Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)

Questions regarding this Training and Employment Guidance Letter (TEGL) may be emailed to Daniela Petchik, Grants Management Specialist at petchik.daniela.m@dol.gov and Brinda Ruggles, Grant Officer at ruggles.brinda@dol.gov. We encourage prospective applicants and interested parties to use the Grants.gov subscription option to register for future updates provided for this particular TEGL.

The purpose of this Funding Opportunity Announcement is to invite proposals for funding from Tribal Colleges and Universities, Tribal Serving Institutions, Community Colleges on or near Tribal Lands, and other Trade Schools on or near Tribal Lands interested in providing innovative hands-on, in-person manufacturing training and technical assistance through rapid reskilling of employees for 8(a) and HUBZone eligible small businesses , under the U.S. Small Business Administration's Empower to Grow Program (formerly known as 7(j) Management and Technical Assistance Program).

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for projects to expand, improve, or transform the utility of mammalian cancer and tumor models for translational research. With this NOFO, the NCI intends to encourage submission of projects devoted to demonstrating that mammalian models or their derivatives used for translational research are robust representations of human biology, are appropriate to test questions of clinical importance, and provide reliable information for patients' benefit. These practical goals contrast with the goals of many mechanistic, NCI-supported R01 projects that employ mammals, or develop and use mammalian cancer models, transplantation tumor models, or models derived from mammalian or human tissues or cells for hypothesis-testing, non-clinical research. Among many other possible endeavors, applicants in response to this FOA could propose demonstrations of how to overcome translational deficiencies of mammalian oncology models, define new uses of mammalian models or their genetics for unexplored translational challenges, advance standard practices for use of translational models, test approaches to validate and credential models, or challenge current practices for how models are used translationally

The Secretary of Labor, through MSHA, may award grants to State, Tribal, and Territorial Governments (including the District of Columbia, the Commonwealth of Puerto Rico, the Virgin Islands, American Samoa, Guam, and the Commonwealth of the Northern Mariana Islands) to assist them in developing and enforcing State mining laws and regulations, improve State workers’ compensation and mining occupational disease laws and programs, and improve safety and health conditions in the nation’s mines through Federal-State coordination and cooperation.   MSHA encourages State training programs to prioritize health and safety training for new and small mining operations. MSHA also encourages grant recipients to address, in their training and education programs, contract employee safety and occupational health hazards, powered haulage and mobile equipment safety, mine emergency preparedness, mine rescue, electrical safety, training for new and inexperienced miners, managers and supervisors performing mining tasks, and falls from heights. Applicants are encouraged, where applicable, to support the President’s goals of increasing the discovery and mining of critical minerals, by developing or creating training and compliance assistance programs to assist operators extracting critical minerals, including coal. The President has declared a National Energy Emergency to discover and mine critical minerals. Executive Order (EO) 14156, Declaring a National Energy Emergency (2025). To increase the response, on March 20, 2025, the President also directed the appropriate federal agencies to take immediate actions to increase mineral production. EO 14241, Immediate Measures To Increase American Mineral Production (2025). In response, the mining industry may experience increases in the reopening of idled mines and developing new mines in the search for these critical minerals. With these increases, new and innovative programs to train new miners or retrain miners for extracting specific critical minerals are vital. The Department of Energy (DOE) published a list of critical materials for energy, Federal Register :: Notice of Final Determination on 2023 DOE Critical Materials List . On May 29, 2025, DOE added metallurgical coal used for steelmaking to the Critical Material list, 90 Federal Register 22711 (2025). The Department of Interior, U.S. Geological Survey, in consultation with other federal agencies published the list of critical minerals, What are Critical Minerals? | U.S. Geological Survey (usgs.gov) . Moreover, on April 8, 2025, the President amended EO 14241 and declared coal a critical mineral. EO 14261, Reinvigorating America’s Beautiful Clean Coal Industry and Amending EO 14241 (2025). On January 12, 2026, the President extended the National Energy Emergency declared in EO 14156 for another year. Notice of January 12, 2026, Continuation of the National Emergency with Respect to Energy, 91 Federal Register 1667-68 (2026). 

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to encourage individuals who have not had substantial biomedical research experience, or who have the potential to significantly benefit from additional biomedical research experience to pursue further studies or careers in research. To accomplish the stated over-arching goal, this NOFO will support educational activities with a primary focus on: (1) Research Experiences, (2) Curriculum or Methods Development and (3) Outreach. The NCI’s mission is to conduct and support research, training, health information dissemination, and other programs concerning cancer. This funding opportunity seeks to facilitate educational activities that encourage students to become knowledgeable about cancer and available to focus on cancer later in their careers. To promote broad interest in pursuing a career in biomedical research via early intervention strategies, the NCI Youth Enjoy Science (YES) Program will support efforts to create and maintain an institutional program to engage grades 6-12 and/or undergraduate students in cutting edge cancer research experiences. The proposed institutional programs may also provide research experiences for the grade 6-12 teachers and undergraduate faculty members. The goals are to inspire interest in biomedical sciences, help envision research as a career path, and strengthen practical research and career skills. In alignment with these goals, institutions may develop unique programs that capitalize on their research strengths and are responsive to their target populations.

