Research grants & funding

Expected Outcome: The targeted outcomes reflect the above challenges and cover a comprehensive Front End module design which: Covers the FR3 range as defined by the relevant Agenda Item of WRC 27 (7 to 15 GHz range) with possible extension up to 24 GHz if required by some regional implementations, with inherent tuning capabilities to accommodate potential regional variations. Mitigates interferences with incumbent FR3 band users and maximises sharing capabilities across the band in line with the European regulatory approach on spectrum sharing. Enables integration of a large number of antenna elements beyond the State of the Art and support massive MIMO implementation with compensation of increased path loss compared to 5G FR1 implementations. Enables at least an order-of-magnitude increase in RF processing compared to 5G FR1 implementations. Enables 5G cell site reuse and minimises deployment complexity on top of 5G sites deployment. Enables low-cost and low energy implementation of the elementary constituent modules, efficient packaging and is mainly based on the integration of microelectronics heterogeneous technologies where European industry has strong expertise and…

Expected Outcome: Objectives and profile of the ERC Plus Grant Principal Investigator The ERC Plus Grant supports outstanding Principal Investigators who address a major scientific challenge. Applications for ERC Plus Grants should be for projects that could not be carried out with a regular ERC grant. Applicants should explain how the proposed project aims go beyond those of a regular ERC project, for example, because they have a vision to transform their field or open a new field of research. Scholars at all career stages can apply for an ERC Plus Grant if they have an outstanding record of scientific achievement at the forefront of their field. Their intellectual leadership will be evaluated in comparison to peers at their own career stage. It is expected that a researcher may be the Principal Investigator of only one ERC Plus Grant in their lifetime. Applicants should be aware that every year, only some 30 ERC Plus Grants can be awarded across all fields and all career stages, compared to approximately 1000 Starting, Consolidator and Advanced Grants. This level of competitiveness should be taken into account when considering whether to submit an application. Size of ERC Plus…

Expected Outcome: the proposals under this call are expected to address one or more of the following subjects : • Enhanced personalized monitoring, care and treatments, focusing on the development of highly customized healthcare solutions, including the required research and diagnostic tools, tailored to individual needs, covering various scenarios such as chronic disease management, physiotherapy, precision diagnosis, personalized medicine/treatment, pre- and postoperative care, and daily assistance in homes and common spaces. It also targets effective management of chronic diseases and elderly care through personalized monitoring and interventions facilitated by advanced sensor technologies and edge-to-cloud solutions. This includes the development and integration of solutions for Hospitalization at Home, enabling patients to receive complex, remotely supervised care using intelligent medical devices capable of sensing, analysing, and transmitting real-time data. This requires a continuum, from in-hospital diagnostics to robust, long-term patient support at home via AI-driven care pathways and hospitalization at home. • Prevention and treatment of diseases, allowing the improved…

Expected Outcome: The proposals under this topic should address the design/specification and implementation/testing of the key microelectronics building blocks of an FR3 FEM paving the way towards their future integration into a complete integrated FEM system. • Progresses the State of the art to optimise the cost-performance trade off to serve the target ITU IMT 2030 specifications, notably for what concerns maximum data rate, user data rate, spectral efficiency, whilst enabling 50% mobile transmission system energy consumption; • Allows operational implementation of spectrum sharing with other spectrum users within the selected FR3 sub-band; • Enables large arrays integration for increased path loss compensation at FR3 frequencies with very compact, low power, high efficiency FEM integration; • Enables high bandwidth for carrier aggregation with broadband RF transceivers; • Enables SBFD (Sub-Band non overlapping Full-Duplex) for UL coverage extension (Rel.-19 5G-Advanced in 3GPP) with appropriate interference cancellation techniques; • Enables ISAC (Integrated Sensing and Communications) supporting monostatic as well as bistatic radar functionality, and addressing interference…

Expected Outcome: The focus needs to be on areas where Digital Partnership countries bring strong complementary expertise, including advanced packaging, heterogeneous integration, and photonic chip technologies. The topic would aim to foster collaboration between European and Digital Partnership countries’ R&I communities. Projects are expected to contribute to the following outcomes: • Innovative design and integration concepts for neuromorphic computing systems supporting very low energy consumption, connectivity, embedded functions for mobile applications. • Alternative manufacturing process technologies for semiconductor chips including frontend or backend for heterogenous integration. The technologies should sustain in the mid- and long-term the fast-paced evolution of device performance, miniaturisation and cost, while reducing the environmental footprint. • Very advanced packaging solutions aiming heterogeneous integration of multiple functions and materials for applications in communication (RF, mmW or THz), sensing, actuating, power management and active/passive integration.

The opportunity for the Federal Aviation Administration (FAA) Center of Excellence for Alternative Jet Fuel and Environment (AJFE) was awarded in 2013 to the ASCENT cooperative aviation research organization. ASCENT is a coalition of 16 leading US research universities committed to improving the understanding of aviation noise and emissions and the modeling of aviation systems. ASCENT is co-led by Washington State University and the Massachusetts Institute of Technology (https://ascent.aero/). Any new grant opportunities under AJFE are open and available only to the university members of ASCENT.”

Expected Outcome: This action will establish a strategic European initiative to develop scalable, modular, and interoperable photonic quantum computing platforms. Proposals for this topic are expected to address and provide credible solutions to at least two major technical roadblocks currently limiting the advancement of photonic quantum computing such as: The lack of deterministic, high-efficiency photonic entanglement and loss-tolerant architectures suitable for fault-tolerant scaling The absence of a standardised, integrated control stack combining photonic hardware, firmware, and system software with reliable benchmarking across platforms Project results are expected to contribute to the following expected outcomes: By 2028, demonstration of a photonic NISQ processor with ≥100 photonic qubits, integrating deterministic single-photon sources, low-loss waveguides, on-chip detectors, and a firmware stack (scheduler, controller, compiler), validated via hardware-agnostic benchmarks and hybrid photonic-HPC applications demonstrating classical-quantum crossover By 2030, delivery of a full-stack, high-connectivity photonic quantum computer, with modular scalability, integrated…

Expected Outcome: Practical chip design experience integrated into education at multiple levels; at least 1,000 students across Europe completing funded tape-outs over 4 years; stronger reskilling pathways for students from adjacent fields; and a sustainable, continent-wide pipeline of chip design talent to support Europe's semiconductor ambitions. Scope: This call funds a comprehensive Chip Design Skills Programme to lower barriers to entry in chip design and tape-outs. At least 60% of the budget must support hands-on tape-out experiences (via multi-project wafers) for university and secondary school students.

Expected Outcome: Expected outcomes: A sustained pipeline of highly qualified semiconductor graduates, with shorter time-to-readiness for industry roles; greater inflow of diverse talent including women and underrepresented groups; improved intra- and extra-EU student mobility; and strong complementarity with existing Chips Act infrastructure such as pilot lines, design platforms, and Competence Centres. Scope: This call funds the creation of specialised academic "Hubs of Excellence" in critical semiconductor technology areas (e.g. chip design, manufacturing, photonics, power electronics). Projects should build industry-aligned Bachelor, Master, and PhD programmes.

Expected Impact: The action under this topic is expected to achieve the following impacts: Faster and more informed decision-making through the use of an AI-driven NAM (AI Foundation Toxicology Model) and increased efficiency through rapid processing of vast amounts of data [1] . Increased consistency and standardisation in a NAM-based approach, specifically an AI model, used by industry in the efficient development, testing and production of safe and effective innovative health technologies, improving industrial competitiveness. Regulatory adoption of a NAM-enabled second species waiver model (AI Foundation Toxicology Model) and weight-of-evidence framework, in line with recommendations and more consistent global decision-making on waiving second species testing. Reduction in animal use, accelerated timelines and lower costs, enhancing the competitiveness of the European health industry through economical and ethical benefits. Improved public health as patients will benefit from safe and effective medicines developed faster using validated NAMs. The action is expected to contribute to the EU Directive (2010/63/EU) [2] on the protection of animals used for scientific purposes and…

Expected Outcome: Projects should contribute to all the following expected outcomes: Enhanced understanding, accompanied by documented good practices, showing what works to encourage multilingualism in society and what type of practices have led to safeguarding linguistic heritage, including lesser used, endangered and historically marginalised languages. Rigorous policy-relevant evidence, strategies and policy recommendations for promoting multilingualism and safeguarding linguistic diversity are available to policy makers, and users are involved in their development, especially the younger generation. Non-linguistic benefits of language maintenance and revitalisation are well documented, communicated and understood by different stakeholders. Citizens are empowered and engaged in the sustainable management of their own linguistic heritage and resources, with a focus on intergenerational dialogue and education activities, with particular attention to communities where oral transmission is the primary mode of language preservation. Maps and visual presentations showing the linguistic diversity in Europe are available, including a variety of existing languages (regional and minority…

Expected Impact: The action under this topic is expected to achieve the following impacts: Accelerate EU access to more cost-effective interventions in an increasingly ageing population by identifying personalised treatment approaches for elderly-onset immune diseases. Decrease disease risk later in life by defining specific prevention strategies based on ageing biomarkers and risk factors. Halt age-associated disease exacerbation by the identification of predictive and digital biomarkers that can stratify patients for early intervention. Improve quality of life for healthy individuals and patients by preventing further health decline, avoiding escalating care costs, and properly stratifying individuals earlier in the diagnostic pathway. Accelerate adoption of innovative diagnostic, preventative, and therapeutic strategies, strengthening the EU’s position as a healthcare innovator. Evaluate digital biomarker as potential regulatory endpoints in the ultimate goal to develop medicines for ‘healthy ageing’. Integrate fragmented research efforts by bringing together health industry sectors and stakeholders to develop clinical and multi-omics data integration capabilities. Enable new…

Expected Outcome: Proposals should contribute to the first two expected outcomes, and either the one listed under Focus 1, or the one listed under Focus 2. The potential of art-science and/or technology collaborations to address societal challenges and drive innovation is better understood. Guidance, toolkits, and actionable methodologies are developed to promote these collaborations, providing policymakers, professionals, and training organisations with clarity on intervention scope, applicability across various fields, and evaluation methods, metrics, or tools. New and existing national, European or international networks for art-science-technology collaborations are established or strengthened, expanding opportunities for artists to engage with science and technology. Focus 1 Approaches, methodologies and model interventions for integrating arts and creative practices to enhance soft skills across public and private sectors are developed, tested and disseminated. Focus 2 The effectiveness of critical artists’ engagement in interdisciplinary teams is demonstrated alongside the assessment of the viability of research-intensive emerging technologies through at least three low…

Expected Impact: The action under this topic is expected to achieve the following impacts and contribute to the following EU policies/initiatives: deliver innovative, early technology solutions that contribute to addressing strategic unmet public health needs across multiple therapy areas to improve prevention, early diagnosis, and treatment; leverage the unique network and scale of IHI JU members to create a pipeline to support innovative startups in the health industry, fully integrated into European initiatives in support of start-ups and entrepreneurship; drive early cross-sector health R&D and innovation to strengthen the European healthcare industry’s global competitiveness, contributing to the EU Industrial Strategy and Pharmaceutical Strategy objectives; create a sustainable network of European healthcare incubators to guide and support highly talented and innovative early-stage companies; harness digital health and data-sharing technologies (e.g., AI and big data) to enable interoperable health solutions, contributing to the European Health Data Space (EHDS) and improved evidence based care;- the action should generate a portfolio of early‑stage companies that have…

Expected Outcome: Projects should contribute to all of the following expected outcomes: EU national and local policymakers develop and implement effective strategies for sustainable peace and democratic reconstruction in post-conflict areas, promoting stability, inclusivity, equity, security, human rights, and strengthening integrity and anticorruption measures to ensure transparent, accountable, and ethical use of reconstruction aid. EU and national policymakers inform their decision-making with evidence-based recommendations on international cooperation, EU democracy support, and civil society engagement in post-conflict reconstruction, leading to more effective, inclusive and sustainable reconstruction efforts. Local civil society organisations and community groups, with a focus on persons and groups in a vulnerable situation in post-conflict countries, provide guidance and support to educators, media professionals, public administrators, and other stakeholders on promoting reconciliation, accountability, and sustainable peace. Specialised service providers, including NGOs and community organisations, offer support services and programmes to veterans and the persons and groups…

Expected Outcome: Projects should contribute to all of the following expected outcomes: Policymakers, educators, and other relevant actors have tools and recommendations to put in place more opportunities for lifelong civic and citizenship [1] learning, in support of democracy and democratic participation, including by relying on the opportunities offered by digital means, notably civic tech. Policymakers at local, regional, national and EU level have tools and recommendations for ensuring the participation of citizens in democratic life, whatever their background, especially those who face barriers to participation in democratic processes. Scope: A healthy democracy relies on citizens being able to make informed democratic choices, in free and fair elections. Meaningful and inclusive citizens’ participation and engagement can further complement and reinforce representative democracies and foster trust in public institutions. Education plays a major role in supporting active interest in democratic participation and citizen engagement. Accessible education in matters of democracy and participation in public-policy making is a lifelong process that concerns all age groups in society…

Expected Outcome: Projects should contribute to all of the following expected outcomes: Deepened understanding and comprehensive evaluation of cultural policy models, creative industry ecosystems, and strategies for promoting creative industries across world regions, identifying good practices, success stories and replicable models. Innovative practices, policy approaches, shared challenges, and opportunities for cross-regional collaboration and global development of creative industries are identified. International equal partnerships and collaborations are established to exchange cultural policy approaches, boost creative industries, and/or support collaborative production or co-creation, facilitating knowledge transfer and capacity building among participating actors. Actionable strategies are available to policymakers, businesses, and stakeholders, for cross-regional collaborations that strengthen cultural ties, leverage creative industries, culture, and the arts as central to Global Europe, and support global culture- and creativity-driven innovation and resilience. Scope: This topic explores how international partnerships can strengthen cultural policies and creative…

Expected Outcome: Projects should contribute to all of the following expected outcomes. Country government innovation info sheets, trends, inspiring good practices, the most innovative solutions recently developed or work in progress for next-generation governance and future-informed public decision making in EU Member States and Associated Countries (MS/AC). Policy recommendations for both EU level and MS/AC level actions on adopting new governance paradigms, and strategies for enhanced (technical and financial) support for internal government innovation efforts. Publication of lessons learned to enlighten government officials and the public about the often-invisible internal innovation strategies and impactful solutions in national governments. A comprehensive MOOC (Massive Online Open Course) for government officials with relevant examples and cases. Fostering of closer ties and collaboration among MS/AC (and any other relevant actors) to leverage national capabilities in innovative governance and maintain peer learning through e.g. relevant networks and knowledge exchange platforms. Scope: In an era characterized by numerous concurrent crises, accelerated technological…

Expected Outcome: Projects should contribute to all of the following expected outcomes: EU institutions and national decision-makers, have a better understanding of how to foster democratic resilience through media and digital literacy, equipping societies to adapt and thrive in the face of evolving technological, political, and societal challenges. Citizens are empowered to navigate the digital landscape with discernment and critical thinking, actively engaging with media and other source of information, ensuring informed democratic participation. Scope: As recalled by the “Safer together” report [1] , “over the past years, the Commission has already taken steps to counter hybrid threats (including foreign information manipulation and interference/FIMI) and enhance democratic resilience across the EU. It adopted, among other initiatives, the European Democracy Action Plan [2] to build more resilient democracies across the EU by promoting free and fair elections, strengthening media freedom, countering disinformation and FIMI and promoting information integrity. With the adoption of the Digital Services Act [3] (DSA) and its binding obligations for online platforms to combat the…

Expected Outcome: Projects should contribute to all of the following expected outcomes: Provide policymakers, education practitioners and citizens with a solid understanding of how social media, video gaming and other leisure uses of digital tools relate to the educational outcomes of young people, including through their impact on well-being and mental health. Generate rigorous, policy-relevant evidence about policies and practices aiming to inform and regulate young people’s use of digital tools for non-educational purposes, such as smartphones, at school. Develop actionable advice for policymakers and citizens about how to promote young people’s healthy use of digital tools for leisure, both at school and outside school. Describe and quantify the relationships of using digital tools for leisure and communication with students’ motivation, study habits, attention span and concentration, time management, engagement, social integration and overall well-being. Scope: The increasing prevalence of digital devices in young people’s life has raised concerns about the potential impacts of the use of digital tools for leisure and communication on primary-, secondary- and higher education…

Expected Outcome: Projects should contribute to all of the following expected outcomes: Provide policymakers, education and training institutions, and social partners with a solid understanding of which competences young people and workers need to support the EU economy towards the green transition to reach carbon neutrality and protect natural ecosystems. Develop actionable advice to policymakers and education and training institutions about which education and training programmes and policy measures can promote the acquisition of those competences by young people and workers in a lifelong perspective, including the gender and disability dimensions. Provide policymakers with guidance on how to address the interconnection between fostering the competences for the green transition and those for the digital transition. Scope: Environmental challenges have been one of the key drivers of labour demand and skills supply across all sectors for the past years. More data and analysis from research on competences that young people and workers need for the green transition are warranted to properly implement the Union of Skills and support people in upskilling and reskilling. The…

