Environmental Health Sciences Core Centers Program (P30 Clinical Trials Optional)

The North American Wetlands Conservation Act (NAWCA) U.S. Standard grants are competitive, matching grants that support public-private partnerships carrying out projects in the U.S. that involve long-term protection, restoration, and/or enhancement of wetlands and associated uplands habitats for the benefit of all wetlands-associated migratory birds. A 1 to 1 match to grant ratio is a requirement. For US Standard scoring criteria (page 33 of US Standard Instructions) and US Eligibility criteria, visit: https://www.fws.gov/service/north-american-wetlands-conservation-act-nawca-us-standard-grantsTo view previously successful awarded NAWCA US Standard Projects, visit NAWCA's external facing database to query for your viewing: https://www.fws.gov/grantsum/

The Highlands Conservation Act Program (HCA) is administered by the US Fish and Wildlife Service (Service) to assist Connecticut, New Jersey, New York, and Pennsylvania in the protection of land and natural resources in the Highlands Region. HCA grants support land conservation projects in which a State, County, or Municipal entity acquires land or an interest in land from a willing seller to conserve resources of high conservation value.Governors of the four Highlands States may submit proposals for up to 50% of the total cost of land conservation projects in the Highlands Region.Funding appropriated under the HCA is typically divided into two separate categories – Base and Competitive. Eligible applicants may submit requests for the Competitive Funding Round in response to this Notice of Funding Opportunity. A separate Notice of Funding Opportunity will be posted for Base Funds. A project may not be proposed for funding in both funding opportunities.More information on the HCA program is available at www.fws.gov/program/highlands-conservation-act-grant

The Bureau of Reclamation"s Desalination and Water Purification Research (DWPR) Program aims to increase water supplies by reducing the costs, energy requirements, and other barriers to adoption of treating impaired water for beneficial uses. This NOFO invites proposals from eligible applicants to conduct innovative laboratory and pilot-scale water treatment research. Strong applications will demonstrate widespread applicability and benefits of the proposed research and provide a pathway for technology commercialization. This initiative supports the Bureau of Reclamation's mission to manage, develop, and protect water and related resources in an environmentally and economically sound manner in the interest of the American public by providing water managers with new and innovative technologies and approaches to develop additional water resources and increase water supply flexibility. The DWPR Program demonstrably advances Trump administration priorities, such as those identified in Presidential Executive Order 14154 (January 20, 2025): Unleashing American Energy (E.O. 14154) and Secretarial Order 3418, and aligns with other priorities and requirements, such as those identified in Presidential Executive Order 14332 (August 7, 2025): Improving Oversight in Federal Grantmaking (E.O. 14332).

The BLM Wildlife Program, including the Sage-Grouse Conservation Program, implements statutory authorities to address the management of wildlife resources on the public lands for the social and economic well-being of all Americans. Specific BLM Wildlife Program priorities include: 1. protection, maintenance, and development of wildlife habitat; 2. wildlife reintroduction and propagation; 3. field study programs involving wildlife; 4. law enforcement; 5. educational programs; 6. toxicity/mortality investigations and monitoring; 7. wildlife damage management; 8. management activities affecting wildlife and their habitat. The BLM Wildlife Program works with partner organizations to meet the goals above on national, regional, or state-scales by:Implementing management actions such as the implementation of grassland, shrubland, forest, riparian, and other plant community treatments that fulfill statutory and legal requirements, align with approved land use plans, and support habitat objectives for priority wildlife species, including upland game, waterfowl, big game, non-game, and watchable wildlife.Collaborating with state fish and wildlife agencies, and other partners, on efforts that conserve and restore habitats in priority winter ranges and migration corridors for elk, deer, and pronghorn on BLM-managed lands, in support of Secretary's Order 3362 "Improving Habitat Quality in Western Big-Game Winter Range and Migration Corridors."Collecting and analyzing monitoring and inventory data on priority species and habitats including terrestrial and aquatic plant communities, to assess status and trends, inform plan implementation, improve management effectiveness, and support Administration priorities.Enhancing efficiency by integrating and sharing coordinated wildlife and habitat monitoring data to streamline decision-making and management actions.Coordinating with state agencies and other partners to support recovery and augmentation of species identified in State Wildlife Action Plans through proactive, voluntary, on-the-ground collaborative conservation efforts.Collaborating with state agencies and other partners under the Sikes Act to develop and implement fish and wildlife conservation and habitat improvement projects, including grassland, shrubland, forest, riparian, and other plant community treatments.Developing and implementing activity plans and Habitat Management Plans (HMPs) in partnership with state agencies and other partners to address habitat needs for regionally important species, including big game, waterfowl, upland game, and non-game species. Providing wildlife habitat management training opportunities to support effective plan implementation, meet legal mandates, and advance agency and Administration priorities.The following Administration priorities are applicable to this program:Executive Order (EO) 13443, Facilitation of Hunting Heritage and Wildlife ConservationEO 14192 - Unleashing Prosperity Through DeregulationEO 14303 - Restoring Gold Standard ScienceEO 14225 - Immediate Expansion of American Timber Production EO 14313 - Establishing the President's Make America Beautiful Again CommissionSO 3356 - Hunting, Fishing, Recreational Shooting, and Wildlife Conservation Opportunities and Coordination with States, Tribes, and TerritoriesSO 3362 - Improving Habitat Quality in Western Big-Game Winter Range and Migration CorridorsSO 3421 - Achieving Prosperity through DeregulationSO 3447 - Expanding Hunting and Fishing Access, Removing Unnecessary Barriers, and Ensuring Consistency Across the Department of the Interior Lands and WatersOne Big Beautiful Act, H.R. 1, 119th Cong. (2025)