The U.S. Department of State's Embassy Cairo announces an open competition to identify a qualified provider organization to support the placement and administration of two English Language Fellows (ELFs) in Egypt for a 28-month program period. This program addresses a critical operational need: the successful implementation of the English Language Fellows program requires an international or local partner with expertise in human resources management, visa facilitation, financial administration, and logistical support to ensure Fellows can focus on their educational mission while receiving comprehensive administrative support throughout their assignment. The English Language Fellows program brings American English language teaching professionals to Egypt to work with local institutions, train Egyptian English teachers, develop curriculum, and strengthen English language education capacity. These Fellows serve as cultural ambassadors while providing technical expertise in modern TESOL methodologies, educational technology, and professional development. The success of this program depends on seamless administrative support that allows Fellows to maximize their impact on Egyptian educators and students. The selected provider organization will serve as the primary administrative partner responsible for: (1) recruiting, vetting, and selecting two qualified American English Language Fellows in coordination with U.S. Embassy Cairo; (2) managing all financial aspects including monthly salary disbursement, housing allowance payments, and reimbursement for approved expenses; (3) facilitating visa issuance and work permit processes in coordination with Egyptian authorities and Embassy staff; (4) providing ongoing logistical support including housing arrangements, local orientation, and problem-solving assistance; (5) ensuring compliance with U.S. government regulations, Egyptian labor laws, and program requirements; and (6) maintaining regular communication with Embassy staff and Fellows to address issues promptly and ensure program success. This program directly advances the Trump Administration's core foreign policy objectives by making America safer, stronger, and more prosperous through strategic educational partnerships. By building English language capacity in Egypt through American expertise, the program creates lasting partnerships that facilitate trade, cultural exchange, and mutual understanding—all essential components of a prosperous and secure bilateral relationship in a strategically vital region. The Fellows program represents a cost-effective model for projecting American values and expertise while building sustainable institutional capacity in partner nations. Eligible applicants include educational organizations, non-governmental organizations, human resources firms, and institutions with demonstrated experience in personnel management, visa facilitation, financial administration, and support services for international professionals. The selected organization must have the knowledge of local regulatory requirements, and capacity to provide responsive support to American professionals working in the Egyptian context. Success will be measured through: timely recruitment and placement of two qualified Fellows (both Fellows in-country and working within 60 days of program start), effective financial management (100% on-time salary and allowance payments with accurate expense reimbursement), successful visa facilitation (all required permits obtained within regulatory timeframes), responsive logistical support (housing secured, orientation provided, issues resolved within 48 hours), and overall Fellow satisfaction (90% of Fellows rating provider support as "good" or "excellent" in end-of-program evaluations). This strategic partnership will enable the English Language Fellows program to achieve maximum impact on Egypt's English language education sector while ensuring American professionals receive the administrative support necessary to succeed in their educational mission. The provider organization will serve as a critical bridge between U.S. government priorities, American Fellows' needs, and Egyptian institutional requirements.

The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges. The purpose of this NOFO is to solicit applications for the creation of a Validation Center to serve as a dedicated hub for the comprehensive evaluation and characterization of AI-enabled, image-based, multimodal CDS tools developed by the PRIMED-AI Consortium, to ensure these tools are reliable, reproducible, and generalizable. The Validation Center will focus on verification, validation, interoperability, and uncertainty quantification to comprehensively characterize performance of the CDS tools developed by the program. The core functions of the Validation Center will involve the systematic validation of PRIMED-AI Consortium deliverables, including those emerging from award recipients under the Playbook, Data-to-Model Academic-Industrial Partnerships, and Model-to-Clinic NOFOs.

In response to a longstanding congressional mandate (P.L. 98-619, Departments of Labor, Health and Human Services, and Education and Related Agencies Appropriation Act, 1985), NIMHD invites applications from eligible institutions to establish a national coordinating center (CC) for the Research Centers in Minority Institutions (RCMIs) initiative. The RCMI CC will coordinate activities across funded RCMI U54 Centers, prospectively evaluate the overall RCMI program, and serve as a national resource to help these centers achieve their primary goals. The RCMI CC will be responsive to requests generated by RCMI site key personnel, NIMHD, NIH, the scientific community, and the general public.

This Notice of Funding Opportunity (NOFO) invites a single cooperative agreement application for the Resource Center for the Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D). The purpose of CaRe-T1D is to support innovative, discovery and mechanistic research through the study of human cardiovascular (CV) tissue. This research seeks to better understand cardiovascular disease (CVD) in type 1 diabetes, highlight differences compared to type 2 diabetes, and ultimately guide the development of therapies to treat this major cause of morbidity and mortality for individuals with type 1 diabetes. To achieve these goals, the Resource Center will expand the CaRe-T1D biorepository of human CV tissue, further develop the data commons for data sharing and for artificial intelligence (AI) tools, coordinate the research activities of the investigative teams in the CaRe-T1D consortium, and make CaRe-T1D resources accessible to the broader research community. This NOFO is associated with the Special Diabetes Program (https://www.niddk.nih.gov/about-niddk/research-areas/diabetes/type-1-diabetes-special-statutory-funding-program/about-special-diabetes-program) which funds research on the prevention, treatment, and cure of type 1 diabetes and its complications, including unique, innovative, and collaborative research consortia and clinical trials networks.This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invite application(s) from eligible organization(s) to apply. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.

The purpose of this Notice of Funding Opportunity (NOFO) is to support the next 5-year award period of the Clinician-Scientist Transdisciplinary Aging Research Coordinating Center (Clin-STAR CC), whose mission is to serve as a national resource for clinician-investigators across specialties and disciplines who are focusing their careers on aging research. This NOFO intends to build upon NIA's substantial investments to foster the development of clinician-scientists across specialties and disciplines. The specific goals of this initiative are to convey scientific and research knowledge on aging research; foster networking and collaboration between clinician-scientist leaders in aging research and clinician-investigators across specialties and disciplines who wish to focus on aging research; provide mentoring and career development support for emerging clinician-scientists committed to pursuing aging research in their clinical specialty or discipline; and advance interdisciplinary research projects in aging. Ultimately, the Clin-STAR CC is intended to provide a multi-faceted national research platform leading to improved patient-centered care for older adults across specialties and disciplines.