Expected Outcome: Projects should contribute to all of the following expected outcomes: EU institutions and national decision-makers are equipped with science-based tools, toolkits, training models, monitoring frameworks, and recommendations to proactively promote inequality reduction, human rights and democracy, in order to lead to more resilient and inclusive democratic societies in low-income and low-middle income countries [1] EU institutions and national decision-makers are better able to proactively promote democratic values, principles and practices in low- and low-middle income countries grounded in a better understanding of the actors at local level including their capacity and needs when engaging in democratic practices. EU institutions, national decision-makers, and civil society organisations can access and use (evidence-based) good practices for working in fragile contexts [2] EU institutions and national decision-makers understand the role of decentralization processes in low-income and low-middle income countries, and its impact on the quality of public services and on acceptance of democratic processes among citizens. In addition, projects should contribute to at…

Expected Outcome: Projects should contribute to all of the following expected outcomes: Greater integration of SSH and STEM [1] research and innovation in R&I initiatives funded at EU level, national and/or regional level, as well as in R&I policies by promoting dialogue, mutual learning and strategic cooperation among research funders and policy makers in the EU. Developing and maintaining a new, common, comprehensive ‘Monitoring and Impact Evaluation Framework’ for SSH integration in current and future EU R&I initiatives. Enhanced facilitation of knowledge exploitation and support to the cooperation between projects and stakeholders, as well as R&I policies involved in projects and other types of cross-border networks dealing with SSH and STEM research and innovation. Scope: As mentioned in the Report ‘Align, Act, Accelerate: Research, Technology and Innovation to boost European Competitiveness’ [2] , European RD&I can provide a new understanding of and solutions to tackle societal challenges. Social sciences and humanities (SSH) and Science, Technology, Engineering and Maths (STEM) improve the research activities, outcomes and impacts of Horizon Europe, because they enable a…

Expected Outcome: Project should contribute to all of the following expected outcomes: Research funders, policymakers and research communities in the social sciences and humanities (SSH) are provided with a multi-annual R&I programme on social transformations and resilience, responding to megatrends like climate change and biodiversity loss, digitalisation, demographic changes and unexpected shocks. Research investments on social protection and essential services, future of work, education and skills, and a fair transition to climate neutrality are increased. Stakeholders, including social partners and civil society, and policymakers are provided with evidence-based knowledge, tools and innovative solutions, which contribute to new policies and strategies for strengthening resilience, fairness, inclusiveness and social cohesion at European, national and regional level. Scope: Europe is undergoing critical social transformations driven by macro drivers of change, such as climate change, biodiversity loss, digitalisation and demographic change, which have been accelerated by events, such as the COVID-19 pandemic and Russia’s war of aggression against Ukraine. These transformations…

Expected Outcome: Projects should contribute to all of the following expected outcomes: Policymakers gain insights into the cost of child poverty and the returns from securing access of disadvantaged children to quality Early Childhood Education and Care (ECEC) in the EU. Policymakers receive operational advice on ways to reduce this cost and support participation of disadvantaged children in quality ECEC to close the gap with other children in the EU. Scope: Past studies researched the cost of child poverty, and the returns yielded by and ways to secure disadvantaged children’s participation to ECEC, yet their relevance to the current EU context is limited (i.e. most of them were conducted outside of the EU or they are now outdated). Producing EU-specific insights on these issues is the aim of this topic, which should help close the ECEC participation gap and improve social outcomes, in line with the European Pillar of Social Rights, while fostering fiscal sustainability and inclusive growth. The proposals may: Define disadvantaged children, by going beyond monetary aspects of disadvantages, building on the EU’s concept of risk of poverty or social exclusion, and taking into…

Expected Outcome: Projects should contribute to all of the following expected outcomes: The concept of sustainable competitiveness is analysed taking into account the shifts in geopolitics, global trade patterns, as well as changes in climate, the environment (including biodiversity loss [1] ), technology and demography. Policymakers are provided with recommendations and innovative solutions, including a toolbox to boost Member States and Associated Countries (labour) productivity while ensuring high social and environmental standards and increasing competitiveness within planetary boundaries. Scope: The Future of European competitiveness report (also known as the Draghi report) [2] analysed and discussed the reason for European declining competitiveness, productivity and growth vis-a-vis its main competitors. A competitive economy is defined as an economy whose sustained rate of productivity is able to drive growth and, consequently, income and welfare. Both the economy and the European social model have to adapt to the great drivers of change, including demography, technology, global trade patterns, climate, and geopolitical shifts. From its side, the European social model is…

Expected Outcome: Project results are expected to contribute to all the following expected outcomes: Availability and integration of advanced, trustworthy, energy-efficient perception systems, exploiting technological advancements of Generative AI (GenAI) to enhance situational awareness and support safe decision-making; Enhanced Vulnerable Road User (VRU) safety, based on elevated, more temper-proof perception and understanding of their behaviour and intention predictions; Enhanced robustness of CCAM systems - both on-board and on the infrastructure side - in critical situations due to their training, virtual testing and validation in scenarios generated by GenAI, complementing existing scenario databases for the testing and validation of CCAM systems; Enhanced understanding of the relevance and limitations of using GenAI for CCAM; Tools and harmonised approaches for the use of GenAI in mobility technology development, training and validation, as well as for systemic applications such as traffic management and remote control, integrating them into existing approaches. Scope: Pilots and demonstrations using Level 3 and 4 vehicle services face major challenges in perception and…

Expected Outcome: Projects should contribute to all of the following expected outcomes: EU and national policymakers and relevant stakeholders get an enhanced understanding of the drivers of violence against women and LGBTIQ people who are politically active or political aspirants. Enhanced prevention and early intervention through better understanding of the drivers and impacts of violence (short- and long-term) on women and LGBTIQ people engaged, or aspiring to engage, in online and offline political activities and how their participation evolves after experiencing violence and harassment. Uptake of evidence-based policy recommendations by policymakers and relevant stakeholders on tackling gender-based violence alongside violence against politically active women and LGBTIQ people, promoting equal political participation and addressing harmful narratives. Broader adherence to media guidelines on responsible, ethical, and safe portrayals of and reporting on gender-based violence in a political context, embedding gender-sensitive and intersectional reporting and incorporating successful practices with demonstrable, positive outcomes. Promotion of an inclusive environment that…

Expected Outcome: Projects should contribute to all of the following expected outcomes: Policymakers are made aware and are equipped with the knowledge and tools to integrate inclusive and intersectional perspectives into their policymaking, which strengthens their capacity to promote and protect democracy, fundamental rights, and EU values. Researchers gain insights on how to translate their findings on intersectional inequalities and democracy into actionable, evidence-based recommendations, enabling them to effectively inform policy and practice at local, regional, national, and EU levels. Innovative solutions developed under Horizon Europe and other EU-funding programmes empower equally all citizens, to participate in democratic processes and decision-making. Scope: This call topic aims to establish a Research and Innovation Network for a Union of Equality. The proposed network should bring together academic institutions, public bodies and civil society organisations to collaborate and promote the advancement of inclusive, equal, and resilient democratic societies. The proposed network should contribute to the development of a comprehensive approach to democracy, fostering a…

Expected Outcome: Projects should contribute to all of the following expected outcomes: Provide policymakers with a more detailed understanding of the contribution of basic skills on the economy in the short and medium term, with a focus on their contribution to productivity and innovation, to sustain EU competitiveness and growth. Develop actionable advice about how, in a lifelong perspective, education and training systems can help foster basic skills. Promote productivity, innovation, competitiveness and growth, including by reducing gender, disability and socioeconomic gaps in basic skills. Scope: In the context of the Union of Skills, the 2025 European Commission’s Action Plan on Basic Skills identifies five basic skills: literacy, mathematics (including also financial literacy), science, digital and citizenship. Strong basic skill levels among young people and adults are key to sustaining EU productivity, innovation, competitiveness and growth, as also explained in the 2024 Draghi Report [1] . Other key EU initiatives support lifelong learning as a driver for productivity, innovation, and economic growth, for instance the 2022 Council Recommendation encouraging the…

Expected Outcome: Project results are expected to contribute to all the following expected outcomes: Advance in the achievement of the Strategic Energy Technology (SET) Plan’s research and innovation priorities and targets for wind energy; Efficient and effective support to wind energy research and innovation through alignment and cooperation among different actors, avoiding fragmentation of efforts; Energy producers and consumers benefit from increased performance of wind energy technologies with the focus on efficiency and flexibility, reduced cost, improved reliability and sustainability, operation and maintenance, safety, robustness and security during all stages of the lifetime of a wind energy farm from installation, operation and maintenance to decommissioning; Increased contribution of wind energy to the energy system, with minimal impacts on health and the environment (notably biodiversity and pollution) and at the lowest possible cost. Scope: The action contributes to address the Strategic Energy Technology (SET) Plan’s research and innovation priorities and targets for wind energy, as defined by the Implementation Working Group (IWG) on wind energy, the European…

Expected Outcome: Battery recycling is of strategic importance for both Europe and India, not only to keep raw materials in the respective territories but also to reduce the environmental impact of the recycling process. R&I in this area has been identified as a priority by the EU-India Trade and Technology Council’s Working Group on Green and Clean Energy Technology to reinforce bilateral cooperation. Project results are expected to contribute to all of the following expected outcomes: Battery recyclers based in the EU and India benefit from of the improved sustainability, safety, and affordability of innovative recycling processes. Stakeholders on battery recycling based in the EU and India benefit from each other’s experience on recycling logistics, including the informal processes and supply chain constraints. The cooperation between EU and India key researchers, institutions and industries which are active in battery recycling is supported and strengthened. Scope: Projects are expected to build a jointly operated recycling pilot line on Indian soil demonstrating innovative recycling processes for lithium-ion batteries going beyond the current state of the art in terms of…

Expected Outcome: Projects should contribute to all of the following expected outcomes: Generate rigorous, policy-relevant evidence on the factors that may influence students, researchers, and high-skilled workers from non-EU countries to move to and remain in the EU. Provide policymakers and higher education/research institutions with guidance on which policies and programmes could be effective in attracting talented students, researchers and high-skilled workers from non-EU countries to the EU. Develop actionable advice to policymakers and higher education/research institutions about how to retain talented students, researchers and high-skilled workers from non-EU countries to ensure a long-term positive impact on the EU economy’s innovation and competitiveness. Provide evidence-based policy insights/options to improve the coherence of migration pathways for skilled talent across the EU. Support the development of more flexible and attractive mobility schemes, reducing administrative barriers, increasing accessibility and enhancing retention mechanisms to enhance the EU’s competitiveness in research, innovation, and cultural exchange. Scope: The EU’s ability to compete on a…

Expected Outcome: Proposals are expected to contribute to all following points: Significantly reduced EU dependency on imported battery-grade raw materials, specifically emerging technologies and carbon-based electrode materials. Established European value chains for next-generation battery materials, enhancing the EU's technological leadership and strategic autonomy. Scope: Proposals under this topic are expected to address all aspects for one of the following categories: 1. Sustainable Processing and Refining of next generation batteries-grade Material, delivering all of the following: Development and validation of innovative, environmentally friendly refining technologies for producing battery-grade metals and materials suitable for next-generation battery chemistries. This covers raw and advanced electrode materials for the components of sodium-ion batteries or beyond generation 3 [1] lithium-ion batteries Development of processes achieving significant reductions in carbon and ecological footprint, emissions of pollutants, energy usage, and chemical inputs. The selected processes should not negatively impact any of the aspects above or cause significant harm. Validation of…

Expected Outcome: Proposals are expected to contribute to the following outcomes: Steer a European agenda to catalyse the development of a full software defined and hardware-enabled vehicle AD stack “built in Europe”, from onboard-compute architecture up to software in-vehicle up to the cloud. Establish structured intersectoral linkages between software, AI/data, hardware and deployment actors, ensuring that architectural decisions in the European AD stack are aligned across computing platforms, AI models, validation frameworks and real-world deployment environments. Promote a European R&I roadmap establishing pathways for the accelerated development of a European AI-powered AD stack, notably in close liaison with the relevant ECAVA Working Groups and relevant OSS initiatives. Ensure the engagement of key stakeholders across the Automotive value chain (including relevant OSS initiatives) toward an open-source software autonomous driving stack, including required industrial partners (such as OEMs, suppliers, tool-providers), and innovative R&I stakeholders (RTOs, universities, start-ups. If useful, already existing OSS AD stack initiatives together with the reference stacks (as…

Expected Outcome: Project results are expected to contribute to all the following expected outcomes: Assessment of Europe’s CCAM position in global competition, identifying strategic vulnerabilities, dependencies and opportunities across business models, supply chains, critical components, technological capabilities, infrastructure, and regulatory frameworks, supported by advanced AI-driven analytics and innovation mapping tools. Stakeholder-driven, participatory future scenarios and strategic pathways that define Europe’s leading role in the evolving geopolitical, technological, and economic landscape of CCAM. These should be developed using advanced foresight methods ( e.g. qualitative scenarios, horizon scanning, technology roadmapping, etc.), complemented by iterative validation through a minimum of 3 dedicated Living Labs selected to represent diverse European regions, urbanisation levels, and governance capacities, ensuring a structured, robust, and anticipatory approach to long-term decision-making. A data-driven understanding of the socioeconomic effects of different CCAM deployment pathways, based on a quantified assessment across Member States and Associated Countries,…

Expected Outcome: Successful proposals will contribute to the implementation of the EU initiative on Biotechnology and Biomanufacturing and the EU Life Sciences Strategy as well as the updated EU Bioeconomy Strategy, the Clean Industrial Deal, the European Chemical Industry Action Plan, the upcoming EU Biotechnology and Circular Economy Acts. Projects results are expected to contribute to the following expected outcomes: Increased added value of residual biomass for biorefinery applications. Availability of a wider portfolio of sustainable bio-based products via industrial biotech. Robust, scalable and efficient biotech process(es) applicable to residual biomass. Scope: Diversifying biomass feedstock resources for bio-based products is key to contribute to resilience and strategic autonomy of bio-based operations. Industrial biotechnologies have showcased that they can play a key role to address residual biomass into valuable bio-based products. However, scaling up from research to demo scale requires addressing systemic and technical challenges. This entails the integration of adequate pretreatment and conversion processes, tailored to the targeted residual biomass and its…

Expected Outcome: Project results are expected to contribute to all of the following expected outcomes: Increased evidence of factors such as physiological, behavioural, social, environmental and cultural that influence how different user and demographic groups perceive and use smart, secured, integrated energy efficient building systems, and how it affects the building whole-life cycle and energy savings, as well as occupant satisfaction, health and well-being; The design and operation of smart building systems and smart buildings are improved making them more user-friendly and effective. Scope: Significant investments have been made in developing hardware and software for smart buildings. There is still limited understanding how smart buildings solutions impact the energy performance of buildings and users’ comfort in practice. Research is required on the technical, social, and economic factors that influence how different groups – defined by their social, educational, age, and financial status – use and interact with smart buildings and systems. The whole-life cycle impacts of smart building have to be better understood, from design and construction to operation, maintenance,…

Treasury is publishing multiple funding opportunity notices for its RESTORE Act grant programs. This announcement applies only to the Centers of Excellence Research Grants Program.Trust Fund amounts are available to establish one or more Centers of Excellence through competitive subawards to nongovernmental entities and consortia in the Gulf Coast Region, including institutions of higher education. Funds may be used to establish Centers of Excellence, and by those Centers of Excellence for science, technology, and monitoring in one or more of the following disciplines as described in the RESTORE Act and Treasury’s implementing regulations at 31 CFR 34.704: 1) Coastal and deltaic sustainability, restoration, and protection, including solutions and technology that allow citizens to live in a safe and sustainable manner in a coastal delta in the Gulf Coast Region. 2) Coastal fisheries and wildlife ecosystem research and monitoring in the Gulf Coast Region. 3) Offshore energy development, including research and technology to improve the sustainable and safe development of energy resources in the Gulf of Mexico. 4) Sustainable and resilient growth, economic and commercial development in the Gulf Coast Region. 5) Comprehensive observation, monitoring, and mapping of the Gulf of Mexico.Eligible applicants issuing subawards to Center(s) of Excellence must establish and implement a program to monitor compliance with its subaward agreements.