The Highlands Conservation Act Program (HCA) is administered by the US Fish and Wildlife Service (Service) to assist Connecticut, New Jersey, New York, and Pennsylvania in the protection of land and natural resources in the Highlands Region. HCA grants support land conservation projects in which a State, County, or Municipal entity acquires land or an interest in land from a willing seller to conserve resources of high conservation value.Governors of the four Highlands States may submit proposals for up to 50% of the total cost of land conservation projects in the Highlands Region.Funding appropriated under the HCA is typically divided into two separate categories – Base and Competitive. Eligible applicants may submit requests for the Base Funding Round in response to this Notice of Funding Opportunity. A separate Notice of Funding Opportunity will be posted for Competitive Funds. A project may not be proposed for funding in both funding opportunities.More information on the HCA program is available at www.fws.gov/program/highlands-conservation-act-grant

The Competitive State Wildlife Grant (C-SWG) Program provides Federal cost-sharing awards that help the State, Territory, and District of Columbia fish and wildlife agencies and their regional associations design and implement proactive conservation programs benefiting wildlife and their habitats. Proactive approaches to conservation help these recipients and their conservation partners avoid more prescriptive Federal regulatory requirements associated with species listing under the Endangered Species Act.The C-SWG Program prioritizes implementation of conservation actions described in the State and Territory Wildlife Action Plans (Plans). Projects must benefit one or more species of greatest conservation need or their habitats as identified in the Plans.This announcement provides complete information on preparing and submitting an application, including details on award tiers, partnership requirements, and the maximum Federal share of an award. The award tiers and related requirements are intended to encourage partnerships dedicated to cross-jurisdictional conservation efforts supporting landscape-scale conservation.

The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges. The purpose of this NOFO is to solicit applications for the creation of a Validation Center to serve as a dedicated hub for the comprehensive evaluation and characterization of AI-enabled, image-based, multimodal CDS tools developed by the PRIMED-AI Consortium, to ensure these tools are reliable, reproducible, and generalizable. The Validation Center will focus on verification, validation, interoperability, and uncertainty quantification to comprehensively characterize performance of the CDS tools developed by the program. The core functions of the Validation Center will involve the systematic validation of PRIMED-AI Consortium deliverables, including those emerging from award recipients under the Playbook, Data-to-Model Academic-Industrial Partnerships, and Model-to-Clinic NOFOs.

The purpose of this Notice of Funding Opportunity (NOFO) is to support the next 5-year award period of the Clinician-Scientist Transdisciplinary Aging Research Coordinating Center (Clin-STAR CC), whose mission is to serve as a national resource for clinician-investigators across specialties and disciplines who are focusing their careers on aging research. This NOFO intends to build upon NIA's substantial investments to foster the development of clinician-scientists across specialties and disciplines. The specific goals of this initiative are to convey scientific and research knowledge on aging research; foster networking and collaboration between clinician-scientist leaders in aging research and clinician-investigators across specialties and disciplines who wish to focus on aging research; provide mentoring and career development support for emerging clinician-scientists committed to pursuing aging research in their clinical specialty or discipline; and advance interdisciplinary research projects in aging. Ultimately, the Clin-STAR CC is intended to provide a multi-faceted national research platform leading to improved patient-centered care for older adults across specialties and disciplines.

This Notice of Funding Opportunity (NOFO) invites a single cooperative agreement application for the Resource Center for the Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D). The purpose of CaRe-T1D is to support innovative, discovery and mechanistic research through the study of human cardiovascular (CV) tissue. This research seeks to better understand cardiovascular disease (CVD) in type 1 diabetes, highlight differences compared to type 2 diabetes, and ultimately guide the development of therapies to treat this major cause of morbidity and mortality for individuals with type 1 diabetes. To achieve these goals, the Resource Center will expand the CaRe-T1D biorepository of human CV tissue, further develop the data commons for data sharing and for artificial intelligence (AI) tools, coordinate the research activities of the investigative teams in the CaRe-T1D consortium, and make CaRe-T1D resources accessible to the broader research community. This NOFO is associated with the Special Diabetes Program (https://www.niddk.nih.gov/about-niddk/research-areas/diabetes/type-1-diabetes-special-statutory-funding-program/about-special-diabetes-program) which funds research on the prevention, treatment, and cure of type 1 diabetes and its complications, including unique, innovative, and collaborative research consortia and clinical trials networks.This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invite application(s) from eligible organization(s) to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on developing a comprehensive and cohesive understanding of cancer metastasis. Towards this goal, the NCI will support U54 Specialized Centers that together will continue to serve as the hub of the Metastasis Research Network (MetNet). Each MetNet Center should propose an overarching scientific theme that will be pursued through two or three scientific inter- and multidisciplinary basic research projects. The projects should use integrative system level approaches to elucidate and integrate a mechanistic understanding of the non-linear, dynamic, and emergent processes in metastasis. Overarching themes should encompass the interplay between at least two central elements in the metastatic process such as early dissemination, cellular, soluble and/or physical microenvironment crosstalk, dormancy, or mechanisms of responses by metastatic cells to therapies. Studies on all types of cancer are welcome, including rare and pediatric metastatic cancers.Research proposed by MetNet Centers is expected to advance our understanding towards a more comprehensive appreciation of metastasis as a whole body, systems-level problem.