Pragmatic clinical trials to optimise immunotherapeutic interventions for patients with refractory cancers

Expected Outcome: Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to all of the following expected outcomes: Healthy people and in particular people at risk will benefit from microbiome tests and programmes that can discover and predict their transition to cancer before the onset of disease. People will have a better understanding of risks and will be enabled to address risks early by following treatments or adapting their lifestyles, including nutrition and other interventions. Physicians will be able to start cancer treatments earlier with a higher success rate. Policy makers and authorities will be enabled to develop and implement advanced and strategic programmes addressing cancer prevention. Scope: This topic will contribute to the achievement of the EU Cancer Mission’s objective to achieve better cancer prevention and early detection. The focus is on the development of validated microbiome tools, an assessment of predispositions, the comparison with other predictive tools and risk modelling approaches. Cancer often develops over several years and progresses silently before symptoms appear. Some cancers are…

Expected Outcome: Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to all of the following expected outcomes: Researchers of different disciplines use advanced multiscale Virtual Human Twins (VHTs) to expand the knowledge and understanding of cancer onset and progression Healthcare professionals and researchers have access to advanced VHT-based solutions that model cancer onset and progression over time, contributing to improve personalised treatments Researchers, healthcare professionals, innovators and citizens have access to cancer VHTs through the UNCAN.eu and the advanced Virtual Human Twin platforms Scope: Virtual human twins (VHTs) are digital representations and in-silico models of an individual’s health and disease at different levels of the human anatomy (e.g. cells, tissues, organs or organ systems) for the prevention, prediction, screening, diagnosis and treatment of a disease, as well as the selection and personalisation of intervention options [1] . The proposed topic will contribute to the EU Cancer Mission objectives by improving the accuracy of dynamic and multiscale VHTs to better understand cancer…

Expected Outcome: the proposals under this call are expected to address one or more of the following subjects : • Enhanced personalized monitoring, care and treatments, focusing on the development of highly customized healthcare solutions, including the required research and diagnostic tools, tailored to individual needs, covering various scenarios such as chronic disease management, physiotherapy, precision diagnosis, personalized medicine/treatment, pre- and postoperative care, and daily assistance in homes and common spaces. It also targets effective management of chronic diseases and elderly care through personalized monitoring and interventions facilitated by advanced sensor technologies and edge-to-cloud solutions. This includes the development and integration of solutions for Hospitalization at Home, enabling patients to receive complex, remotely supervised care using intelligent medical devices capable of sensing, analysing, and transmitting real-time data. This requires a continuum, from in-hospital diagnostics to robust, long-term patient support at home via AI-driven care pathways and hospitalization at home. • Prevention and treatment of diseases, allowing the improved…

Expected Outcome: Project results are expected to contribute to all the following expected outcomes: Advance in the achievement of the Strategic Energy Technology (SET) Plan’s research and innovation priorities and targets for wind energy; Efficient and effective support to wind energy research and innovation through alignment and cooperation among different actors, avoiding fragmentation of efforts; Energy producers and consumers benefit from increased performance of wind energy technologies with the focus on efficiency and flexibility, reduced cost, improved reliability and sustainability, operation and maintenance, safety, robustness and security during all stages of the lifetime of a wind energy farm from installation, operation and maintenance to decommissioning; Increased contribution of wind energy to the energy system, with minimal impacts on health and the environment (notably biodiversity and pollution) and at the lowest possible cost. Scope: The action contributes to address the Strategic Energy Technology (SET) Plan’s research and innovation priorities and targets for wind energy, as defined by the Implementation Working Group (IWG) on wind energy, the European…

Expected Outcome: this topic is a continuation of the co-funded European partnership for research into radiation protection and detection of ionising radiation (PIANOFORTE) and constitutes the EU’s contribution for 2026-2027. The establishment of the partnership will contribute to the expected outcomes specified in topic HORIZON-EURATOM-2021-NRT-01-09. The partnership is expected to contribute to all of the following outcomes: establishing improved risk estimates for the justification of practices and optimisation of radiological protection of members of the public, patients, workers and the environment in all exposure situations (medical, natural, occupational and accidental – including co‑exposure and overlapping risks) to support the implementation of the Basic Safety Standards Directive; advancing state-of-the-art understanding of the link between exposure characteristics (radiation quality, dose, dose-rate and dose effects versus gravity) and cancer and non-cancer effects (including optimised detection and dosimetry); developing a knowledge base and analytical tools for the major features of variability in radiation response (including tissue reactions, cancers and cellular…