Expected Outcome: Project results are expected to contribute to all of the following expected outcomes: Better understanding of the factors and interdependencies that influence levels of renovation of rental properties in the affordable housing sector; Increased number of policy makers revise policies, regulations, instruments and business models to increase the rate of renovation of rental properties in the affordable housing sector. Scope: The Renovation Wave strategy sets out measures across the whole renovation chain that aim to increase the rate and depth of renovations. One of the key principles for housing renovation towards 2030 and 2050 is affordability, i.e. making energy efficient, comfortable, healthy, sustainable and climate-resilient buildings widely available, in particular for medium and lower-income households and vulnerable people and areas. A better understanding of the impact of current policy frameworks on the affordable housing sector and on energy poverty is needed. Proposals are expected to address all of the following: Research the effectiveness and implications of existing policies at different levels of governance (from local to European), regulations,…

Expected Outcome: Projects should contribute to all of the following expected outcomes: EU institutions, Member States and decision-makers worldwide, relevant international organisations, civil society organisations and other societal actors have a better shared understanding of the systemic challenges and the underlying drivers and motivations that undermine managing global commons sustainably. EU institutions, Member States and decision-makers worldwide, relevant international organisations, as well as academies of science, higher education institutions and research-performing organisations are better equipped with the tools needed to improve the science-policy interface in the area of foreign and security policies in general, and multilateral / national science advisory bodies in the field of foreign policy in particular with a recognition of the need to engage citizens in a more participatory and inclusive approach to research and policy-making. Rules-based multilateralism is strengthened by the development of concepts, methods, processes, and information relevant for decision-making that foster the sustainable governance of global commons within the evolving geopolitical…

Expected Outcome: Projects should contribute to all of the following expected outcomes: Evaluate the effectiveness and resilience of existing long term-care (LTC) policies at national and regional levels. Provide policy makers with scientific knowledge and data for evidence-informed policies to address the rising demand for affordable, accessible and high-quality long-term care, with the focus on efficient use of resources, including human, financial and technological. Propose new policy solutions to address rising long-term care needs and to ensure smooth (in)formal care transitions, including from the perspective of active and healthy ageing policies and the development of integrated care service provision at local level. Scope: In the EU, the number of people with long-term care needs is projected to increase in the future. In 2070, this number is expected to be 21% higher than in 2020.This increase is largely due to the acceleration of population ageing and also relates to higher needs for palliative care. At the same time, many Member States already struggle to meet all the long-term care needs now due to workforce shortages, which are likely to aggravate in future as the…

Expected Outcome: Project results are expected to contribute to the following outcomes: Increased commercialisation of academic research results, by facilitating access for industry, startups and scaleups to the intellectual assets of academic research; Strengthened collaboration between industry and academia, reflected in an increased number of technology transfer deals and joint R&D projects resulting in market-ready innovations; Introduced more startup friendly intellectual asset transfer/licensing policies in universities/research and higher education institutions/RTOs; Increased number of spinoffs by enabling researchers to overcome the barriers to commercialising their intellectual assets; Reduced transaction costs related to Intellectual Property Rights (IPR) negotiations by establishing more standardised asset transfer policies across universities/research and higher education institutions/RTOs; Optimised transfer/licensing processes by universities/research and higher education institutions/RTOs based on grouping intellectual assets in portfolios that can be commercialised in package deals that are more attractive for industry and investors. Scope: Academic knowledge…

Expected Outcome: Projects should contribute to all of the following expected outcomes: An in-depth analysis of the socio-economic dimensions and impacts of generative AI on the cultural and creative sectors and related societal implications. Particular attention should be paid to rights and remuneration of creators, diversity of cultural expression, audience perception, consumption patterns, market dynamics, value chains, royalty allocation and the effectiveness of copyright infrastructure. Scenarios, value chains, standards and robust, agile solutions to ensure transparency and trust in the generative AI supply chain are developed, aiming for a fair and transparent market for cultural and creative content. This includes: systems for content provenance detection of AI-generated and manipulated creative content; tools and infrastructure that reinforce rights management, creators’ consent, control, and fair compensation for the use of their works in AI training and generation; measures supporting the findability and discoverability of trustworthy cultural and creative content; mechanisms for the long-term preservation and stewardship of AI-generated creative works. Adaptive policy…

Expected Outcome: Projects should contribute to all of the following expected outcomes: EU, national and local policymakers possess the necessary knowledge to inform the development of election regulations, standards and tools that address the use of digital technologies in elections and political campaigns, ensuring their integrity, inclusiveness, accessibility, fairness, transparency, and security. Organisations involved in electoral processes develop and implement guidelines for the responsible use of digital technologies in elections and political campaigns, aligned with EU and national regulations. Enhanced transparency and accountability in AI-powered political campaigns, achieved through requirements for AI system audits, data disclosure, transparency regarding algorithms and sources of Large Language Models (LLMs), and responsible AI development. Scope: The integrity of electoral processes in Europe is facing challenges in the digital age. The digital transformation of democratic processes has created new avenues for citizen engagement, but it also poses significant risks from disinformation to the integrity of electoral and other democratic processes. Concerns about…

Expected Outcome: Projects should contribute to either the first and second (combined), or the third and fourth (combined) of the following expected outcomes: Improved implementation of the EU Pact on Migration and Asylum through evidence-based insights in asylum and migration management, age assessment of minors, and resettlement frameworks, ensuring fair and efficient migration governance. Insight into legal pathways addressing both EU Member States’ needs and potential offers of circular and permanent migration schemes in selected partner countries. Enhanced health equity for migrants, including refugees by integrating robust health data into national systems, addressing governance barriers, and tackling intersectional inequities in healthcare access, identifying data/indicators on basic needs in health and sanitation, including as compared to adequate treatment. Comprehensive evaluation of long-term social inclusion and integration strategies, providing evidence-based policy recommendations for labour market access, housing, education, health (including mental health), recognition of qualifications and validation of skills, youth participation, and social, political, and…

The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R01 Clinical Trial Optional mechanism focusing on alcohol health services. This NOFO will broadly focus on closing the treatment gap for individuals with alcohol use disorder (AUD); within this focus, there are five major areas of emphasis: (1) increasing access to treatment for AUD, (2) making treatment for AUD more appealing, (3) examining cost structures and insurance systems, (4) conducting studies on dissemination and implementation of existing evidence-based approaches to treating AUD, and (5) reducing health disparities as a means of addressing the treatment gap in AUD for health disparity populations.

Expected Outcome: This action will support and accelerate the development and adoption of European and international standards for quantum technologies, enhancing interoperability quality/reliability assurance, and trust in quantum systems. It will strengthen Europe's leadership in the global quantum standardisation landscape and ensure that European industrial and research priorities are well represented and integrated into emerging standards. Expected outcomes include: Delivery of concrete, EU-relevant pre-normative standards and technical specifications across quantum computing, communication, and sensing. Substantial contribution of European stakeholders, notably SMEs and start-ups in international standardisation bodies (e.g., ISO/IEC, ITU-T, ETSI), with alignment to EU industrial strategies. Promotion of cross-sectoral interoperability through standardised interfaces, control protocols, reliability in operating conditions and benchmarking methodologies, reducing market fragmentation and technical barriers. Creation of practical support tools such as user guidelines, training modules, and best practices to accelerate the uptake and implementation of quantum…

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for projects to expand, improve, or transform the utility of mammalian cancer and tumor models for translational research. With this NOFO, the NCI intends to encourage submission of projects devoted to demonstrating that mammalian models or their derivatives used for translational research are robust representations of human biology, are appropriate to test questions of clinical importance, and provide reliable information for patients' benefit. These practical goals contrast with the goals of many mechanistic, NCI-supported R01 projects that employ mammals, or develop and use mammalian cancer models, transplantation tumor models, or models derived from mammalian or human tissues or cells for hypothesis-testing, non-clinical research. Among many other possible endeavors, applicants in response to this FOA could propose demonstrations of how to overcome translational deficiencies of mammalian oncology models, define new uses of mammalian models or their genetics for unexplored translational challenges, advance standard practices for use of translational models, test approaches to validate and credential models, or challenge current practices for how models are used translationally

The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R01 Clinical Trial Required mechanism focusing on alcohol treatment and recovery research. This NOFO will focus broadly on topics relevant for treatment of and recovery from alcohol use disorder (AUD), including: medications development, precision medicine, behavioral therapies and mechanisms of behavioral change (MOBC), recovery, translational research, and innovative methods and technologies for AUD treatment and recovery.

COE for Technical Training and Human Performance

The National Human Genome Research Institute (NHGRI) seeks to broaden the types of knowledge, skills, expertise, experience, and perspectives brought to bear in research addressing the ethical, legal and social implications (ELSI) of advances in human genetics or genomics. This Notice of Funding Opportunity (NOFO) solicits UM1 applications from domestic organizations located in the United States and its territories that received less than $30 million per year in total NIH funding for the past three fiscal years. These organizations are underrepresented among those receiving NHGRI funding for ELSI research. The Building Partnerships and Broadening Perspectives to Advance Ethical, Legal, and Social Implications (ELSI) Research (BPAER) Program will support: 1) transdisciplinary ELSI research addressing timely, complex, and understudied topics, 2) the establishment of research teams that include representatives from relevant communities who are affected by and have an interest in the proposed research, 3) research capacity building to develop, conduct and sustain ELSI research, and 4) workforce development opportunities for early career scholars, research team members, and other research project staff. Transdisciplinary ELSI research projects require involvement from two or more fields of knowledge and use of multiple research approaches. Relevant communities must be actively and meaningfully involved on ELSI research teams across all phases of proposed research projects. Research capacity building plans must be informed by a needs assessment. Given the complex structure, a strategic management plan, evaluation plan, and sustainability plan are required to ensure successful completion of the program.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this NIDCD R25 program is to support educational activities that help recruit individuals with specific specialty or disciplinary backgrounds to research careers in biomedical, behavioral and clinical sciences.

UK registered businesses can apply for a share of up to £10 million for industrial research projects to explore industrial strategy aligned Createch innovation. This funding is from Innovate UK.

NIOSH is encouraging the submission of an application from qualified organizations for a National Center for Construction Safety and Health Research and Translation. Applicants are encouraged to propose multidisciplinary approaches and coordination for impactful applied and intervention research, hazard identification, and controls; develop partnerships for implementing prevention and intervention activities; and serve as a leader in research translation and research-to-practice for the protection of construction workers in the U.S. The Center will accomplish these goals by integrating and advancing research, research translation, best practices, policy and guidance, and capacity building. Center work should consider the NIOSH strategic plan and NORA construction research objectives. Center structure should take advantage of diverse scientific resources and focus on national worker safety and health issues. Centers should emphasize the creation and implementation of evidence-based solutions that address important construction industry safety and health problems. Collaborations with other academic institutions, nonprofit organizations, and other occupational safety and health-focused groups are expected. Applicants must concisely describe the occupational health burden of important safety and health issues in the construction industry and discuss how focused research and outreach activities will help alleviate the burden and reduce numbers. Applicants should also clearly articulate the anticipated impacts of the Center’s proposed work, both during the project period and beyond.

This funding opportunity aims to support high risk clinical trials for the development of in vivo high-resolution structural and functional imaging technologies for the living human inner ear. Proposed projects should focus on improving the resolution of current imaging techniques or developing new imaging techniques that can visualize inner ear structures in vivo with significantly greater detail and accuracy than currently possible. Structural and functional aspects, including visualizing dynamic elements, are important to developing new and improved techniques. Projects may also focus on developing new imaging probes or contrast agents that can enhance visualization of the inner ear structures. Research supported in response to this RFA is expected to significantly advance the ability to visualize auditory and vestibular components, such as hair cells, otoliths, membranes, ions, and vasculature, in detail in awake patients in a clinical setting using non-invasive techniques. To achieve this goal, a multidisciplinary team approach that takes advantage of the expertise of each team member is highly encouraged. Studies in humans must be proposed to develop,advance, or test the needed technology. Any intermediate studies must articulate a clear path of the proposed methodology to application in awake humans or define the limitations and the usefulness in anesthetized humans.

This funding opportunity aims to support the development of in vivo high-resolution structural and functional imaging technologies for the living human inner ear. Proposed projects should focus on improving the resolution of current imaging techniques or developing new imaging techniques that can visualize inner ear structures in vivo with significantly greater detail and accuracy than currently possible. Both structural and functional aspects, including visualizing dynamic elements are important to development of new and improved techniques. Projects may also focus on developing new imaging probes or contrast agents that can enhance visualization of the inner ear structures. Ultimately, research supported in response to this RFA is to encourage technologies that allow, for example, structures such as hair cells, otoliths, membranes, ions, and vasculature to be viewed in detail in awake patients in a clinical setting using non-invasive techniques. To achieve this goal, a multi-disciplinary team approach that takes advantage of the expertise of each team member is highly encouraged. Studies in humans and intermediate studies in animals, but not non-mammalian species, may be proposed to develop or advance the needed technology. Any intermediate studies must articulate a clear path of the proposed methodology to application in awake humans or define the limitations and the usefulness in anesthetized humans.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to encourage individuals who have not had substantial biomedical research experience, or who have the potential to significantly benefit from additional biomedical research experience to pursue further studies or careers in research. To accomplish the stated over-arching goal, this NOFO will support educational activities with a primary focus on: (1) Research Experiences, (2) Curriculum or Methods Development and (3) Outreach. The NCI’s mission is to conduct and support research, training, health information dissemination, and other programs concerning cancer. This funding opportunity seeks to facilitate educational activities that encourage students to become knowledgeable about cancer and available to focus on cancer later in their careers. To promote broad interest in pursuing a career in biomedical research via early intervention strategies, the NCI Youth Enjoy Science (YES) Program will support efforts to create and maintain an institutional program to engage grades 6-12 and/or undergraduate students in cutting edge cancer research experiences. The proposed institutional programs may also provide research experiences for the grade 6-12 teachers and undergraduate faculty members. The goals are to inspire interest in biomedical sciences, help envision research as a career path, and strengthen practical research and career skills. In alignment with these goals, institutions may develop unique programs that capitalize on their research strengths and are responsive to their target populations.

This Notice of Funding Opportunity (NOFO) invites eligible academic or research institutions to apply for funding support to purchase latest scientific equipment that will enhance and modernize research-supporting operations of existing shared biomedical research facilities. Targeted are laboratory research core facilities, animal research facilities, and other similar shared-use research spaces. The goal of this NOFO is to strengthen research-auxiliary activities of biomedical research facilities and to enhance the efficiency of their operations. The NOFO does not support the purchase of scientific research instruments or their components, nor components of building-level infrastructure equipment that indirectly support research activities.

The U.S. Fish and Wildlife Service (Service) requests interested entities to submit research, restoration, and Regional Project proposals for the restoration of the Great Lakes Basin fish and wildlife resources, as authorized under the Great Lakes Fish and Wildlife Restoration Act (16U.S.C. 941c). The purpose of the Great Lakes Fish and Wildlife Restoration Act (GLFWRA) is to provide assistance to States, Indian Tribes, and other interested entities to encourage cooperative conservation, restoration, research, and management of the fish and wildlife resources and their habitats in the Great Lakes Basin. Supported in part by the Great Lakes Restoration Initiative, we expect approximately $3.5 million to support proposals this fiscal year. Available funding and proposal awards are subject to final Congressional appropriations for Fiscal Year 2026. Up to 33 and one-third percent of the total Congressional appropriation to the GLFWRA is eligible to fund Regional Project proposals. Expected award funding for Regional Project proposals is between $200,000 to $500,000. Successful restoration and research proposals have ranged from $2,000 to $500,000 with the average proposal at $217,843. Expected award funding for restoration and research proposals is between $10,000 and $250,000. Selected restoration and research proposals and Regional Project proposals will be awarded funding for the duration of the proposal via a grant or cooperative agreement between the recipient and the Service. Funding will be made available once the official award letter has been received by the successful applicant and the performance period has started. Continuation of proposals funded in previous fiscal years are eligible but will be considered and reviewed as a new proposal. Restoration and research proposals will be awarded a grant agreement and Regional Project proposals will be awarded a cooperative agreement under this announcement. Cooperative Ecosystem Studies Units (CESU) Network partners that submit Regional Project proposals that qualify as CESU proposals will be subject to the CESU indirect cost rate cap. Regional Projects are authorized activities of the Service related to fish and wildlife resource protection, restoration, maintenance, and enhancement impacting the resources of multiple States or Indian Tribes with fish and wildlife management authority in the Great Lakes Basin. The two-page restoration and research pre-proposals and Regional Project proposals are submitted to the Service to determine eligibility and the Proposal Review Committee (PRC) scores and ranks the proposals using GLFWRA Review Criteria (Review Criteria). Successful restoration and research pre-proposal applicants are invited to submit full proposals, which are scored and ranked by the PRC using the Review Criteria. The PRC recommends the restoration and research full proposals and Regional Project proposals for funding to the Service"s Midwest Region 3 Regional Director for approval. Successful restoration and research and Regional Project proposal applicants can anticipate receiving an official grant or cooperative agreement award letter between January and March 2027.

