Alternatives to Impact Monitoring and Assessment Framework for the Chips JU

Expected Impact: The action under this topic is expected to achieve the following impacts: Accelerate EU access to more cost-effective interventions in an increasingly ageing population by identifying personalised treatment approaches for elderly-onset immune diseases. Decrease disease risk later in life by defining specific prevention strategies based on ageing biomarkers and risk factors. Halt age-associated disease exacerbation by the identification of predictive and digital biomarkers that can stratify patients for early intervention. Improve quality of life for healthy individuals and patients by preventing further health decline, avoiding escalating care costs, and properly stratifying individuals earlier in the diagnostic pathway. Accelerate adoption of innovative diagnostic, preventative, and therapeutic strategies, strengthening the EU’s position as a healthcare innovator. Evaluate digital biomarker as potential regulatory endpoints in the ultimate goal to develop medicines for ‘healthy ageing’. Integrate fragmented research efforts by bringing together health industry sectors and stakeholders to develop clinical and multi-omics data integration capabilities. Enable new…

Expected Outcome: This action will establish a strategic European initiative to develop scalable, modular, and interoperable photonic quantum computing platforms. Proposals for this topic are expected to address and provide credible solutions to at least two major technical roadblocks currently limiting the advancement of photonic quantum computing such as: The lack of deterministic, high-efficiency photonic entanglement and loss-tolerant architectures suitable for fault-tolerant scaling The absence of a standardised, integrated control stack combining photonic hardware, firmware, and system software with reliable benchmarking across platforms Project results are expected to contribute to the following expected outcomes: By 2028, demonstration of a photonic NISQ processor with ≥100 photonic qubits, integrating deterministic single-photon sources, low-loss waveguides, on-chip detectors, and a firmware stack (scheduler, controller, compiler), validated via hardware-agnostic benchmarks and hybrid photonic-HPC applications demonstrating classical-quantum crossover By 2030, delivery of a full-stack, high-connectivity photonic quantum computer, with modular scalability, integrated…

Expected Impact: The action under this topic is expected to achieve the following impacts and contribute to the following EU policies/initiatives: deliver innovative, early technology solutions that contribute to addressing strategic unmet public health needs across multiple therapy areas to improve prevention, early diagnosis, and treatment; leverage the unique network and scale of IHI JU members to create a pipeline to support innovative startups in the health industry, fully integrated into European initiatives in support of start-ups and entrepreneurship; drive early cross-sector health R&D and innovation to strengthen the European healthcare industry’s global competitiveness, contributing to the EU Industrial Strategy and Pharmaceutical Strategy objectives; create a sustainable network of European healthcare incubators to guide and support highly talented and innovative early-stage companies; harness digital health and data-sharing technologies (e.g., AI and big data) to enable interoperable health solutions, contributing to the European Health Data Space (EHDS) and improved evidence based care;- the action should generate a portfolio of early‑stage companies that have…

Expected Impact: The action under this topic is expected to achieve the following impacts: Faster and more informed decision-making through the use of an AI-driven NAM (AI Foundation Toxicology Model) and increased efficiency through rapid processing of vast amounts of data [1] . Increased consistency and standardisation in a NAM-based approach, specifically an AI model, used by industry in the efficient development, testing and production of safe and effective innovative health technologies, improving industrial competitiveness. Regulatory adoption of a NAM-enabled second species waiver model (AI Foundation Toxicology Model) and weight-of-evidence framework, in line with recommendations and more consistent global decision-making on waiving second species testing. Reduction in animal use, accelerated timelines and lower costs, enhancing the competitiveness of the European health industry through economical and ethical benefits. Improved public health as patients will benefit from safe and effective medicines developed faster using validated NAMs. The action is expected to contribute to the EU Directive (2010/63/EU) [2] on the protection of animals used for scientific purposes and…

Expected Outcome: Excellent capacities in research management are essential for institutions and national R&I systems to enhance their research excellence and capitalize on their R&I activities in a knowledge-based economy and society. The Research Management Facility aims at providing institutions in Widening countries that want to establish or upgrade their research management capacities with tailored support. The Research Management Facility also advises on an implementation strategy to introduce changes in the institutional set-up, in line with the ERA priorities. However, the action does not provide support for the implementation of the strategy. Strong research management ensures effective grant acquisition, resource allocation, compliance with funding regulations, and strategic planning. It supports high-quality research by streamlining administrative processes, facilitating interdisciplinary collaborations, attracting and retaining international high-profile researchers, and optimizing the use of research infrastructures. Proposals are expected to contribute to the following outcomes: Encourage the establishment of stronger research management capacities in Widening…

Expected Outcome: This topic aims at supporting activities that are enabling or contributing to the Climate-Neutral and Smart Cities Mission by accelerating the transition towards climate neutrality in cities. To this end, project results are expected to contribute to all of the following expected outcomes: Cities involved in this action advance in achieving their climate neutrality targets, reducing greenhouse gas and air pollutant emissions by improving energy efficiency in urban and sub-urban public transport systems , complemented by urban mobility service car fleets – taxis, ride-hailing, car sharing and other active and shared mobility services . Comprehensive inventory and assessment of existing instruments and measures to foster electrification and attractiveness of urban and sub-urban public transport systems , urban mobility service car fleets and shared mobility, accompanied by targeted guidance for responsible authorities, operators and providers through integration of measures to improve energy efficiency in public transport and new shared mobility services. Upscaling of innovative and sustainable integrated mobility solutions , identifying gaps and shortcomings in…

