhanced quality and sustainability of research training and supervision; Increased global attractiveness, visibility and reputation of the participating organisation(s); Stronger R&I capacity and output among participating organisations; better transfer of knowledge; Regular feedback of research results into teaching and education at participating organisations. Scope: Fellowships will be provided to excellent researchers…

Specific Challenge: The “EU Award for Gender Equality Champions” is a recognition prize scheme designed as a booster and a complement to the Gender Equality Plans (GEP) eligibility criterion in Horizon Europe [1] , and as a tool for advancing inclusive GEPs and policies within the framework of the ERA Policy Agenda. Expected Outcomes : Recognition of organisations with the most significant impact resulting from the implementation of their GEP, serving as role models for others; Strengthened gender equality and inclusiveness in the European Research Area. The Prize will be awarded to four organisations, and contestants can apply to one of the following three prize categories: Sustainable Gender Equality Champions: Organisations that can demonstrate a significant and sustained record of activity and a high level of achievement through the implementation of their GEP(s); Newcomer Gender Equality Champions: Organisations without a sustained record of activity in gender equality that have recently completed the implementation of their first GEP and can demonstrate the most progress achieved through its implementation; Inclusive Gender Equality Champions: Organisations that have…

Specific Challenge: The “EU Award for Gender Equality Champions” is a recognition prize scheme designed as a booster and a complement to the Gender Equality Plans (GEP) eligibility criterion in Horizon Europe [1] , and as a tool for advancing inclusive GEPs and policies within the framework of the ERA Policy Agenda. Expected Outcomes : Recognition of organisations with the most significant impact resulting from the implementation of their GEP, serving as role models for others; Strengthened gender equality and inclusiveness in the European Research Area. The Prize will be awarded to four organisations, and contestants can apply to one of the following three prize categories: Sustainable Gender Equality Champions: Organisations that can demonstrate a significant and sustained record of activity and a high level of achievement through the implementation of their GEP(s); Newcomer Gender Equality Champions: Organisations without a sustained record of activity in gender equality that have recently completed the implementation of their first GEP and can demonstrate the most progress achieved through its implementation; Inclusive Gender Equality Champions: Organisations that have…

Specific Challenge: The “EU Award for Gender Equality Champions” is a recognition prize scheme designed as a booster and a complement to the Gender Equality Plans (GEP) eligibility criterion in Horizon Europe [1] , and as a tool for advancing inclusive GEPs and policies within the framework of the ERA Policy Agenda. Expected Outcomes : Recognition of organisations with the most significant impact resulting from the implementation of their GEP, serving as role models for others; Strengthened gender equality and inclusiveness in the European Research Area. The Prize will be awarded to four organisations, and contestants can apply to one of the following three prize categories: Sustainable Gender Equality Champions: Organisations that can demonstrate a significant and sustained record of activity and a high level of achievement through the implementation of their GEP(s); Newcomer Gender Equality Champions: Organisations without a sustained record of activity in gender equality that have recently completed the implementation of their first GEP and can demonstrate the most progress achieved through its implementation; Inclusive Gender Equality Champions: Organisations that have…