Expected Outcome: Project results are expected to contribute to some or all of the following outcomes: Identification and analysis of potential new security risks related to innovative technologies being deployed in the urban and peri-urban environments; Innovative and modern tools to identify and measure changes in urban and peri-urban areas caused by the green transition, insofar as they concern security and possible resilience approaches; Verification of measures countering potential safety and security risks, hazards and challenges arising in areas hosting green technologies; Contribution to building awareness and societal acceptance for the safety and security aspects of the green transition; Impacts of incidents involving new and emerging technologies are examined, including environmental and climate risks; Security, safety and resilience aspects of the supply chains of green technologies are analysed, including the technological and resource dependencies, and their aligning with the European strategic autonomy principle; Authorities and critical infrastructure operators are equipped with efficient evaluation methodologies for safe and secure deployment and integration of…

Expected Outcome: Project results are expected to contribute to all of the following expected outcomes: Police Authorities in Europe are empowered with modern, accessible and validated tools, methodologies and training curricula to anticipate and cope with the misuse of new and emerging technologies for criminal purposes, with the aim to facilitate prevention, detection, efficient data access and investigation of criminal offences in a lawful manner and with full respect of fundamental rights, including the right to protection of personal data and to privacy; Reinforced interdisciplinary collaboration at the European level through the establishment of partnerships among technologists, policymakers and Police Authorities, resulting in a holistic understanding of the challenges posed by emerging technologies and in sharing of best practices; Clear guidelines and frameworks are created, including on procedures and rules, that ensure lawful access to data, balancing the needs of security with respect for privacy and that foster a European approach to the related challenges for the police and the judiciary. Scope: New and emerging technologies (e.g., new communication technologies,…

Expected Outcome: Project results are expected to contribute to some or all of the following expected outcomes: Integrated single-hazard systems into multi-hazard next generation predictive models to assess cascading effects (e.g., heatwave, floods, droughts, landslides, heavy rain) and interactions across meteorological, geophysical, and technological hazards; Enhanced hazard forecasting and response through research on model integration and platform interoperability; Development of holistic risk and resilience metrics to support multi-hazard prevention strategies, encompassing main physical, economic and social effects; Improvement of analysis models considering evolving vulnerability state, due to cascading and cumulative effects, through numerical simulations and experimental tests, possibly also supported by AI applications; Collected reliable data (same granularity and format) and ways to share and analyse it. The interoperability of all kinds of systems and information sharing is crucial, based on the need-to-know principle; Improved knowledge/experience-sharing from past emergencies to cope with future emergencies, also strengthening trans-national knowledge and data…

Expected Outcome: Project results are expected to contribute to some or all of the following expected outcomes: Police Authorities in Europe are equipped with specialised skills and technologies to counter an increase in illegal activities related to the climate change and the emergence of new (opportunistic) criminal patterns; Improved understanding by policymakers of the effects of climate change on law enforcement with a view of developing related effective European policies; improved knowledge of the impacts of climate change phenomena on social dynamics which can raise demands from public authorities to keep public order, moving beyond traditional perspectives about crime and terrorism. Scope: Global climate change is a megatrend expected to affect our societies over the next decade. As stated in “Germany: National interdisciplinary climate risk assessment” [1] , “We are already living in the climate crisis. This brings substantial security risks at global and national levels. (...) Anyone thinking about security needs to think about climate as well”. Climate change will affect European law enforcement in various ways [2] , [3] . Notably, it is likely to create new…

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated, early phase, clinical trials of natural products (i.e., botanicals, dietary supplements, and probiotics), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. Under this NOFO, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support decisions about further development or testing of the natural product. This NOFO will provide up to 3 years support for studies to replicate the impact of the natural product on target engagement when used by humans, and assess whether there is an association between the degree of the impact on target engagement and functional or clinical outcomes in a patient population. Applications are encouraged to design studies to determine how to optimize the impact of the natural product on target engagement by optimizing the delivery of the natural product through examination of different doses or formulations. In addition, applications can be designed to combine the natural product with another treatment approach that is known to engage the same target; or study the impact of the natural product in a target population that is more responsive. Clinical trials submitted under this NOFO are expected to be hypothesis based, milestone-driven, and directly related to the research priorities and mission of NCCIH. This R33 funding mechanism is intended to accelerate the translation of emerging basic science findings about natural products into early-stage clinical testing to determine whether continued clinical research is warranted. This NOFO will not support efficacy or effectiveness trials, nor will

Expected Outcome: Project results are expected to contribute to all of the following expected outcomes: Housing-led approaches [1] aligned with the NEB are made available to stakeholders involved in tackling homelessness [1] . Robust evidence on NEB-aligned housing-led approaches tackling homelessness (including people temporarily hosted by acquaintances and family) to inform the development and/or update of policies and services for prevention and early intervention in the context of the green transition [1] in neighbourhoods [1] . Scope: Social and affordable housing is being advanced in the EU, including through the Affordable Housing Initiative [5] . Despite efforts, current policies for the green transition are failing to adequately address the housing crisis. Homelessness remains a structural challenge across Europe, with negative impacts on both individuals experiencing it (e.g. physical and mental health, social and economic conditions) and neighbourhood communities [1] (e.g. pressure on public services, erosion of social fabric [1] , etc.). Research and innovation gaps in tackling homelessness range from data collection (i.e. the variety of approaches to defining,…

Expected Outcome: Project results are expected to contribute to some or all of the following expected outcomes: Development of innovative tools and methodologies to monitor and improve risk awareness across society, integrating diverse community perspectives and leveraging advanced technologies; Development and uptake solutions and tools for the successful increase of safety culture and societal resilience of communities with concrete material, while considering also the inclusion and protection of marginalized populations in disaster scenarios; Creation of comprehensive, inclusive preparedness plans that involve all societal sectors and governance levels, ensuring coordinated and effective responses to disasters (such as from early warning to early action), including scarcity of resources; Establishment of a resilient, adaptive response framework that enhances collaboration between public authorities, communities, and private sectors, improving overall disaster resilience. Scope: Building on the whole-of-society and whole-of-government approach, this topic should contribute to enhancing risk awareness and disaster preparedness through the development of innovative tools,…

Expected Outcome: Project results are expected to contribute to some or all of the following expected outcomes: Improved understanding of links between addictions and crime, including drivers of criminality; Innovative and effective solutions, including training curricula, for Police Authorities in Europe and relevant Civil Society Organisations (or Non-Governmental Organisations) to prevent addictions and related crimes, with a special attention to young people at risk; Evidence-based support to modernising European criminal justice system’s approach when dealing with addiction-related offenses; Novel approaches of collaboration between different stakeholders, primarily Police Authorities in Europe and Civil Society Organisations (or Non-Governmental Organisations), to increase communities’ addiction resilience, security and safety. Scope: A close and complex relationship exists between addictions, such as gambling, drug or alcohol use, and crime (e.g., criminals are often under the influence of drugs while committing crimes, gamblers or drug users commit crimes to pay for their debts or drugs). In this topic, successful proposals are expected to analyse the specific nexus…

Expected Outcome: Project results are expected to contribute to some or all of the following expected outcomes: Accelerated adoption of high-TRL (Technology Readiness Level) disaster risk solutions across diverse sectors; Facilitated integration of innovative technologies into existing disaster prevention, preparedness, response, and recovery frameworks; Promoted collaboration among stakeholders to scale proven solutions and enhance resilience; Addressed barriers to deployment, ensuring accessibility and usability of advanced DRS technologies; Strengthened evidence-based decision-making through demonstration and validation of high-TRL solutions in real-world scenarios; Promoted visibility of civil security research results. Scope: This topic aims to foster the widespread adoption and integration of high-TRL (Technology Readiness Level) disaster risk solutions (DRS) across multiple sectors, enhancing societal resilience to various hazards, including climate. The focus is on overcoming barriers to deployment, ensuring accessibility, and strengthening collaboration among stakeholders to drive innovation uptake. Projects should promote the adoption of high-TRL solutions by public and…

NIGMS will support innovative educational activities designed to equip participants with technical, operational, or professional skills required for careers in the biomedical research workforce. Activities must be open to the broader biomedical research community and may focus on participants at one or more career stages from undergraduates to professionals (for example faculty, staff scientists). Funded programs will have a robust program leadership structure, participant recruitment plan, and evaluation and dissemination plans.

Expected Outcome: Project results are expected to contribute to all of the following expected outcomes: Increased understanding of European policy makers, research community, biotech companies, and relevant security practitioners of the threat of bioterrorism and of synthetic biology, including a thorough lawful analysis of what needs to be monitored in this context, what needs to be regulated and how; Awareness raised within the related scientific community how research in synthetic biology can be used for malicious purposes. Scope: The rising threat of bioterrorism is driven by recent scientific advancements, notably by growing accessibility of synthetic biology, genetic engineering, related commercial services and public databases, which in turn enhance their obtainability to non-state actors and individuals with malicious intentions. The proliferation of do-it-yourself biohacking and community laboratories, including gene editing and sequencing technology, dropping costs of equipment and increased simplicity of use may inadvertently facilitate knowledge and skills dissemination about biological threats and open new pathways for bioterrorism. Challenges in detection,…

Objective: 1. Background The EDCTP Prizes 2026-2027 are recognition prizes funded under Horizon Europe. Prizes are financial contributions given as rewards following the publication of a contest. A ‘recognition prize’ is used to recognise past achievements and outstanding work after it has been performed, whereas an ‘inducement prize’ is used to spur investment in a given direction, by specifying a target prior to the performance of the work. Applications will have to clearly state the involvement of the applicants in the research and innovation activities within the remit of the Global Health EDCTP3 programme. Applicants will have to provide proof of eligibility and a written presentation of the achievements, which will be presented to an independent panel of experts for evaluation. The amounts of the prizes are specified in section 3. They are not linked to the costs incurred by the winner. 2. EDCTP3 Prizes 2026 and related award criteria The prizes will be awarded to the entry that, in the opinion of the independent expert jury, demonstrates having best addressed the cumulative criteria specified under the respective descriptions below. Applications will be graded on a total of…

This funding opportunity announcement (FOA) encourages applications for institutional research career development (K12) programs that propose to support intensive supervised research training and career development experiences for clinician scientists (Scholars) leading to research independence in the area of substance use and substance use disorder research.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to accelerate the adoption and validation of molecular/cellular/imaging markers (referred to as "markers" or "biomarkers") and assays for cancer detection, diagnosis, prognosis, monitoring, and prediction of response or resistance to treatment, as well as markers for cancer prevention and control. This NOFO will also support the validation of pharmacodynamic markers and markers of toxicity. Applicants to this NOFO must have an assay(s) whose performance has been analytically validated in specimens similar to those for the intended clinical use of the marker(s) and assay(s). As chemotherapies and/or radiation therapies are increasingly combined with immunotherapies to enhance the durability of anti-cancer responses, assays for measuring multiple markers, including immune markers, can be developed and validated simultaneously. The UH3 mechanism will support the clinical validation of established assays for up to 3 years using specimens from retrospective or prospective clinical trials or studies. This NOFO may be used to validate existing assays for use in other trials, observational studies, or population studies. Efforts to harmonize clinical laboratory tests, including investigation into the performance and reproducibility of assays across multiple clinical laboratories, are also appropriate for this funding opportunity. Projects proposed for this NOFO will require multi-disciplinary interaction and collaboration among scientific investigators, oncologists, statisticians, and clinical laboratory scientists. This NOFO is not intended to support early-stage development of technology or the conduct of clinical trials but is intended for validation of assays to the point where they could be integrated into clinical trials/studies as investigational assays.

Expected Outcome: Project results are expected to contribute to all of the following expected outcomes: Robust evidence on how inhabitants experience their neighbourhood [1] and the impact of these experiences on their health and well-being. The research informs policies, strategies, neighbourhood planning and procurement for the green transition [1] of neighbourhoods, including their nature-positive [3] transformation and climate resilience. Scope: Neighbourhoods are human-social constructs and environments. They are shaped by complex inter-connections and interdependencies of human and non-human actors in the natural and built environment [1] they comprise. An increasing body of research is looking at the relationship between people and the built environment, from neuro-architectural aspects of space to atmosphere and ambiance aspects in urban design and planning, influencing also the perception of beauty. Digitalisation is also allowing to understand, map and enhance how inhabitants experience the built environment. Yet, more evidence is needed on how inhabitants react to and identify with their neighbourhoods as well as the effects of these experiences on their physical and…

Expected Outcome: Project results are expected to contribute to all of the following expected outcomes: Demonstrated approaches aligned with NEB allow architects, designers, spatial planners and neighbourhood [1] decision makers to ensure an efficient and effective integration of user perspectives in the spatial design and/or transformation of public spaces. The demonstrated approaches deliver positive climate, environmental, social and cultural impact (such as addressing inequalities and enhancing social cohesion, community [1] resilience, civic engagement and a sense of security, ownership and belonging). Scope: The design of neighbourhood public spaces defines their functionality, but also other aspects such as power dynamics and sense of belonging. A fair green transition [1] calls for neighbourhood public spaces to be designed and managed for diverse users. Integrating new methods (such as research-by-design, security-by-design [4] , or life-centric design) in the architectural design and spatial planning of public space can help reflect on the values, practices and stakeholder relations that underpin the design of public spaces; rethink how public spaces are understood;…

Expected Outcome: Project results are expected to contribute to all of the following expected outcomes: An increased number of local authorities systematically identify and quantify vacant, obsolete or underutilised spaces for reuse in neighbourhoods [1] in a context-sensitive way to address local community [1] challenges and needs. Increase in renovated, renatured, or converted spaces that address local community challenges and needs. Scope: Europe’s housing needs, inefficient use of the existing building stock, environmental commitments, and the EU’s goal of “no net land take” by 2050 make a compelling case for reusing the significant number of existing spaces, including buildings and infrastructure, that are vacant, obsolete or underutilised. In Europe, there are, for instance, an estimated 19,000 km² of underutilised brownfield land and 300 km² of vacant or underutilised office space [3] . The reuse of vacant, obsolete or underutilised spaces, following circularity [1] and sufficiency principles, can help address community challenges and needs thanks to their typical proximity and connection to essential infrastructure and services. While vacant, obsolete or underutilised…

Objective: 1. Background The EDCTP Prizes 2026-2027 are recognition prizes funded under Horizon Europe. Prizes are financial contributions given as rewards following the publication of a contest. A ‘recognition prize’ is used to recognise past achievements and outstanding work after it has been performed, whereas an ‘inducement prize’ is used to spur investment in a given direction, by specifying a target prior to the performance of the work. Applications will have to clearly state the involvement of the applicants in the research and innovation activities within the remit of the Global Health EDCTP3 programme. Applicants will have to provide proof of eligibility and a written presentation of the achievements, which will be presented to an independent panel of experts for evaluation. The amounts of the prizes are specified in section 3. They are not linked to the costs incurred by the winner. 2. EDCTP3 Prizes 2026 and related award criteria The prizes will be awarded to the entry that, in the opinion of the independent expert jury, demonstrates having best addressed the cumulative criteria specified under the respective descriptions below. Applications will be graded on a total of…

This announcement invites applications for basic research projects on chemical warfare agents, toxic industrial chemicals, and pesticides that have primary or secondary effects on the nervous system. Chemical threats are toxic compounds that could be used in a terrorist attack or accidentally released from industrial production, storage, or shipping. Projects supported by this NOFO are expected to generate data that elucidate mechanisms of toxicity of these agents, possible new manifestations of toxic exposures, and potential new targets for therapeutic development.

The U.S. Embassy Kuala Lumpur Public Diplomacy Section seeks proposals that advance American leadership, prosperity, and security interests in Malaysia. This program supports initiatives that promote U.S. technological innovation and economic competitiveness, showcase American excellence in sports and education, strengthen ties with exchange program alumni, and position the United States as Malaysia's most trusted international partner.   Priority areas include: advancing U.S. leadership in artificial intelligence and emerging technologies; leveraging major sporting events to demonstrate American excellence; engaging alumni networks to amplify U.S. influence; and promoting American English language education and pathways to U.S. higher education institutions. Programs should demonstrate clear alignment with U.S. national interests, measurable outcomes, and sustainable impact beyond the grant period. Successful proposals will engage influential Malaysian stakeholders, promote American standards, and contribute to making America more prosperous and secure.

Expected Outcome: Project results are expected to contribute to all of the following expected outcomes: Project promoters, public authorities, and investors have a better understanding of the capital market demand and supply dynamics that underlie investments in projects fostering the transformation of neighbourhoods [1] in line with the New European Bauhaus (NEB). Increased investments towards NEB-aligned projects for the sustainable [1] and inclusive [1] transformation of neighbourhoods. Scope: Increased investment in projects for the transformation of neighbourhoods in line with the New European Bauhaus (NEB) may be hindered due to a discrepancy between the demand and supply of capital in terms of size, diversity, returns, and risk. Small-scale NEB-aligned projects typically encounter large, short-term oriented, and highly risk-averse investment funds, which seek investment opportunities able to absorb large amounts of funding, driven by present legislation [4] . Place-based impact investing is an approach that can contribute to investments in NEB-aligned neighbourhood projects by providing risk-adjusted financial returns while creating local social, cultural, aesthetic [5] and…

Expected Outcome: Project results are expected to contribute to some or all of the following expected outcomes: Improved preparedness, evidence-based approaches and response capabilities, along with a strengthened ability to mitigate risks from diverse threats, by integrating validated disruptive technologies into real-world operations; Accelerated adoption of innovative solutions by reducing barriers through rigorous testing and validation, fostering collaboration among public authorities, industry, and researchers to align technologies with real-world needs. Scope: This topic aims to support the integration of disruptive technological innovations [1] into civil security by strengthening research and innovation activities that enhance preparedness, response capabilities, and risk mitigation. A key focus is bridging the gap between early-stage, low Technology Readiness Level (TRL) research and applied security solutions, ensuring that emerging technologies are effectively transitioned into operational use. Proposals should prioritize disruptive solutions that address diverse security threats while improving the efficiency and effectiveness of civil security operations. Emphasis…

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated, early phase, clinical trials of natural products (i.e., botanicals, probiotics, and products marketed as dietary supplements), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. Under this NOFO, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support decisions about further development or testing of the natural product. This NOFO will provide up to three years (R61 phase) of support for milestone-driven testing of pharmacokinetics, bioavailability, and assessment of the natural products effect (i.e., measure of mechanism of action) when used by humans on a specified target measure. If milestones in the R61 phase are achieved, up to 3 years of additional support (R33 phase) may be awarded to replicate the impact of the natural product on target engagement(s) when used by humans and assess whether there is an association between the degree of the impact on the target engagement and clinical outcomes in a participant population. Applications are encouraged to design R33 studies to determine how to optimize the impact of the natural product on the target engagement by optimizing the delivery of the natural product through examination of different doses or formulations. In addition, applications can be designed to combine the natural product with another treatment approach that is known to impact the same target engagement measure; or study the impact of the natural product in a population that is more responsive,

Objective: 1. Background The EDCTP Prizes 2026-2027 are recognition prizes funded under Horizon Europe. Prizes are financial contributions given as rewards following the publication of a contest. A ‘recognition prize’ is used to recognise past achievements and outstanding work after it has been performed, whereas an ‘inducement prize’ is used to spur investment in a given direction, by specifying a target prior to the performance of the work. Applications will have to clearly state the involvement of the applicants in the research and innovation activities within the remit of the Global Health EDCTP3 programme. Applicants will have to provide proof of eligibility and a written presentation of the achievements, which will be presented to an independent panel of experts for evaluation. The amounts of the prizes are specified in section 3. They are not linked to the costs incurred by the winner. 2. EDCTP3 Prizes 2026 and related award criteria The prizes will be awarded to the entry that, in the opinion of the independent expert jury, demonstrates having best addressed the cumulative criteria specified under the respective descriptions below. Applications will be graded on a total of…

The purpose of this initiative is to: (1) support the efforts by R15-eligible Principal Investigators (PIs) to conduct rigorous basic and/or mechanistic pain research projects; (2) promote integrated, interdisciplinary research partnerships between R15-eligible PIs and additional investigators from U.S. domestic institutions, and (3) enhance the pain research environment at the R15-eligible institution for health professional trainees or undergraduate and/or graduate students by actively engaging them in the proposed pain research projects.

