Grants for Small business (Over $500K)

NSF-supported science and engineering research increasingly relies on cutting-edge infrastructure. With its Major Research Instrumentation (MRI) program and Major Multi-user Facilities ("Major Facilities") projects, NSF supports infrastructure projects at the lower and higher range of infrastructure project costs, Foundation-wide, across science and engineering research disciplines. The Foundation-wide Mid-scale Research Infrastructure opportunity is intended to provide NSF with an agile, Foundation-wide process to fund experimental research capabilities in the mid-scale range between MRI and Major Multi-user Facilities. NSF defines Research Infrastructure (RI) as any combination of facilities, equipment, instrumentation, or computational hardware or software, and the necessary human capital in support of the same. Major facilities and mid-scale projects are subsets of research infrastructure. The NSF Mid-scale Research Infrastructure-1 Program (Mid-scale RI-1) supports either design activities or implementation of unique and compelling RI projects. Mid-scale implementation projects may include any combination of equipment, instrumentation, cyberinfrastructure, broadly used large scale datasets and the personnel needed to successfully commission the project. Mid-scale RI-1 design activities include the design efforts intended to lead to eventual implementation of a mid-scale class RI project. Mid-scale RI-1 projects should involve the training of a diverse workforce engaged in the design and implementation of STEM research infrastructure. Mid-scale RI-1 projects should directly enable advances in any of the research domains supported by NSF. Projects may also include upgrades to existing research infrastructure. Mid-scale RI-1 emphasizes strong scientific merit, a response to an identified need of the research community and/or fulfillment of a national need to enable U.S. researchers to be competitive in a global research environment. Well-conceived technical and management plans are essential for both design and implementation proposals, as are well-developed plans (e.g., mentoring and professional development) for student training and the involvement of a diverse STEM workforce in all aspects of mid-scale design and/or implementation activities. The inclusion of individual project participants that will lead to a supportive working environment is especially encouraged at all levels of the project team. Within Mid-scale RI-1, proposers may submit two types of projects, “Implementation” (e.g., acquisition and/or construction) or “Design”. The “Design” track is intended to facilitate progress toward readiness for a mid-scale range implementation project. Both Implementation projects and Design activities may involve new or upgraded research infrastructure. Mid-scale RI-1 "Implementation" projects may have a total project cost ranging from $4 million up to but not including $20 million. Mid-scale RI-1 "Design" activities may request less than $4 million, with a minimum request of $400,000 and a maximum request up to but not including $20 million, as appropriate, to prepare for a future mid-scale range implementation project. Note: Successful award of a Mid-scale RI-1 design activity does not imply NSF's commitment to the future implementation of the project being designed, nor is a Mid-scale RI-1 design award required for the submission of an implementation project. The Mid-scale RI-1 Program seeks to broaden the representation of PIs and institutions in its award portfolio, including a geographically diverse set of institutions (especially those in EPSCoR jurisdictions). Proposals submitted by, or involving partnerships between institutions are encouraged. Participation in this opportunity is encouraged for the full spectrum of diverse talent society has to offer to include PIs who are women, early-career researchers, persons with disabilities, or members of other groups underrepresented in STEM. To improve participation in science and engineering research for persons with disabilities, Mid-scale RI-1 encourages PIs to incorporate accessibility as part of Mid-scale RI-1 design activity and implementation projects. Please consult NSF's Research Infrastructure Guide, or RIG (available at https://www.nsf.gov/bfa/lfo/lfo_documents.jsp ), for definitions of certain terms used in this solicitation, such as the Project Execution Plan (PEP) and Design and Execution Plan (DEP). The RIG provides guidance specific to Mid-scale Research Infrastructure Projects, including references to other parts of the RIG as needed. Note that PEP or DEP should be appropriately scaled for the complexity of the project and may not require all of the elements described in the RIG. Mid-scale research infrastructure projects with total project costs beyond the Mid-scale RI-1 Program limit are separately solicited through the Mid-scale RI-2 Program. Proposals to the Mid-scale RI-1 Program with total project costs outside of this solicitation's budgetary limits, either during initial submission or after cost analyses/revisions during subsequent review, are subject to return without further review.

FindBusinessSupport.gov.scot gives an overview of grants, loans, funding, advice and other support available to businesses in Scotland, offered by over 100 Scottish public sector organisations, conveniently in one place. Information is available for businesses of all sizes and sectors, from start-ups and sole traders to large enterprises and includes support for social enterprises.

The purpose of this Notice of Funding Opportunity (NOFO) is to leverage NICHD clinical research Network infrastructure relevant to infants, children, women, pregnant and lactating women, and persons with disabilities to conduct innovative, multisite, investigator-initiated clinical trials and observational studies. This NOFO will utilize a bi-phasic (UG3/UH3), milestone-driven mechanism consisting of a start-up phase (UG3) and a full enrollment and clinical trial implementation phase (UH3). Applications submitted in response to this NOFO must address specific aims and milestones for both the UG3 and UH3 phases. A UG3 project (phase I) that meets its milestones will be administratively considered by NICHD and prioritized for transition to the UH3 award (phase II). This NOFO provides an opportunity to leverage NICHD clinical research Network infrastructure as a platform for investigator-initiated innovative hypotheses by any investigator in the extramural community. Applications must be submitted as investigator-initiated, multi-Project Director/Principal Investigator (PD/PI) grant applications in conjunction with the respective NICHD-supported Network Data Coordinating Center (DCC), or equivalent as determined by the NICHD.

The purpose of this notice of funding opportunity (NOFO) is to support efficient and innovative natural history studies that advance medical product development in rare diseases/conditions with unmet needs. Through the support of natural history studies with high quality and interpretable data elements, FDA expects to address critical knowledge gaps, remove major barriers to progress in the field, exert a significant and broad impact on a specific rare disease or multiple rare diseases with similar pathophysiology, and facilitate rare disease product development.