Expected Outcome: This topic aims at directly engaging and supporting relevant public authorities with mapping at large scale the conditions of marine habitats needed for implementing the Nature Restoration Regulation and for achieving one or several objectives of the Mission Restore our Ocean and Waters [1] . The direct involvement of relevant authorities and stakeholders in the consortium is strongly encouraged. Project results are expected to contribute to all the following expected outcomes: Member States have the capacity and access to tried and tested solutions to complete the mapping of the distribution and condition of coastal and marine habitats listed in Annex II of the Nature Restoration Regulation [2] (NRR) in the waters under their jurisdiction, which is needed to fulfil the obligations under Article 5 of the NRR within the deadlines, and obligations under the Marine Strategy Framework Directive (MSFD) and the Birds and Habitats Directive (BHD); Substantial areas of habitats have been mapped and their condition assessed. Priority should be given to Groups 1-6 of Annex II, followed by Group 7 of Annex II [3] , in line with applicable deadlines; Member States have the…

Expected Outcome: Successful proposals will contribute to the implementation of the EU initiative on Biotechnology and Biomanufacturing and the EU Life Sciences Strategy as well as the updated EU Bioeconomy Strategy, the upcoming EU Biotechnology Act and EU Circular Economy Act. Projects’ results are expected to contribute to the following expected outcomes: Full industrial scale biorefinery and related value chain(s) for the production of nutritional food ingredients. Resilience and strategic autonomy of EU food sectors via diversification of nutritional food ingredient sources. Increased environmental sustainability of food sectors (e.g. addressing issues like land use, water use, energy consumption, nitrogen cycle, other nutrients, etc.). Improved consumers awareness and acceptance of nutritional food ingredients from alternative sources, contributing to sustainable healthy diets. Scope: Human nutrition is a key area where the bio-based industries can play an important role in addressing the present societal and climate challenges. Considerable attention is given to the utilisation of alternative sources of proteins, fibres and oils/fats, due to the increasing world population…

Expected Outcome: Activities under this topic will help progress towards the objectives and targets of the Mission Soil and the EU Soil Strategy for 2030 . Activities should also contribute to the implementation of the Soil Monitoring and Resilience Directive after its adoption. Project results are expected to contribute to all the following expected outcomes: enhanced adoption of impactful sustainable soil management solutions and strategies supported by AI-powered decision support systems by land managers; harmonised, standard, robust, interoperable and accessible methods, protocols and logical architecture for long-term field experiments (LTEs) data collection and integration (including with other datasets) are in place; scientists, policymakers, and land managers gain enhanced access to comprehensive, high-quality soil data, enabling better research, informed decision-making, and effective land management practices. Scope: Long-term field experiments (LTEs) can be defined as “agricultural experiments for monitoring soil and crop properties under changing climate conditions and different management with a minimum duration of 20 years” [1] , [2] . LTEs are typically owned or…

Expected Outcome: This topic aims at directly engaging and supporting public authorities and other relevant socio-economic actors (e.g. farmers, landowners, aquaculture producers, tourist operators, fishers, businesses, water management authorities) in addressing aquatic pollution and biodiversity loss, thereby demonstrating and accelerating the transitions needed for achieving one or several objectives of the Mission “Restore our Ocean and Waters”. The direct involvement of relevant authorities and stakeholders in the consortium is strongly encouraged. Project results are expected to contribute to all the following expected outcomes: Member States and Associated Countries are provided with cost-effective solutions to reach the targets of the Water Framework and the Marine Strategy Framework directives, the Urban Wastewater Treatment Directive, and the EU strategy for sustainable chemicals and are enabled to take action to implement the targets of the EU biodiversity, climate adaptation and water resilience strategies for 2030 and the EU zero pollution action plan; National, regional and local authorities and other relevant stakeholders have access to and are supported in…

Expected Outcome: Proposals are expected to contribute to all following points: The projects must fulfil the performance targets, at the cell and system level, corresponding to the specific targeted application, to be specified in the proposal. Appropriate KPI must be defined for the energy density (volumetric and gravimetric), Power density and C-rate, number of cycles and cost defined under operational conditions. Boost EU competitiveness in next-generation battery technologies for mobility applications. Develop pilot manufacturing capability for next generation lithium-based batteries. Strengthen the EU battery value chain, including new manufacturing equipment, automation, and scalable production processes. Advance the understanding of next-generation battery interfaces at an industrial scale, ensuring manufacturability, durability, and cost-effectiveness. In the case of aviation, the battery requirements should be compatible at minimum with EASA CS.23 (level 4), CS.27 and preferably with CS.25 categories. Scope: This topic will support the scaling-up of next generation (i.e., beyond generation 3) lithium-based batteries (e.g., semi and all-solid state, generation5) from cell…

Expected Outcome: Successful proposals will contribute to the Chemicals Strategy for Sustainability and Ecodesign for Sustainable Products Regulation, the Chemical Industry Action Plan, the Clean Industrial Deal as well as the Horizon Europe Mission "Restore our Ocean and Waters by 2030" in particular to Objective 2: "Prevent and eliminate pollution of our oceans, Seas and waters". Projects results are expected to contribute to the following expected outcomes: Full industrial scale biorefinery and related value chain(s) to produce SSbD bio-based solutions for home and/or personal care sector with significantly improved sustainability. Wider availability of bio-based products in home and/or personal care sector meeting both regulatory standards and technical performance requirements. Increased consumer/end user acceptance of bio-based solutions, facilitating market uptake. Contribution to the EU strategic autonomy, resilience and competitiveness, reducing the fossil feedstock dependence for chemicals production and minimising biomass imports dependencies. Scope: The home and personal care sector, including fast-moving consumer goods (FMCG) and cosmetics, is a key industry where…