The Public Diplomacy Section of U.S. Embassy Muscat announces an open competition to support projects that advance U.S. foreign policy priorities in Oman while strengthening the long-standing partnership between the United States and the Sultanate of Oman. This Annual Program Statement outlines strategic funding priorities, eligibility criteria, and application guidelines for grants ranging from $1,000 to $50,000, with project durations of up to 12 months.   Successful proposals should clearly demonstrate how their projects support U.S. public diplomacy goals; showcase American excellence, expertise, innovation, and values, and strengthen the bilateral relationship.   The goals of U.S. policy in the region are to: 1) secure opportunities that advance U.S. commercial and strategic interests; 2) promote trusted cooperation in emerging technologies, innovation, and space; and 3) deepen people-to-people ties that showcase American excellence. Applicants should clearly explain how their projects support U.S. public diplomacy goals, strengthen the U.S.-Oman partnership, and highlight American expertise, leadership, and innovation.   Programs should include a clear U.S. element, such as engagement with U.S. experts, institutions, companies, universities, artists, athletes, alumni, or professional networks; the use of American models, standards, technologies, or best practices; or activities that increase understanding of the United States and its partnership with Oman. Program Description 1.      Project Background, Goals, and Objectives   The Public Diplomacy Section of U.S. Embassy Muscat is pleased to invite applications for federal assistance funding opportunities, pending availability of funds, through its Public Diplomacy Small Grants Program. This Annual Program Statement outlines the Embassy’s funding priorities, strategic themes, and procedures for submitting proposals. Applicants should carefully follow all instructions below.   The Public Diplomacy Section seeks proposals for programs that advance U.S. foreign policy priorities in Oman while strengthening the long-standing partnership between the United States and Oman. Competitive proposals should clearly demonstrate how the proposed project makes the United States safer, stronger, or more prosperous; and showcases American excellence, expertise, innovation.   Programs should include a clear U.S. element, such as engagement with U.S. experts, institutions, companies, universities, artists, athletes, alumni, or professional networks; the use of American models, standards, technologies, or best practices; or activities that increase understanding of the United States and its role as a trusted partner for Oman.    2.      Program Objectives   Applicants may submit proposals that address one of the program goals below. Proposals should focus on one or more of the priority outcomes, but applicants may also recommend their own objectives if they clearly align with U.S. Embassy Muscat priorities.   Goal 1. Advancing U.S.-Oman Commercial Ties, and Shared Prosperity:   This goal supports programs that make the United States more prosperous by expanding U.S.-Oman economic cooperation, strengthening commercial ties, and highlighting the value of trusted U.S. expertise, technology, standards, and business practices. Projects may support Omani entrepreneurs, students, business leaders, and institutions in sectors that advance shared economic priorities, including innovation, trade and investment, tourism, logistics, clean energy, creative industries, and other areas linked to Oman’s economic diversification goals.   Programs should demonstrate how engagement with U.S. experts, companies, universities, or professional networks can help Omani audiences develop practical skills, build market-oriented solutions, and identify opportunities for long-term U.S.-Oman commercial cooperation.   Project Audience(s): Entrepreneurs, students, business professionals, chambers of commerce, academic institutions, economic organizations, youth, and relevant civil society partners.   Priority Outcome(s): Applicants may focus on one or more of the outcomes listed below. Applicants are encouraged to propose additional objectives and innovative activities that address this priority program area.   Increased awareness among Omani audiences of opportunities for U.S.-Oman trade, investment, entrepreneurship, and private-sector collaboration. Stronger connections between Omani entrepreneurs, students, or business leaders and U.S. experts, companies, universities, or professional networks. Greater understanding of American business practices, innovation models, market-based solutions, and trusted U.S. standards in sectors important to Oman’s economic growth. New partnerships or project ideas that position the United States as a preferred partner for economic cooperation, entrepreneurship, and commercial innovation in Oman.   Goal 2. Strengthening Sports Diplomacy, Youth Leadership, and Major-Event Expertise:   This goal supports programs that use sports to advance U.S. public diplomacy goals, strengthen people-to-people ties, and share American excellence in sports management, coaching, athletic development, sports entrepreneurship, and major-event planning. As the United States prepares to host major global sporting events, including the Olympics, proposals may draw on U.S. experience in organizing, managing, and leveraging sports events to support youth development, community engagement, tourism, and economic opportunity.   Projects should demonstrate how U.S. sports expertise can benefit Omani athletes, coaches, sports institutions, youth organizations, and communities while strengthening positive perceptions of the United States and expanding long-term U.S.-Oman cooperation in the sports sector.   Project Audience(s): Youth, athletes, coaches, sports federations and clubs, schools, universities, sports entrepreneurs, community organizations, and relevant public or private-sector partners. Priority Outcome(s): Applicants may focus on one or more of the outcomes listed below. Applicants are encouraged to propose additional objectives and innovative activities that address this priority program area. Increased exchange of U.S. and Omani expertise in sports management, coaching, leadership, athletic development, and major-event planning. Expanded professional connections between Omani sports institutions, coaches, athletes, or youth organizations and U.S. sports experts or institutions. Greater understanding of how sports diplomacy can support entrepreneurship, education, health, tourism, and community development. Increased recognition of the United States as a global leader in sports innovation, major-event management, and sports diplomacy.   Goal 3. Showcasing American Excellence in Culture, Heritage, and Creative Industries:   This goal supports programs that showcase American excellence, creativity, innovation, and cultural leadership while strengthening cultural understanding between the United States and Oman. Projects may connect American and Omani artists, cultural institutions, heritage professionals, designers, filmmakers, musicians, writers, museum professionals, and creative entrepreneurs. Programs may highlight the role of culture and heritage in strengthening national identity, mutual understanding, tourism, and economic opportunity. Projects may also showcase U.S. excellence in creative industries, including film, music, design, museums, digital storytelling, gaming, publishing, architecture, cultural entrepreneurship, and other creative sectors where the United States has global influence. Projects under this goal should support marking the 250th anniversary of the founding of the United States. Freedom 250 programs should highlight American history, constitutional traditions, innovation, entrepreneurship, creativity, civic ideals, and the people-to-people ties that connect the United States and Oman.   Project Audience(s): Artists, cultural institutions, museums, heritage professionals, students, youth, creative entrepreneurs, educators, writers, filmmakers, designers, alumni, and the public.   Priority Outcome(s): Applicants may focus on one or more of the outcomes listed below. Applicants are encouraged to propose additional objectives and innovative activities that address this priority program area. Increased collaboration between U.S. and Omani cultural, creative, or heritage professionals and institutions. Greater public understanding of the United States through American arts, culture, history, innovation, and creative industries. Strengthened skills among Omani artists, cultural professionals, or creative entrepreneurs through engagement with U.S. experts, institutions, or models. Programs that connect Omani heritage and American creative expertise through exhibitions, workshops, public programs, digital storytelling, or joint cultural initiatives. Freedom 250 programs that increase awareness of American history, constitutional freedoms, innovation, entrepreneurship, and the long-standing U.S.-Oman partnership.   Goal 4. Advancing Emerging Technologies, Space Cooperation, and Innovation:   This goal supports programs that make the United States safer, stronger, and more prosperous by expanding U.S.-Oman cooperation in emerging technologies, space science, and innovation. Projects should showcase U.S. leadership in science, technology, and space while supporting Omani talent, institutional capacity, and innovation ecosystems in areas of shared strategic interest.   Projects may focus on artificial intelligence, cybersecurity, data science, digital transformation, advanced manufacturing, biotechnology, clean technology, trusted digital infrastructure, satellite technology, Earth observation, STEM education, commercial space, or space entrepreneurship. Competitive proposals should include a clear U.S. connection, such as collaboration with U.S. universities, research institutions, technology companies, NASA-related educational resources, private-sector innovators, U.S. exchange alumni, or American experts.   Programs should demonstrate how U.S. expertise, standards, and innovation models can help Omani students, researchers, entrepreneurs, educators, and professionals develop practical skills, build trusted partnerships, and contribute to long-term U.S.-Oman cooperation in technology and space.   Project Audience(s): Students, youth, universities, researchers, entrepreneurs, technology professionals, STEM organizations, science communicators, educators, civil society organizations, and relevant public or private-sector partners.   Priority Outcome(s): Applicants may focus on one or more of the outcomes listed below. Applicants are encouraged to propose additional objectives and innovative activities that address this priority program area. 1.      Increased understanding among Omani audiences of U.S. leadership, standards, and best practices in emerging technologies, advanced technologies, space science, and innovation. 2.      Stronger connections between Omani students, researchers, entrepreneurs, or professionals and U.S. technology, STEM, or space-related experts, institutions, and innovation networks. 3.      Practical skills development in areas such as artificial intelligence, cybersecurity, data analysis, digital entrepreneurship, technology governance, STEM education, satellite technology, or space entrepreneurship, utilizing American platforms and providers. 4.      Greater awareness of trusted, responsible, and secure U.S. technology solutions that support innovation, economic growth, institutional resilience, and shared security. 5.      Programs that encourage U.S.-Oman collaboration in space education, Earth observation, climate and environmental monitoring, commercial space, science communication, or related fields.

This notice of funding opportunity (NOFO) invites applications for investigator-initiated clinical trials of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions) in NCCIH-designated areas of high research priority. Applications submitted under this NOFO are expected to propose a multisite feasibility clinical trial that will provide new information that is scientifically necessary for the planning and conduct of a subsequent clinical efficacy or effectiveness study, pragmatic trial, or dissemination and implementation trial within NCCIHs mission. NCCIH expects that applications to this NOFO will describe the planned future clinical trial and in so doing demonstrate that the proposed (R01) research is scientifically necessary to design or plan the subsequent fully powered, full-scale clinical trial. Under this R01, the data collected should be used to fill gaps in scientific knowledge, including, but not limited to the following: assessing whether the intervention can be delivered with fidelity across sites; demonstrating feasibility of recruitment, accrual, and randomization of participants across sites; demonstrating participant adherence to the intervention, as well as retention of participants throughout the study across sites; refining and assessing the feasibility of protocolized multimodal interventions, and/or demonstrating feasibility of data collection across sites in preparation for a future fully powered, multisite efficacy or effectiveness trial. The need for multisite feasibility trials is expected to be justified by sufficient preliminary data from previous single site feasibility or acceptability trial(s) or the published literature. The data collected should be used to fill gaps in scientific knowledge and be necessary to develop a competitive fully powered multisite clinical trial that has the potential to make a significant impact on public health.

Objective: 1. Background The EDCTP Prizes 2026-2027 are recognition prizes funded under Horizon Europe. Prizes are financial contributions given as rewards following the publication of a contest. A ‘recognition prize’ is used to recognise past achievements and outstanding work after it has been performed, whereas an ‘inducement prize’ is used to spur investment in a given direction, by specifying a target prior to the performance of the work. Applications will have to clearly state the involvement of the applicants in the research and innovation activities within the remit of the Global Health EDCTP3 programme. Applicants will have to provide proof of eligibility and a written presentation of the achievements, which will be presented to an independent panel of experts for evaluation. The amounts of the prizes are specified in section 3. They are not linked to the costs incurred by the winner. 2. EDCTP3 Prizes 2026 and related award criteria The prizes will be awarded to the entry that, in the opinion of the independent expert jury, demonstrates having best addressed the cumulative criteria specified under the respective descriptions below. Applications will be graded on a total of…

The National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), invites grant applications for Education and Research Centers (ERCs) that are focused on occupational safety and health training. NIOSH is mandated to provide an adequate supply of qualified personnel to carry out the purposes of the Occupational Safety and Health Act, and the ERCs are one of the primary means for meeting this mandate. ERCs are academic institutions that provide high-quality interdisciplinary graduate and post-graduate training, research training, continuing education, and outreach in the core occupational safety and health disciplines of industrial hygiene, occupational health nursing, occupational medicine, and occupational safety, as well as allied disciplines. Research and research training are integral components of ERCs, with ERC faculty and NIOSH trainees conducting research on issues related to the NIOSH National Occupational Research Agenda (NORA) and emerging issues to advance the field of occupational safety and health. NIOSH ERCs have regional presence to further diversify the occupational safety and health profession through their core values, mission statements, and outputs. ERCs serve as resources for our nation's workforce through continuing education, outreach and strong collaboration with professional associations, worker advocacy groups, businesses, industries, and public health agencies. ERCs work with other institutions and organizations, including Minority Serving Institutions and other NIOSH supported training programs to have a positive impact on worker health, safety, and well-being.

Objective: 1. Background The EDCTP Prizes 2026-2027 are recognition prizes funded under Horizon Europe. Prizes are financial contributions given as rewards following the publication of a contest. A ‘recognition prize’ is used to recognise past achievements and outstanding work after it has been performed, whereas an ‘inducement prize’ is used to spur investment in a given direction, by specifying a target prior to the performance of the work. Applications will have to clearly state the involvement of the applicants in the research and innovation activities within the remit of the Global Health EDCTP3 programme. Applicants will have to provide proof of eligibility and a written presentation of the achievements, which will be presented to an independent panel of experts for evaluation. The amounts of the prizes are specified in section 3. They are not linked to the costs incurred by the winner. 2. EDCTP3 Prizes 2026 and related award criteria The prizes will be awarded to the entry that, in the opinion of the independent expert jury, demonstrates having best addressed the cumulative criteria specified under the respective descriptions below. Applications will be graded on a total of…

Expected Outcome: Integration of quantum computing into data pre-processing pipelines and learning workflows for data-heavy or computationally intensive tasks, demonstrating clear improvements in processing speed, computational complexity, modelling accuracy, and reduced sample requirements at scales achievable with NISQ-era devices, Reliable and scalable Quantum Machine Learning (QML) models and algorithms, integrated with existing AI frameworks and pipelines, enabling faster data processing, improved prediction accuracy, and enhanced computational capabilities, Validated quantum-enhanced AI methods demonstrating measurable improvements over classical baselines in terms of speed, accuracy, data efficiency, complexity, or scalability, supported by rigorous benchmarking and complexity analysis, Robust, noise-aware QML techniques suitable for NISQ hardware , including error-mitigation strategies and algorithmic adaptations that improve reliability, performance, and reproducibility on real quantum processors, Demonstrators or proof-of-concept applications showcasing the relevance of QML for real-world challenges (e.g. climate and environmental modelling, Earth observation, healthcare…

