Alternatives to Decode the Immunoscience of age-related diseases

Expected Impact: The action under this topic is expected to achieve the following impacts: Faster and more informed decision-making through the use of an AI-driven NAM (AI Foundation Toxicology Model) and increased efficiency through rapid processing of vast amounts of data [1] . Increased consistency and standardisation in a NAM-based approach, specifically an AI model, used by industry in the efficient development, testing and production of safe and effective innovative health technologies, improving industrial competitiveness. Regulatory adoption of a NAM-enabled second species waiver model (AI Foundation Toxicology Model) and weight-of-evidence framework, in line with recommendations and more consistent global decision-making on waiving second species testing. Reduction in animal use, accelerated timelines and lower costs, enhancing the competitiveness of the European health industry through economical and ethical benefits. Improved public health as patients will benefit from safe and effective medicines developed faster using validated NAMs. The action is expected to contribute to the EU Directive (2010/63/EU) [2] on the protection of animals used for scientific purposes and…

Expected Impact: The action under this topic is expected to achieve the following impacts and contribute to the following EU policies/initiatives: deliver innovative, early technology solutions that contribute to addressing strategic unmet public health needs across multiple therapy areas to improve prevention, early diagnosis, and treatment; leverage the unique network and scale of IHI JU members to create a pipeline to support innovative startups in the health industry, fully integrated into European initiatives in support of start-ups and entrepreneurship; drive early cross-sector health R&D and innovation to strengthen the European healthcare industry’s global competitiveness, contributing to the EU Industrial Strategy and Pharmaceutical Strategy objectives; create a sustainable network of European healthcare incubators to guide and support highly talented and innovative early-stage companies; harness digital health and data-sharing technologies (e.g., AI and big data) to enable interoperable health solutions, contributing to the European Health Data Space (EHDS) and improved evidence based care;- the action should generate a portfolio of early‑stage companies that have…

Expected Outcome: Project results are expected to contribute to all the following expected outcomes: Advance in the achievement of the Strategic Energy Technology (SET) Plan’s research and innovation priorities and targets for wind energy; Efficient and effective support to wind energy research and innovation through alignment and cooperation among different actors, avoiding fragmentation of efforts; Energy producers and consumers benefit from increased performance of wind energy technologies with the focus on efficiency and flexibility, reduced cost, improved reliability and sustainability, operation and maintenance, safety, robustness and security during all stages of the lifetime of a wind energy farm from installation, operation and maintenance to decommissioning; Increased contribution of wind energy to the energy system, with minimal impacts on health and the environment (notably biodiversity and pollution) and at the lowest possible cost. Scope: The action contributes to address the Strategic Energy Technology (SET) Plan’s research and innovation priorities and targets for wind energy, as defined by the Implementation Working Group (IWG) on wind energy, the European…

Expected Outcome: Successful proposals will contribute to the implementation of the EU initiative on Biotechnology and Biomanufacturing and the EU Life Sciences Strategy as well as the updated EU Bioeconomy Strategy, the upcoming EU Biotechnology Act and EU Circular Economy Act. Projects’ results are expected to contribute to the following expected outcomes: Full industrial scale biorefinery and related value chain(s) for the production of nutritional food ingredients. Resilience and strategic autonomy of EU food sectors via diversification of nutritional food ingredient sources. Increased environmental sustainability of food sectors (e.g. addressing issues like land use, water use, energy consumption, nitrogen cycle, other nutrients, etc.). Improved consumers awareness and acceptance of nutritional food ingredients from alternative sources, contributing to sustainable healthy diets. Scope: Human nutrition is a key area where the bio-based industries can play an important role in addressing the present societal and climate challenges. Considerable attention is given to the utilisation of alternative sources of proteins, fibres and oils/fats, due to the increasing world population…

Expected Outcome: Project results are expected to contribute to all of the following expected outcomes: Increased evidence of factors such as physiological, behavioural, social, environmental and cultural that influence how different user and demographic groups perceive and use smart, secured, integrated energy efficient building systems, and how it affects the building whole-life cycle and energy savings, as well as occupant satisfaction, health and well-being; The design and operation of smart building systems and smart buildings are improved making them more user-friendly and effective. Scope: Significant investments have been made in developing hardware and software for smart buildings. There is still limited understanding how smart buildings solutions impact the energy performance of buildings and users’ comfort in practice. Research is required on the technical, social, and economic factors that influence how different groups – defined by their social, educational, age, and financial status – use and interact with smart buildings and systems. The whole-life cycle impacts of smart building have to be better understood, from design and construction to operation, maintenance,…

Expected Outcome: Project results are expected to contribute to all of the following expected outcomes: Implementation of the NWRSA methodology for secondary rural roads; Innovative and effective enforcement strategies, incentive mechanisms and measures raising risk awareness for fostering safer behaviour; Prevention strategies for reducing road fatalities and serious road traffic injuries on rural roads along with the respective implementation guidelines and policy measures tailored to the responsible stakeholders (regional authorities, police, healthcare professionals, national governments, etc.); GIS-based application to assist local and regional authorities in identifying and mapping the impact of extreme weather phenomena and other natural disasters (such as floods, fires, storms, heavy snowfall etc.) on the safety and resilience of the road network in their jurisdiction. Scope: With more than 50% of all EU road fatalities occurring in rural areas along with evidence suggesting that crashes and crash-related fatalities in rural roads vary from those in urban roads or motorways, it is imperative to understand and mitigate the safety risks in rural roads in view of the EU’s…