Expected Outcome: This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to all the following expected outcomes: The EU is reinforced as an internationally recognised driver of research and innovation in Rare Diseases (RD) and thereby substantially contributing to the achievement of the Sustainable Development Goals related to rare diseases. Research funders align, adopt and implement their RD research policies allowing for the optimal generation and translation of knowledge into meaningful health products and interventions responding to the needs of people living with a rare disease across Europe and globally. The RD research community at large benefit from and use an improved comprehensive knowledge framework and cross-border FAIR [1] data access and analysis, including rare diseases registries, by integrating the EU, national/regional data and information infrastructures to improve translational research. People living with a rare…

Expected Outcome: Project results are expected to contribute to the following outcomes: For supported postdoctoral fellows Increased set of research and transferable skills and competences, leading to improved employability and career prospects of MSCA postdoctoral fellows within academia and beyond; New mind-sets and approaches to R&I work forged through international, inter-sectoral and interdisciplinary experience; Enhanced networking and communication capacities with scientific peers, as well as with the general public that will increase and broaden the research and innovation impact. For participating organisations Increased alignment of working conditions for researchers in accordance with the principles set out in the European Charter for Researchers; Enhanced quality and sustainability of research training and supervision; Increased global attractiveness, visibility and reputation of the participating organisation(s); Stronger R&I capacity and output among participating organisations; better transfer of knowledge; Regular feedback of research results into teaching and education at participating organisations. Scope: Fellowships will be provided to excellent researchers…

Specific Challenge: The “EU Award for Gender Equality Champions” is a recognition prize scheme designed as a booster and a complement to the Gender Equality Plans (GEP) eligibility criterion in Horizon Europe [1] , and as a tool for advancing inclusive GEPs and policies within the framework of the ERA Policy Agenda. Expected Outcomes : Recognition of organisations with the most significant impact resulting from the implementation of their GEP, serving as role models for others; Strengthened gender equality and inclusiveness in the European Research Area. The Prize will be awarded to four organisations, and contestants can apply to one of the following three prize categories: Sustainable Gender Equality Champions: Organisations that can demonstrate a significant and sustained record of activity and a high level of achievement through the implementation of their GEP(s); Newcomer Gender Equality Champions: Organisations without a sustained record of activity in gender equality that have recently completed the implementation of their first GEP and can demonstrate the most progress achieved through its implementation; Inclusive Gender Equality Champions: Organisations that have…

Specific Challenge: The “EU Award for Gender Equality Champions” is a recognition prize scheme designed as a booster and a complement to the Gender Equality Plans (GEP) eligibility criterion in Horizon Europe [1] , and as a tool for advancing inclusive GEPs and policies within the framework of the ERA Policy Agenda. Expected Outcomes : Recognition of organisations with the most significant impact resulting from the implementation of their GEP, serving as role models for others; Strengthened gender equality and inclusiveness in the European Research Area. The Prize will be awarded to four organisations, and contestants can apply to one of the following three prize categories: Sustainable Gender Equality Champions: Organisations that can demonstrate a significant and sustained record of activity and a high level of achievement through the implementation of their GEP(s); Newcomer Gender Equality Champions: Organisations without a sustained record of activity in gender equality that have recently completed the implementation of their first GEP and can demonstrate the most progress achieved through its implementation; Inclusive Gender Equality Champions: Organisations that have…

Specific Challenge: The “EU Award for Gender Equality Champions” is a recognition prize scheme designed as a booster and a complement to the Gender Equality Plans (GEP) eligibility criterion in Horizon Europe [1] , and as a tool for advancing inclusive GEPs and policies within the framework of the ERA Policy Agenda. Expected Outcomes : Recognition of organisations with the most significant impact resulting from the implementation of their GEP, serving as role models for others; Strengthened gender equality and inclusiveness in the European Research Area. The Prize will be awarded to four organisations, and contestants can apply to one of the following three prize categories: Sustainable Gender Equality Champions: Organisations that can demonstrate a significant and sustained record of activity and a high level of achievement through the implementation of their GEP(s); Newcomer Gender Equality Champions: Organisations without a sustained record of activity in gender equality that have recently completed the implementation of their first GEP and can demonstrate the most progress achieved through its implementation; Inclusive Gender Equality Champions: Organisations that have…