The purpose of this modification is to clarify the meaning of the Program Policy Factors in Section V.C. To obtain a copy of the Notice of Funding Opportunity (NOFO) please go to the ARPA-E website at https://arpa-e-foa.energy.gov. To apply to this NOFO, Applicants must register with and submit application materials through ARPA-E eXCHANGE ( https://arpa-e-foa.energy.gov/Registration.aspx ). For detailed guidance on using ARPA-E eXCHANGE, please refer to the ARPA-E eXCHANGE User Guide (https://arpa-e-foa.energy.gov/Manuals.aspx). ARPA-E will not review or consider concept papers submitted through other means. For problems with ARPA-E eXCHANGE, email ExchangeHelp@hq.doe.gov (with NOFO name and number in the subject line). Questions about this NOFO? Check the Frequently Asked Questions available at http://arpa-e.energy.gov/faq . For questions that have not already been answered, email ARPA-E-CO@hq.doe.gov.   AGENCY OVERVIEW The Advanced Research Projects Agency – Energy (ARPA-E), an organization within the Department of Energy (DOE), is chartered by Congress in the America COMPETES Act of 2007 (P.L. 110-69), as amended by the America COMPETES Reauthorization Act of 2010 (P.L. 111-358), as further amended by the Energy Act of 2020 (P.L. 116-260): “(A) to enhance the economic and energy security of the United States through the development of energy technologies that— (i) reduce imports of energy from foreign sources; (ii) reduce energy-related emissions, including greenhouse gases; (iii) improve the energy efficiency of all economic sectors; (iv) provide transformative solutions to improve the management, clean-up, and disposal of radioactive waste and spent nuclear fuel; and (v) improve the resilience, reliability, and security of infrastructure to produce, deliver, and store energy; and (B) to ensure that the United States maintains a technological lead in developing and deploying advanced energy technologies.” ARPA-E issues this Notice of Funding Opportunity (NOFO) under its authorizing statute codified at 42 U.S.C. § 16538. The NOFO and any cooperative agreements or grants made under this NOFO are subject to 2 C.F.R. Part 200 as supplemented by 2 C.F.R. Part 910. ARPA-E funds research on, and the development of, transformative science and technology solutions to address the energy and environmental missions of the Department. The agency focuses on technologies that can be meaningfully advanced with a modest investment over a defined period of time in order to catalyze the translation from scientific discovery to early-stage technology. For the latest news and information about ARPA-E, its programs and the research projects currently supported, see: http://arpa-e.energy.gov/. ARPA-E funds transformational research. Existing energy technologies generally progress on established “learning curves” where refinements to a technology and the economies of scale that accrue as manufacturing and distribution develop drive improvements to the cost/performance metric in a gradual fashion. This continual improvement of a technology is important to its increased commercial deployment and is appropriately the focus of the private sector or the applied technology offices within DOE. In contrast, ARPA-E supports transformative research that has the potential to create fundamentally new learning curves. ARPA-E technology projects typically start with cost/performance estimates well above the level of an incumbent technology. Given the high risk inherent in these projects, many will fail to progress, but some may succeed in generating a new learning curve with a projected cost/performance metric that is significantly better than that of the incumbent technology. ARPA-E will provide support at the highest funding level only for submissions with significant technology risk, aggressive timetables, and careful management and mitigation of the associated risks. ARPA-E funds technology with the potential to be disruptive in the marketplace. The mere creation of a new learning curve does not ensure market penetration. Rather, the ultimate value of a technology is determined by the marketplace, and impactful technologies ultimately become disruptive – that is, they are widely adopted and displace existing technologies from the marketplace or create entirely new markets. ARPA-E understands that definitive proof of market disruption takes time, particularly for energy technologies. Therefore, ARPA-E funds the development of technologies that, if technically successful, have clear disruptive potential, e.g., by demonstrating capability for manufacturing at competitive cost and deployment at scale. ARPA-E funds applied research and development (R&D). The Office of Management and Budget defines “applied research” as an “original investigation undertaken in order to acquire new knowledge…directed primarily towards a specific practical aim or objective” and defines “experimental development” as “creative and systematic work, drawing on knowledge gained from research and practical experience, which is directed at producing new products or processes or improving existing products or processes.”0F1 Applicants interested in receiving financial assistance for basic research (defined by the Office of Management and Budget as “experimental or theoretical work undertaken primarily to acquire new knowledge of the underlying foundations of phenomena and observable facts”)1 should contact the DOE’s Office of Science (http://science.energy.gov/). Office of Science national scientific user facilities (http://science.energy.gov/user-facilities/) are open to all researchers, including ARPA-E Applicants and awardees. These facilities provide advanced tools of modern science including accelerators, colliders, supercomputers, light sources and neutron sources, as well as facilities for studying the nanoworld, the environment, and the atmosphere. Projects focused on early-stage R&D for the improvement of technology along defined roadmaps may be more appropriate for support through the DOE applied energy offices including: the Office of Energy Efficiency and Renewable Energy (http://www.eere.energy.gov/), the Office of Fossil Energy and Carbon Management (https://www.energy.gov/fecm/office-fossil-energy-and-carbon-management), the Office of Nuclear Energy (http://www.energy.gov/ne/office-nuclear-energy), and the Office of Electricity (https://www.energy.gov/oe/office-electricity). ARPA-E encourages submissions stemming from ideas that still require proof-of-concept R&D efforts as well as those for which some proof-of-concept demonstration already exists. Submissions can propose a project with the end deliverable being an extremely creative, but partial solution. PROGRAM OVERVIEW The Seeding Critical Advances for Leading Energy technologies with Untapped Potential (SCALEUP) Ready program provides a vital mechanism for the support of innovative energy R&D that complements ARPA-E’s primary focus on early-stage transformational energy technologies that require proof of concept. Technologies that achieve substantial technical advancement under ARPA-E support may still face significant technical and commercial challenges upon completion of an award's funding period, and thus are at risk of being stranded in their development path once ARPA-E funding ends. Experience across ARPA-E’s diverse energy portfolios, and input from a wide range of investors and industry stakeholders, indicate that pre-commercial scaling projects are critical to establish practical performance and cost parameters. These pre-commercial scaling projects aim to 1) translate the performance achieved at bench scale to commercially scalable versions of the technology, 2) integrate the technology with broader systems, 3) provide extended performance data, and 4) validate the manufacturability and reliability of new energy technologies. Successful scaling projects should enable industry stakeholders to justify the substantial commitments of financial resources, personnel, manufacturing facilities, and materials necessary to subsequently deploy the technologies at a commercial scale. SCALEUP Ready seeks to scale the most promising technologies previously funded by ARPA-E. The possibility of ARPA-E-funded technologies becoming stranded along their development pathways leaves substantial intellectual property developed with American taxpayer dollars vulnerable to adoption by foreign competitors, who capture it for continued development and economic benefit overseas. This harms national competitiveness, as U.S. industries often fall behind on the development, scaling, and manufacturing of technologies necessary to compete in rapidly evolving global energy markets. Thus, projects selected for SCALEUP Ready will meet ARPA-E’s statutory goals by “accelerating transformational technological advances in areas that industry by itself is not likely to undertake because of technical and financial uncertainty."

The objective of this funding opportunity is to support investigator-initiated, phase I clinical trials for diagnostic and therapeutic interventions for heart, lung, blood, and sleep (HLBS) disorders in adults and children. The proposed trial can be single or multisite. Applicants applying for funding under this NOFO should be ready to initiate the clinical trial within the first quarter of the project period. Discussion, submission, and attainment of applicable regulatory (FDA, DSMB, IRB) approvals, and establishment of drug (and placebo, if applicable) supplies, and any necessary third-party agreements should be established by the time of award. If time and support for these and other pre-clinical and/or trial readiness activities are desired, applicants should consider the companion NOFO which utilizes an R61/R33 phased approach.

A.   ELIGIBILITY 1.  Eligible Applicants The following organizations are eligible to apply: ●       Not-for-profit organizations, including think tanks and civil society/non-governmental organizations ●        Public and private educational institutions ●        Public International Organizations and Governmental institutions For-profit entities, even those that may fall into the categories listed above, are not eligible to apply for this NOFO. Organizations may sub-contract with other entities, but only one, non-profit, non-governmental entity can be the prime recipient of the award. When sub-contracting with other entities, the responsibilities of each entity must be clearly defined in the proposal. For more information on the difference between sub-contract and sub-recipient, please refer to 2 CFR 200.331 . 2.  Cost Sharing or Matching Cost sharing or matching is encouraged, but not required for this funding opportunity.  3.  Other Eligibility Requirements All organizations must have a Unique Entity Identifier (UEI) issued via SAM.gov as well as a valid registration in SAM.gov. Please see Section E.3 for more information. Individuals are not required to have a UEI or be registered in SAM.gov. Optional: Applicants are only allowed to submit one proposal per organization. If more than one proposal is submitted from an organization, all proposals from that institution will be considered ineligible for funding under this funding opportunity. 4.    This opportunity will not support: ●       Projects relating to partisan political activity; ●       Charitable or development activities; including direct social services such as medical, psychological, and/or humanitarian support ●       Construction projects; ●       Projects that support specific religious activities; ●       Fund-raising campaigns; ●       Lobbying for specific legislation or programs ●       Scientific research or surveys; ●       Commercial projects; ●       Projects intended primarily for the growth or institutional development of the organization; ●       Projects that duplicate existing projects; ●       Illegal activities B.   PROGRAM DESCRIPTION 1.  Project Background, Goals, and Objectives Algeria presents a significant opportunity for U.S. technological engagement at a pivotal moment. With nearly two-thirds of its population under age 30, the country's shift to English-medium instruction and ambitious University 4.0 initiative create unprecedented openings for American collaboration in the technology sector. As Algeria modernizes its digital infrastructure and educational systems, there is strong interest in partnering with leading technology providers to ensure access to cutting-edge tools and internationally recognized standards. Algeria's next generation of technology leaders—students, educators, entrepreneurs, and community leaders—currently have limited access to training in U.S. artificial intelligence tools, international standards, and best practices in AI governance. Providing access to American AI methodologies and best practices will help ensure that Algerian professionals have diverse options and can make informed choices about the technological ecosystems that best serve their needs and reflect democratic values of transparency, user-centered design, and ethical AI development. This Freedom250 initiative addresses these opportunities by leveraging the five American Spaces across Algeria to deliver practical, hands-on AI training to at least 150 strategic participants who will serve as multipliers within their communities. The program advances U.S. priorities in technological excellence and international partnerships by introducing American AI methodologies in Algeria's technology landscape. Through a modular curriculum spanning AI fundamentals, evaluation frameworks, hands-on labs, and localized application development, participants progress from conceptual understanding to practical proficiency, becoming advocates who can independently apply American frameworks in their professional contexts. This initiative builds directly on Mission Algeria's proven track record in technology and education programming. A 2026 program featuring a Freedom250 AI Envoy engaged Algeria's Ministry of Youth, establishing productive government relationships and demonstrating official interest in U.S. AI collaboration. Additionally, the Mission's 2025 collaboration with the Ministries of Higher Education and Vocational Training—including the country's largest English teaching conference—revealed that 70% of participating teachers expressed greater interest in learning about American AI tools, validating significant demand for practical AI training. The Public Diplomacy Section seeks to implement a transformative program that strengthens U.S.-Algeria partnership in artificial intelligence and emerging technology. At least 150 participants across five cities will complete the program with measurable gains, producing tangible artifacts like prompt libraries and localized AI applications. A cohort of trained local facilitators will later independently deliver the curriculum, enabling the American Spaces to continue programming beyond initial funding and exponentially expand reach. The alumni will serve as advocates for American AI frameworks, with educators integrating U.S. tools into teaching, entrepreneurs building ventures on American platforms, and community leaders promoting informed discourse about ethical technology development using learned frameworks. The ideal implementing partner will demonstrate sustainability-first design through clear training-of-trainers strategies, capacity to deliver quality programming across all five cities, rigorous monitoring and evaluation frameworks, emphasis on practical application over theory, concrete alumni engagement plans, and flexibility to adapt to changing circumstances including virtual delivery. This program represents an important opportunity to strengthen bilateral cooperation. The successful implementer will share the Mission's vision of promoting American technological excellence and ensuring democratic values shape the digital future of the region. Project Audience(s): The primary beneficiaries of this program are the minimum of 150 participants across five Algerian cities who will receive direct training in U.S.-aligned AI tools, standards, and governance frameworks. The program targets university students (ages 18-30) pursuing degrees in technology, engineering, business, and education—a particularly strategic demographic given that nearly two-thirds of Algeria's population is under 30. These young professionals represent the future workforce and are eager to acquire cutting-edge skills that enhance their employability in the global technology marketplace. Educators including teachers, professors, and instructional designers serve as critical multipliers who can integrate American AI tools into their curricula, potentially reaching hundreds of additional students over their careers. They are positioned to normalize U.S. technological frameworks within Algeria's educational system and shape how the next generation understands and applies AI technologies. The program also targets entrepreneurs and small business owners developing technology-based ventures or seeking to integrate AI solutions into existing businesses. This audience is motivated by practical applications that improve efficiency and create competitive advantages. Finally, community leaders and civil society representatives working in non-governmental organizations and youth programs influence public discourse about technology adoption and are positioned to promote ethical AI development and democratic governance frameworks that align with American values. These audiences share key characteristics: they have capacity to train others and are at career stages where exposure to American frameworks can shape long-term professional trajectories. Project Goal:   The goal is to establish the United States as Algeria's preferred partner for artificial intelligence development by embedding American AI tools, standards, and governance frameworks within Algeria's emerging technology ecosystem. This long-term goal envisions a generation of Algerian technology leaders who routinely adopt U.S.-aligned AI methodologies, promote democratic values of transparency and ethical technology development, and serve as multipliers who expand American technological influence throughout Algerian institutions and communities. This goal directly aligns with U.S. foreign policy priorities of advancing American technological leadership globally, promoting democratic governance in digital spaces, and strengthening bilateral partnerships with a strategic partner in North Africa. Project Objectives: ·         Objective 1: Train a minimum of 150 participants across five American Spaces (Algiers, Bechar, Constantine, Oran, and Ouargla) in U.S.-aligned AI tools, standards, and governance frameworks, with at least 80% of participants completing all hands-on labs and collaborative projects by the end of the 12-month program period. ·         Objective 2: Achieve measurable knowledge gains among participants, with pre- and post-program assessments demonstrating at least 30% improvement in understanding of U.S.-aligned AI standards, ethical frameworks, and practical application methodologies ·         Objective 3: Establish a cohort of at least 10 trained local facilitators who can independently deliver the AI curriculum at American Spaces, ensuring program sustainability and enabling continued delivery beyond the initial funding period. ·         Objective 4: Generate tangible outputs demonstrating practical AI proficiency, with participants producing artifacts such as prompt libraries, automated report templates, and localized AI applications that address real challenges in education, health, agriculture, or community service. ·         Objective 5: Create a sustainable community of practice connecting program alumni, facilitators, and American Spaces, with at least 60% of participants remaining engaged through online platforms and contributing to knowledge-sharing activities six months after program completion. 2.  Substantial Involvement N/A READ FULL ANNOUNCEMENT IN THE ATTACHMENTS

Objective: 1. Background The EDCTP Prizes 2026-2027 are recognition prizes funded under Horizon Europe. Prizes are financial contributions given as rewards following the publication of a contest. A ‘recognition prize’ is used to recognise past achievements and outstanding work after it has been performed, whereas an ‘inducement prize’ is used to spur investment in a given direction, by specifying a target prior to the performance of the work. Applications will have to clearly state the involvement of the applicants in the research and innovation activities within the remit of the Global Health EDCTP3 programme. Applicants will have to provide proof of eligibility and a written presentation of the achievements, which will be presented to an independent panel of experts for evaluation. The amounts of the prizes are specified in section 3. They are not linked to the costs incurred by the winner. 2. EDCTP3 Prizes 2026 and related award criteria The prizes will be awarded to the entry that, in the opinion of the independent expert jury, demonstrates having best addressed the cumulative criteria specified under the respective descriptions below. Applications will be graded on a total of…

The Life Sciences Transformational R&D Investment Fund Pilot offers capital grants to support large-scale R&D projects in the UK life sciences sector (eligible projects must exceed £100 million in total costs). It aims to boost research and development within the UK's Life Sciences sector by supporting large-scale investments focused on innovation and strengthening health resilience, as well as projects with the potential to generate economic benefits. This fund complements the separate Life Sciences Innovative Manufacturing Fund (LSIMF).

Objective: 1. Background The EDCTP Prizes 2026-2027 are recognition prizes funded under Horizon Europe. Prizes are financial contributions given as rewards following the publication of a contest. A ‘recognition prize’ is used to recognise past achievements and outstanding work after it has been performed, whereas an ‘inducement prize’ is used to spur investment in a given direction, by specifying a target prior to the performance of the work. Applications will have to clearly state the involvement of the applicants in the research and innovation activities within the remit of the Global Health EDCTP3 programme. Applicants will have to provide proof of eligibility and a written presentation of the achievements, which will be presented to an independent panel of experts for evaluation. The amounts of the prizes are specified in section 3. They are not linked to the costs incurred by the winner. 2. EDCTP3 Prizes 2026 and related award criteria The prizes will be awarded to the entry that, in the opinion of the independent expert jury, demonstrates having best addressed the cumulative criteria specified under the respective descriptions below. Applications will be graded on a total of…

The purpose of this Notice of Funding Opportunity (NOFO) is to leverage NICHD clinical research Network infrastructure relevant to infants, children, women, pregnant and lactating women, and persons with disabilities to conduct innovative, multisite, investigator-initiated clinical trials and observational studies. This NOFO will utilize a bi-phasic (UG3/UH3), milestone-driven mechanism consisting of a start-up phase (UG3) and a full enrollment and clinical trial implementation phase (UH3). Applications submitted in response to this NOFO must address specific aims and milestones for both the UG3 and UH3 phases. A UG3 project (phase I) that meets its milestones will be administratively considered by NICHD and prioritized for transition to the UH3 award (phase II). This NOFO provides an opportunity to leverage NICHD clinical research Network infrastructure as a platform for investigator-initiated innovative hypotheses by any investigator in the extramural community. Applications must be submitted as investigator-initiated, multi-Project Director/Principal Investigator (PD/PI) grant applications in conjunction with the respective NICHD-supported Network Data Coordinating Center (DCC), or equivalent as determined by the NICHD.