Expected Outcome: Project results are expected to contribute to all of the following expected outcomes: Better understanding of the factors and interdependencies that influence levels of renovation of rental properties in the affordable housing sector; Increased number of policy makers revise policies, regulations, instruments and business models to increase the rate of renovation of rental properties in the affordable housing sector. Scope: The Renovation Wave strategy sets out measures across the whole renovation chain that aim to increase the rate and depth of renovations. One of the key principles for housing renovation towards 2030 and 2050 is affordability, i.e. making energy efficient, comfortable, healthy, sustainable and climate-resilient buildings widely available, in particular for medium and lower-income households and vulnerable people and areas. A better understanding of the impact of current policy frameworks on the affordable housing sector and on energy poverty is needed. Proposals are expected to address all of the following: Research the effectiveness and implications of existing policies at different levels of governance (from local to European), regulations,…

Expected Outcome: Projects should contribute to either the first and second (combined), or the third and fourth (combined) of the following expected outcomes: Improved implementation of the EU Pact on Migration and Asylum through evidence-based insights in asylum and migration management, age assessment of minors, and resettlement frameworks, ensuring fair and efficient migration governance. Insight into legal pathways addressing both EU Member States’ needs and potential offers of circular and permanent migration schemes in selected partner countries. Enhanced health equity for migrants, including refugees by integrating robust health data into national systems, addressing governance barriers, and tackling intersectional inequities in healthcare access, identifying data/indicators on basic needs in health and sanitation, including as compared to adequate treatment. Comprehensive evaluation of long-term social inclusion and integration strategies, providing evidence-based policy recommendations for labour market access, housing, education, health (including mental health), recognition of qualifications and validation of skills, youth participation, and social, political, and…

Expected Outcome: Projects should contribute to all of the following expected outcomes: Reinforced digital transformation of the news media industry by facilitating the development of new business models, contributing to a more resilient and inclusive democracies. Citizens, particularly those facing systemic disadvantages, are empowered and better equipped to make informed decisions, and news media’s role as contributor to a healthy, reinvigorated and fair democracy is enhanced. Stronger engagement with emerging media creators (such as influencers and other online content producers) to promote transparency and accountability in their role in sharing information, and to foster reliance on trustworthy media sources. Scope: Democracies are at risk when reliable and independent journalism is at risk. Yet, in order to be truly independent, media need sustainable financing models. At present, journalistic newsrooms are under severe economic pressure. Social media forces them to compete for citizens’ attention with other forms of infotainment, which sometimes entail unverified opinions and low-quality or malicious sources. To promote a well-informed democratic debate, citizens must be…

Expected Outcome: Projects should contribute to all of the following expected outcomes: Evaluate the effectiveness and resilience of existing long term-care (LTC) policies at national and regional levels. Provide policy makers with scientific knowledge and data for evidence-informed policies to address the rising demand for affordable, accessible and high-quality long-term care, with the focus on efficient use of resources, including human, financial and technological. Propose new policy solutions to address rising long-term care needs and to ensure smooth (in)formal care transitions, including from the perspective of active and healthy ageing policies and the development of integrated care service provision at local level. Scope: In the EU, the number of people with long-term care needs is projected to increase in the future. In 2070, this number is expected to be 21% higher than in 2020.This increase is largely due to the acceleration of population ageing and also relates to higher needs for palliative care. At the same time, many Member States already struggle to meet all the long-term care needs now due to workforce shortages, which are likely to aggravate in future as the…

Expected Outcome: Projects should contribute to all of the following expected outcomes: Provide policymakers, education practitioners and citizens with a solid understanding of how social media, video gaming and other leisure uses of digital tools relate to the educational outcomes of young people, including through their impact on well-being and mental health. Generate rigorous, policy-relevant evidence about policies and practices aiming to inform and regulate young people’s use of digital tools for non-educational purposes, such as smartphones, at school. Develop actionable advice for policymakers and citizens about how to promote young people’s healthy use of digital tools for leisure, both at school and outside school. Describe and quantify the relationships of using digital tools for leisure and communication with students’ motivation, study habits, attention span and concentration, time management, engagement, social integration and overall well-being. Scope: The increasing prevalence of digital devices in young people’s life has raised concerns about the potential impacts of the use of digital tools for leisure and communication on primary-, secondary- and higher education…

Expected Outcome: Projects should contribute to all of the following expected outcomes: Policymakers, educators, and other relevant actors have tools and recommendations to put in place more opportunities for lifelong civic and citizenship [1] learning, in support of democracy and democratic participation, including by relying on the opportunities offered by digital means, notably civic tech. Policymakers at local, regional, national and EU level have tools and recommendations for ensuring the participation of citizens in democratic life, whatever their background, especially those who face barriers to participation in democratic processes. Scope: A healthy democracy relies on citizens being able to make informed democratic choices, in free and fair elections. Meaningful and inclusive citizens’ participation and engagement can further complement and reinforce representative democracies and foster trust in public institutions. Education plays a major role in supporting active interest in democratic participation and citizen engagement. Accessible education in matters of democracy and participation in public-policy making is a lifelong process that concerns all age groups in society…