The purpose of this NOFO is to enhance the capability of NCATS CTSA Program KL2 scholars and recipients of re-entry supplements supported by the CTSA Program to conduct research as they complete the transition to fully independent academic translational scientists. These R03 grants will support different clinical and translational science research projects, including pilot and feasibility studies; secondary data analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. Research proposed in the R03 application may or may not include patient-oriented research. The R03 is, therefore, intended to support research projects that can be carried out in a short period of time with limited resources and that provide preliminary data to support submission of a subsequent R01, or equivalent, application.

The FAA hereby announces its continuing interest in receiving applications for aviation research grants and cooperative agreements to pursue the long-term growth and short-term technical needs of civil aviation, under this funding opportunity. Eligibility of applicants for the award of an aviation research grant varies depending on the nature of the proposer's organization, as well as the character of the research being proposed. In general, colleges, universities, and other non- profit research institutions under Section 501(c)(3) of Title 26 of United States Code, are eligible to apply for an aviation research grant.   The FAA Aviation Research Grants Program encourages and supports innovative, advanced research of potential benefit to the long-term growth of civil aviation and commercial space transportation. The pursuit of basic and applied research in scientific and engineering disciplines that have the potential to further knowledge and understanding on a broad front of emerging technologies is crucial to the realization of this goal. The intent is to encourage applied research and development to enhance technology assimilation, transfer, and development in the FAA. The FAA Aviation Research Grants Program does not require the immediate application to Research and Development (R&D) programs, although this may occur in some cases. The FAA encourages the submission of proposals that embrace the entire spectrum of physical, chemical, biological, medical, psychological, mathematical, and engineering sciences.   The following list illustrates topics of interest to those who may consider applying for a grant under this funding opportunity:   1.      Capacity and Air Traffic Control Technology 2.      Communications, Navigation, and Surveillance 3.      Aviation Weather 4.      Airports 5.      Aircraft Safety Technology 6.      Human Factors and Aviation Medicine 7.      Systems Science/Operations Research   For more information, please carefully review FAA Notice of Funding Opportunity 20-01, and any supporting attachments.

Through this Notice of Funding Opportunity, the National Cancer Institute (NCI) seeks research projects that implement early phase (Phase 0, I, and II) investigator-initiated clinical trials focused on cancer-targeted diagnostic and therapeutic interventions of direct relevance to the research mission of DCTD and OHAM. The proposed project must involve at least 1 clinical trial related to the scientific interests of one or more of the following research programs: Cancer Therapy Evaluation Program, Cancer Imaging Program, Cancer Diagnosis Program, Radiation Research Program, Complementary and Alternative Medicine Program and/or the HIV and AIDS Malignancies Research Programs. Applicants may propose to conduct an early phase trial by itself, or in combination with another research aim(s) as appropriate.

The U.S. Department of State’s Embassy Bridgetown announces an open competition to implement a two-year EducationUSA Regional Advising Program based in Barbados to expand access to U.S. higher education opportunities across the Eastern Caribbean through comprehensive virtual and in-person advising services. The part-time adviser will deliver monthly webinar series targeting prospective students, virtual outreach programs providing individual and cohort advising for students and parents, and partnership development with at least 15 U.S. universities and regional institutions. The adviser will also assist in developing social media strategies on the Eastern Caribbean EducationUSA page and support key activities including college fairs and educational events. Project Goals and Objectives Expand access to U.S. higher education for Eastern Caribbean youth by establishing comprehensive, professional regional advising services that strengthen people-to-people ties and advance democratic values throughout the Caribbean. Objective 1: Deliver at least 24 monthly webinars over the two-year program period, reaching a minimum of 1,000 unique participants (prospective students, parents, and educators) with comprehensive information about U.S. higher education pathways, application processes, and financial aid opportunities, with at least 50% of participants reporting increased knowledge and confidence in navigating U.S. college applications. Objective 2: Provide individualized and cohort-based virtual advising services to at least 400 prospective students and their families over two years, resulting in at least 200 students submitting complete applications to U.S. universities and at least 100 students successfully enrolling in U.S. higher education institutions, representing measurable growth beyond the current regional baseline of 1,500 annual students. Objective 3: Establish formal partnerships with at least 15 U.S. universities and regional educational insti

A. STATEMENT OF OBJECTIVES This Funding Opportunity Announcement (FOA) is to award multiple cooperative agreements to accredited United States (U.S.) two- and four-year colleges and universities (Institutions of Higher Education (IHEs)) to receive and administer scholarship and fellowship funding—provided through the University Nuclear Leadership Program (UNLP) and as administered by the Department of Energy, Office of Nuclear Energy (DOE-NE)—on behalf of selected students attending these U.S. IHEs. The selection of students to receive scholarships and fellowships through the program will occur via a separate DOE-NE process. A.1 BACKGROUND AND OBJECTIVES UNLP works to attract qualified nuclear science and engineering students (NS&E) to nuclear energy professions by providing undergraduate level scholarships and graduate level fellowships. The scholarships and fellowships are focused on two-, four-year, and graduate programs in science and engineering disciplines related to nuclear energy such as nuclear engineering, mechanical engineering, electrical engineering, chemistry, health physics, nuclear materials science, radiochemistry, applied nuclear physics, nuclear policy, radiation protection technology, nuclear power technology, nuclear maintenance technology, nuclear engineering technology, computer science, cybersecurity, nuclear safety, nuclear operations, mechanical and electrical maintenance, and radiation protection. NE’s mission is to advance nuclear energy science and technology to meet U.S. energy, environmental, and economic needs. NE has identified the following goals to address challenges in the nuclear energy sector, help realize the potential of advanced technology, and leverage the unique role of the government in spurring innovation: • Keep existing U.S. nuclear reactors operating • Deploy new nuclear reactors • Secure and sustain our nuclear fuel cycle • Expand international nuclear energy cooperation Collectively, all NE-sponsored activities support the Department’s priorities to combat the climate crisis, create clean energy jobs with the free and fair chance to join a union and bargain collectively, and promote equity and environmental justice by delivering innovative clean energy technologies for nuclear energy systems. UNLP supports NE’s Nuclear Energy University Program (NEUP), which enables outstanding, cutting-edge, and innovative research at U.S. IHEs through the following: • Integrating research and development (R&D) at U.S. IHEs, national laboratories, and industry to revitalize nuclear education and support NE’s Programs • Attracting the brightest students to the nuclear professions and supporting the nation’s intellectual capital in science and engineering disciplines • Improving U.S. IHE’s infrastructure for conducting R&D and educating students • Facilitating knowledge transfer to the next generation of workers Educating undergraduate and graduate students in NS&E will: • Support the ongoing need for personnel who can develop and maintain the nation’s nuclear power technology • Enhance the R&D capabilities of U.S. IHEs • Fulfill national demand for highly trained scientists and engineers to work in NS&E areas

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to stimulate translation of scientific discoveries and engineering developments in imaging, data science and/or spectroscopic technologies into methods or tools that address contemporary problems in understanding the fundamental biology, potential risk of development, diagnosis, treatment, and/or disease status for cancer or other disease.

The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.

This Notice of Funding Opportunity (NOFO) invites applications for Diabetes Research Centers (DRCs) that are designed to support and enhance the national research effort in diabetes, its complications, and related endocrine and metabolic diseases. The purpose of this Centers program is to bring together basic and clinical investigators to enhance communication, multidisciplinary collaboration, and effectiveness of ongoing research in Diabetes Research Center topic areas. By providing shared access to specialized technical resources (research cores) and supporting a Pilot and Feasibility Program (P&F), DRCs are intended to create an environment that provides the capability for accomplishments greater than those that would be possible by individual research project grant support alone. New Center programs that bring in diverse perspectives, propose unique scientific themes, or provide innovative resources are encouraged. Emphasis will be placed on Center programs that propose enhanced synergies with other NIDDK-funded programs as well as providing a rich mentoring environment for future diabetes researchers.

This funding opportunity is part of a suite of NOFOs within the NIH HEAL Initiative to support the development of safe, effective, and non-addictive therapeutics to treat pain. The goal is to encourage initial translational efforts that will support a drug discovery program and advance projects to the point where they meet the entry criteria for the Pain Therapeutics Development Program. The scope will therefore be focused on development of assays to support a distinct testing funnel, screening efforts to identify hits, and initial characterization of hits and potential therapeutic agents (including small molecules, biologics, and natural products).

Apply for Arts and Humanities Research Council (AHRC) standard research grant funding to support well-defined collaborative projects across the arts and humanities, in areas covered by our remit. You must be based at a UK research organisation eligible for AHRC funding. There is no limit on the value of the grant, the value specified within the summary page is an example.

Apply for funding to work with overseas researchers in the Unites States (US). Submit a collaborative research grant application within the remit of AHRC and US National Science Foundation, Social, Behavioural and Economic Sciences Directorate (NSF-SBE). You must be based at a UK research organisation eligible for AHRC funding. There is no limit on the value of the grant, the value specified within the summary page is an example.

The purpose of this Notice of Funding Opportunity (NOFO) is to invite Small Research Grant (R21) applications that propose to study the ethical, legal, and social implications (ELSI) of human genetics and genomics. Applications may propose studies using either single or mixed methods. Direct involvement of key stakeholders where appropriate is encouraged. These applications should be for small research projects, such as those that involve single investigators. Of particular interest are projects that propose normative or conceptual analyses, including focused legal, economic, philosophical, anthropological, or historical analyses of new or emerging issues. This mechanism can also be used for the collection of preliminary data and the secondary analysis of existing data.

Through this Disaster NOFO, EDA will award investments in regions experiencing severe economic distress or other economic harm resulting from hurricanes, wildfires, tornadoes, floods, and other natural disasters occurring in calendar years 2023 and 2024. EDA’s goal under this NOFO is to assist communities recovering from a disaster by realizing opportunities to recover and change the economic trajectory of the community for the better. In other words, EDA funding seeks to help communities recover and set them on a path to exceed their previous pre-disaster baseline. EDA seeks projects that are responsive to community needs post-disaster by engaging all aspects of the community, with special focus on private industry partners. This Disaster NOFO provides funding through three pathways: Readiness Path – Standalone non-construction projects designed to increase a community’s readiness to apply for or implement disaster recovery funding from private and public sources including, but not limited to, future EDA NOFOs and the Implementation or Industry Transformation Paths under this NOFO. Projects will fund strategy development, capacity building, and/or predevelopment costs necessary for future recovery projects. Implementation Path – Standalone construction or non-construction projects designed to address the economic challenges faced by a community recovering from a natural disaster and improve economic trajectories beyond pre-disaster economic conditions. Industry Transformation Path – Led by a coalition of regional stakeholders, a portfolio of large-scale, multicomponent construction and non-construction projects designed to fundamentally transform the economic trajectory of a region through the development or acceleration of an industry.

Awarded activities will facilitate the translation of novel recording and modulation technologies that can be used to treat and/or diagnose central nervous system (CNS) diseases and disorders and to better understand the human CNS, from proof of concept up to the stage of readiness for first in human (FIH) studies. Technologies may incorporate any signal modality (e.g., electrical, optical, magnetic, acoustic) or a combination thereof. Diverse team-based applications that integrate appropriate domains of expertise are encouraged.

Responding to the needs of the scientific community to bolster a vibrant and sustainable research workforce, the Division of Kidney, Urologic, and Hematologic Diseases (KUH) at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has incorporated additional flexibilities for institutional training programs serving the mission interests of non-malignant kidney, urologic, and hematologic diseases, encompassing both adult and pediatric conditions. The purpose of this notice of funding opportunity is to invite applications for Institutional Network Awards (U2C-TL1) to recruit, train, and retain the next generation of researchers and provide them with the coordinated support, resources, and networks they need to succeed and lead. To maximize integration and promote a highly connected trainee community, institutions are invited to submit a single, unified U2C-TL1 application. Representation across all kidney, urologic, and hematologic disciplines is not expected or required. If feasible, applications may include multiple departments within and across institutions. It is expected that each U2C-TL1 award will actively participate in the Kidney, Urology and Hematology Research-Training Network (KUHR-TN), a nationwide coalition of individual U2C-TL1 awards.

Apply for funding to work with overseas researchers in the State of São Paulo, Brazil. Submit a collaborative research grant application within the remit of Arts and Humanities Research Council (AHRC) and State of São Paulo Research Foundation (FAPESP). You must be based at a UK research organisation eligible for AHRC funding. There is no limit on the value of the grant, the value specified within the summary page is an example.

Apply for funding to work with overseas researchers in Luxembourg. Submit a collaborative research grant application within the remit of Arts and Humanities Research Council (AHRC) and Fonds National de la Recherche (FNR). You must be based at a UK research organisation eligible for AHRC funding. There is no limit on the value of the grant, the value specified within the summary page is an example.

The Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program aims to promote broad participation in the biomedical research ecosystem by supporting resource limited organizations to conduct research, enhance the research environment, and increase sponsored programs administration capacity.This program intends to support eligible, domestic organizations with limited research resources and few biomedical doctoral students.

Apply for funding to pursue an adventurous, ambitious, curiosity-driven project in environmental research. You must be: • based at a UK research organisation eligible for Natural Environment Research Council (NERC) funding • in a role that meets the individual eligibility requirements There is no limit on the value of the grant, the value specified within the summary page is an example.

This cooperative agreement is intended to enhance the capacity and capabilities of state human and animal food testing laboratories in support of an integrated food safety system (IFSS). This is achieved through prioritized sample testing and food defense preparedness in the areas of microbiology, chemistry, and radiochemistry, as well as method development and capacity/capability development projects that support and expand food safety and food defense testing.

The purpose of this Notice of Funding Opportunity (NOFO) is to advance the development of novel informatics and data science approaches that can help individuals understand and improve their health through actionable insights. NLM seeks applications that further the science of personal health informatics by providing meaningful and actionable insights to individuals through innovative personal health data collection, integration, analysis, and personalized risk assessments and interpretation. Applications seeking to advance the understanding of how informatics tools, systems, and platforms can best present the results, interpretation, and limitations of personalized assessments for the benefit of individuals are encouraged. Applications should include end user engaged approaches and real-world evaluation to inform the design of generalizable, reusable, and scalable personal health informatics tools, systems, and platforms for the benefit of individuals in understanding and improving their health.

The goal of this Notice of Funding Opportunity (NOFO) is to provide funding support for the pre-clinical and early stage clinical (Phase I) development of novel small-molecule and biologic drug candidates that prevent Alzheimer's disease (AD), slow its progression, or treat its cognitive and behavioral symptoms. Participants in this program will receive funding for therapy development activities such as medicinal chemistry; pharmacokinetics (PK); Absorption, Distribution, Metabolism, Excretion, Toxicology (ADMET); efficacy in animal models; development of biomarkers for target engagement; formulation development; chemical synthesis under Good Manufacturing Practices (GMP); Investigational New Drug (IND) enabling studies; and initial Phase I clinical testing. Applications not responsive to this NOFO include research on basic mechanisms of disease or mechanisms of drug action; development ofrisk, diagnostic, prognostic, predictive, and preventionbiomarkers, devices, non-pharmacological interventions (e.g., exercise, diet, cognitive training), repurposed drugs and combination therapies; discovery activities such as high-throughput screening and hit optimization; and stand-alone clinical trials.

The Fishing Safety Research Grant Program established by The Coast Guard Authorization Act of 2010 (P.L. 111-281), as amended by the Howard Coble Coast Guard and Maritime Transportation Act of 2014 (P.L. 113-281), is intended to provide funding to individuals in academia, members of non-profit organizations and businesses involved in fishing and maritime matters, and other persons with expertise in commercial fishing safety. The funding will be used to support research on improving the occupational safety of workers in the commercial fishing industry. This includes: improving vessel design; developing and improving emergency and survival equipment; enhancing vessel monitoring systems; improving communication devices, de-icing technology, and severe weather detection. In order to support and administer the grant program, the Coast Guard and NIOSH signed a Memorandum of Understanding on May 17, 2018. While the Coast Guard, along with the Occupational Safety and Health Administration (OSHA), provides regulatory oversight for safety and health matters within the commercial fishing industry, NIOSH is an agency operating under the Centers for Disease Control and Prevention (CDC) with the mission of generating new knowledge in occupational safety and health and transferring that knowledge into practice to prevent worker injury, illness and death. NIOSH conducts and funds scientific research, develops methods to prevent occupational hazards, develops guidance and authoritative recommendations, translates scientific knowledge into products and services, disseminates information, identifies factors underlying work-related disease and injury and responds to requests for workplace health hazard evaluations. NIOSH has an extensive history of conducting research to understand and to reduce hazards in the commercial fishing industry. This research has largely been conducted in close collaboration with crews, industry and the US Coast Guard. To learn more about NIOSH’s work in commercial fishing safety and health, visit https://www.cdc.gov/niosh/topics/fishing/default.html. Research objectives supported by NIOSH include, but are not limited to, the following: identification and investigation of the relationships between hazardous working conditions and associated occupational injuries and fatalities; development of more sensitive means of evaluating hazards at work sites; development of methods for measuring early markers of injuries and fatalities; development of new protective equipment and engineering control technology to reduce work-related injuries and fatalities; development of work practices that reduce the risks of occupational hazards; and evaluation of the technical feasibility or application of a new or improved occupational safety procedure, method, technique, or system, including assessment of economic and other factors that influence their diffusion and successful adoption in workplaces.

This Notice of Funding Opportunity (NOFO) invites applications that propose to use mouse models to conduct rigorous preclinical testing of drugs or drug combinations currently used for other conditions, as well as investigational drugs at various stages of clinical development, predicted to be efficacious in AD/ADRD. This initiative will also support preclinical testing of repurposable or investigational drug candidates in combination with non-pharmacologic interventions leading to robust translational outcomes. The central goal is to establish robust proof of concept that will enable rational drug repurposing and combination therapy development for the treatment and prevention of AD/ADRD.

The goal of the training grant program is to enhance the quality and availability of safety training for United States commercial fishermen. Availability includes the frequency, geographic considerations, channels or partners of dissemination, culturally and/or educational appropriate training material, and other characteristics of a successful training program. As a result, the Coast Guard and NIOSH invite applications to support the development and implementation of training and education programs that: develop and deliver training which addresses the needs of commercial fishermen in the United States provide qualified marine safety instructors, or otherwise accepted by the National Maritime Center instructors and faculty to conduct the training evaluate the effectiveness and impact of the training program on reducing injuries among fishermen coordinate with existing training programs and partnerships with industry fishermen, and agencies conform to 46 U.S.C. § 4502 (i) Safety Standards for commercial fishing safety training In order to support and administer the grant program, the Coast Guard and NIOSH signed a Memorandum of Understanding on May 17, 2018. While the Coast Guard, along with the Occupational Safety and Health Administration (OSHA), provides regulatory oversight for safety and health matters within the commercial fishing industry, NIOSH is an agency operating under the Centers for Disease Control and Prevention (CDC) with the mission of generating new knowledge in occupational safety and health and transferring that knowledge into practice to prevent worker injury, illness and death. NIOSH conducts and funds scientific research, develops methods to prevent occupational hazards, develops guidance and authoritative recommendations, translates scientific knowledge into products and services, disseminates information, identifies factors underlying work-related disease and injury and responds to requests for workplace health hazard evaluations.

This funding opportunity announcement (FOA) encourages research grant applications to develop in vitro and/or ex vivo assays and conduct iterative screening efforts to identify and characterize potential therapeutic agents for neurological or neuromuscular disorders. This FOA is part of a suite of Innovation Grants to Nurture Initial Translational Efforts (IGNITE) to advance projects to the point where they can meet the entry criteria for the Blueprint Neurotherapeutics Network (BPN) or other translational programs.

The CTSA Collaborative and Innovative Acceleration Award (CCIA) aims to accelerate the pace of translational research by supporting the collaborative development, dissemination, and sustainable implementation of innovative solutions across the CTSA Program Consortium and beyond. This Notice of Funding Opportunity (NOFO) invites investigator-initiated applications to develop, demonstrate, and disseminate innovative new approaches, technologies, resources, or models that increase the impact of research across diseases, transform the field of translational science, and bring more treatments for all people more quickly.

This Notice of Funding Opportunity (NOFO) is issued by the Food and Drug Administration (FDA), Center for Veterinary Medicine (CVM), and solicits Research Project (R01) grant applications from institutions or organizations that propose to develop or support the development of designated new animal drugs intended for minor uses in major species or for use in minor species (MUMS).  The FDA is authorized to provide grants to assist in defraying the costs of qualified safety and effectiveness testing that could be used to satisfy the requirements for FDA approval of MUMS-designated drugs. Only entities developing drugs for veterinary use or parties working as research partners with such entities are eligible for grants. The organization (or applicant) seeking approval of the new animal drug under investigation must have opened an Investigational New Animal Drug (INAD) file with FDA/CVM and must hold a minor use or minor species "designation" granted by FDA/CVM's Office of Minor Use and Minor Species Animal Drug Development (OMUMS) for that drug for a specified intended use, in accordance with the provisions of section 573 of the Food, Drug and Cosmetic Act (21 U.S.C. 360ccc-2) and 21 CFR part 516. FDA/CVM's Office of New Animal Drug Evaluation (ONADE) must have reviewed and concurred with the proposed study protocol before an applicant can submit a grant application.

This funding opportunity announcement (FOA) encourages the development and validation of animal models and human/animal tissue ex vivo systems that recapitulate the phenotypic and physiologic characteristics of a defined neurological or neuromuscular disorder. The goal of this FOA is to promote a significant improvement in the translational relevance of animal models or ex vivo systems that will be utilized to facilitate future development of neurotherapeutics. Ideally, models proposed for this FOA would have the potential to provide feasible and meaningful assessments of efficacy following therapeutic intervention that would be applicable in both preclinical and clinical settings. This FOA is part of a suite of Innovation Grants to Nurture Initial Translational Efforts (IGNITE) Program focused on enabling the exploratory and early stages of drug discovery.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) seeks research project (R01) grant applications describing projects that integrate imaging and fluid-based tumor monitoring (liquid biopsy) assays during cancer therapy in patients to determine the optimal use of those modalities in the characterization of therapy response and/or emergence of resistance.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NCI R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this Notice of Funding Opportunity (NOFO) will support creative educational activities with a primary focus on Research Experiences. Applications are encouraged that propose innovative, state-of-the-art programs that address the cause, diagnosis, prevention, or treatment of cancer, rehabilitation from cancer, or the continuing care of cancer patients and the families of cancer patients.

The purpose of this Notice of Funding Opportunity (NOFO) is to invite research grant applications (R01) for the development and use of current and emerging molecular imaging methods to gain fundamental insights into cancer inflammation in vivo. The motivation for this initiative is that much of current imaging research into the role of inflammation in cancer is largely based on in vitro and ex vivo methods with limited utilization of imaging approaches that could lead to significant new insights relevant to dynamic cancer and inflammation interactions. Utilization of molecular imaging probes in pre-clinical and clinical investigations for precise temporal resolution at the molecular and cellular level are valuable approaches for identification and characterization of in vivo inflammatory cellular physiology in cancers and of molecular changes in response to treatment. This FOA encourages applications that focus on developing integrated imaging approaches to interrogate the role of inflammation in cancer through strong cross-field collaboration between cancer basic science researchers and imaging scientists. These collaborations are expected to advance science and understanding of cancer inflammation interactions.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NCI R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this Notice of Funding Opportunity (NOFO) will support creative educational activities with a primary focus on Courses for Skills Development. Applications are encouraged that propose innovative, state-of-the-art programs that address the cause, diagnosis, prevention, or treatment of cancer, rehabilitation from cancer, or the continuing care of cancer patients and the families of cancer patients.

The purpose of this initiative is to support the development of innovative research centers to foster nursing-led programs that promote community-partnered research to address persistent health challenges. Center applications developed in response to this RFA should propose strategies to strengthen the research infrastructure by establishing or expanding centralized research resources in School or College of Nursing (SON/CON), developing and enhancing nurse-led interdisciplinary teams, and building expertise in community-partnered research through conducting pilot research that applies NINR's research lenses. Center strategies should be informed by NINRs mission and should meaningfully engage the community throughout all activities.

This Funding Opportunity Announcement (FOA) is intended to provide an avenue for basic scientists, clinicians and clinical scientists to jointly initiate and conduct translational research projects which translate basic research findings into clinical tools for better human health. The scope of this FOA includes a range of activities to encourage translation of basic research findings which will impact the diagnosis, treatment and prevention of communication disorders. Connection to the clinical condition must be clearly established and the outcomes of the grant must have practical clinical impact.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to stimulate efforts to translate scientific discoveries and engineering developments into methods or tools that address problems in basic research to understand disease, or in applied research to assess risk, detect, prevent, diagnose, treat, and/or manage disease. The rationale is to deliver new capabilities to meet evolving requirements for technologies and methods relevant to the advance of research and delivery of care in pre-clinical, clinical and non-clinical settings, domestic or foreign, for conditions and diseases within the missions of participating institutes.

The National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), invites grant applications for Training Project Grants (TPGs) that are focused on occupational safety and health training. NIOSH is mandated to provide an adequate supply of qualified personnel to carry out the purposes of the Occupational Safety and Health Act, and the TPGs are one of the principal means for meeting this mandate. The majority of TPGs are in academic institutions that provide high quality undergraduate, graduate, and post graduate academic training in a variety of occupational safety and health (OSH) and allied disciplines. NIOSH also funds a limited number of non-academic TPGs to provide specialized training for target audiences and build or strengthen the Nation's OSH workforce capacity.

The goal of this program is to support collaborative translational research projects aligned with NIH efforts to enhance the translation of basic biological discoveries into clinical applications that improve health. It encourages high quality science demonstrating the potential to result in understanding an important disease process or lead to new therapeutic interventions, diagnostics, or prevention strategies within the research interests and priorities of the participating NIH Institutes/Centers (ICs).Specifically, the program seeks to broaden and strengthen translational research collaborations between basic and clinical researchers both within and outside NIH to accelerate and enhance translational science by promoting partnerships between NIH intramural investigators (e.g., those conducting research within the labs and clinics of the NIH) and extramural investigators (e.g., those conducting research in labs outside the NIH), and by providing support for extramural investigators to take advantage of the unique research opportunities available at the NIH Clinical Center by conducting clinical research projects in collaboration with NIH intramural investigators.

The purpose of this Notice of Funding Opportunity (NOFO) is to encourage UG3/UH3 phased cooperative agreement research applications to plan and implement behavioral and social intervention clinical trials. Studies appropriate for this announcement include clinical trials to develop and test behavior change interventions related to dental, oral, or craniofacial conditions. Awards made under this FOA will initially support a milestone-driven planning phase (UG3) for up to 2 years, with possible transition to a clinical trial implementation phase (UH3) of up to five years. Only UG3 projects that have met the scientific milestones and feasibility requirements may transition to the UH3 phase. The UG3/UH3 application must be submitted as a single application, following the instructions described in this FOA. The UG3 phase will permit both scientific and operational planning activities. Scientific planning activities include small-scale data collection to assess the feasibility and/or acceptability of a planned behavioral or social intervention and associated study procedures (e.g., acceptability of study content or mode of delivery; feasibility of proposed data collection procedures; preliminary testing of intervention training and fidelity monitoring procedures). Operational planning activities include, at a minimum, development of: the final clinical protocol; the intervention manual or equivalent; the data management system and other tools for data and quality management, safety and operational oversight plans; recruitment and retention strategies; and other essential documents. The UH3 phase will support the conduct of investigator-initiated intervention research at all stages, from early mechanistic research and intervention development (e.g., Stages 0/ I) through implementation and cost-effectiveness research (Stages IV/V).

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for support of investigator-initiated studies addressing mechanisms by which bariatric surgery impacts cancer risk, and seeks to draw in talented scientists who study bariatric surgery to investigate its effects on cancer, rather than shorter-term outcomes such as weight loss and diabetes.

AHRC awards to support researchers without prior experience of leading a significant research project to accelerate their trajectory as independent researchers, to unlock their potential and build leadership and convenor experience. You must be based at a UK research organisation eligible for AHRC funding. There is no limit on the value of the grant, the value specified within the summary page is an example.

The purpose of this Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions is to support small scale research grants at institutions that do not receive substantial funding from the NIH, with an emphasis on providing biomedical research experiences primarily for undergraduate students and enhancing the research environment at applicant institutions. Eligible institutions must award baccalaureate science degrees and have received no more than $6 million dollars per year of NIH support (in both direct and F and A/indirect costs) in 4 of the last 7 fiscal years. For institutions composed of multiple schools and colleges, the $6 million funding limit is based on the amount of NIH funding received by all the non-health professional schools and colleges within the institution as a whole. This Notice of Funding Opportunity (NOFO) supports investigator-initiated mechanistic and/or minimal risk clinical trials addressing the mission and research interests of the participating NIH institutes. For the purpose of this NOFO, minimal risk clinical trials are defined as those that do not require FDA oversight, do not intend to formally establish efficacy, and have low risks to potentially cause physical or psychological harm.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NIDA R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. This NOFO is intended to support research education activities that enhance the knowledge of substance use and substance use disorder research. The program is intended for those in clinically focused careers and/or those training for careers as clinicians/health service providers, clinical researchers, or optimally a combination of the two. This mechanism may not be used to support non-research-related clinical training.

The purpose of the Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools is to stimulate basic and clinical research in educational institutions that provide baccalaureate or advanced degrees for a significant number of the Nation's research scientists, but that have not been major recipients of NIH support. REAP grants create opportunities for scientists and institutions otherwise unlikely to participate extensively in NIH research programs to contribute to the Nation's biomedical and behavioral research effort. REAP grants are intended to support small-scale research projects proposed by faculty members of eligible, domestic institutions, to expose undergraduate and/or graduate students at health professional schools or graduate schools to meritorious research projects, and to strengthen the research environment of the applicant institution.Eligible institutions must award NIH-relevant baccalaureate or advanced degrees in health professions and have received less than $6 million per year of NIH support (total costs) in 4 of the last 7 fiscal years. In this NOFO, a college is a stand-alone entity and not a component of a university system.

This Notice of Funding Opportunity Announcement (NOFO) invites R25 applications to support the development and implementation of research education programs for recent baccalaureates from all backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences. It is essential to expand and broaden the skilled Alzheimers Disease (AD) and Alzheimers Disease and Related Dementias (ADRD) research workforce and provide exposure to AD/ADRD research to individuals early in their careers. The proposed research education programs will support intensive research experiences in the AD/ADRD field with the goal of preparing recent baccalaureates to transition into strong, research-focused advanced degree programs or competitive private sector research careers in AD-related disciplines.

The goal of the NHLBI Catalyze Program is to provide a comprehensive suite of support and services to facilitate the transition of basic science discoveries into viable diagnostic and therapeutic candidates that have been cleared for human testing, and to develop translational researchers fluent in product development and entrepreneurship. This specific Catalyze Enabling Technologies and Transformative Platforms initiative will support needed to rigorously validate transformative, multi-use platforms or technologies that can enable. Well-suited applications must offer the potential to significantly accelerate and/or transform the areas of early detection and screening, model development, clinical diagnosis, treatment, control, behavior, prevention or epidemiology. Proposed platforms and technologies may have widespread applicability but must be able to improve the outlook for HLBS-related diseases and disorders.

The People and Research Scheme offers grants for activities that help people understand and champion the historic environment through, engagement, skills, training, education and heritage project-based posts. It also offers grants for research activities related to the historic environment sector including scientific and technical conservation, surveys and investigations, publication, archiving, toolkits and guidance. https://historicengland.org.uk/advice/grants/what-we-fund/people-activities/ https://historicengland.org.uk/advice/grants/what-we-fund/research-activities/

NLM wishes to accelerate access to, and availability of, secure, complete datasets and computational models that can serve as the basis for transformative biomedical discoveries. Innovative at-scale computational approaches that increase the speed and scope of curation processes are needed for data mining and knowledge discovery from growing quantities of biomedical data being produced from ongoing data science advances.

This notice of funding opportunity (NOFO) will support research towards understanding and mitigating the deleterious effects of acute exposure to Ultra-Potent Synthetic (UPS) opioids (e.g., fentanyl, carfentanil, nitazenes) and their combinations (fentanyl and xylazine). This NOFO will also support research on the persistent and/or delayed pathophysiological effects after acute exposure to such agents.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to support educational activities that help recruit individuals with specific specialty or disciplinary backgrounds to research careers in biomedical, behavioral and clinical sciences.

The National Library of Medicine (NLM) seeks applications for research projects that drive groundbreaking innovation and advanced development in the fields of bioinformatics, translational bioinformatics, and computational biology. The primary goal of this initiative is to support the creation and implementation of cutting-edge methods, tools, and approaches that can transform the landscape of biomedical data science. This NOFO aims to address the growing need to leverage transformative technologies — such as artificial intelligence (AI), machine learning, and large-scale computational platforms — to extract actionable knowledge from vast, diverse, and complex biological datasets. By enabling more effective interpretation and integration of multi-dimensional biological and biomedical data, this research will ultimately contribute to improving individual and population health outcomes.

The National Library of Medicine (NLM) seeks applications for innovative research in clinical informatics. The overarching goal of this forthcoming program is to catalyze the development and advancement of novel informatics methodologies that empower clinicians, patients, and the broader public to better understand, manage, and improve health and health care delivery. This NOFO will support research focused on the design, implementation, and evaluation of clinical informatics tools and methods that enable data-driven discovery, promote evidence-based decision-making, and support personalized and precision health care. Emphasis will be placed on domain-independent, scalable, and reusable/reproducible approaches for the discovery, analysis, organization, and management of health-related digital objects—including electronic health records (EHRs), clinical notes, imaging data, and patient-generated data. The aim is to transform raw and heterogeneous health data into actionable knowledge, to develop innovative tools, and to implement practical applications that can be generalized across multiple clinical settings and populations. Projects should demonstrate the potential to accelerate scientific insights, improve clinical workflows, and ultimately lead to improved health outcomes.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on: Courses for Skills Development

This notice of funding opportunity (NOFO) encourages innovative research to develop, improve, characterize, and preserve animal models as well as animal model related biological materials, technologies, and new approach methodologies (NAMs) for studies relevant to human health and disease. This NOFO also seeks projects aimed at improving the diagnosis and control of diseases that could confound or interfere with animal use in biomedical research. The proposed project must have broad applicability to multiple NIH Institutes or Centers (ICs) to align with the NIH-wide mission of the Office of Research Infrastructure Programs (ORIP). The proposed studies must include animal models and explore multiple body systems or multiple categories of diseases. Applications that develop models focused on a specific disease or area of research, or only propose studies primarily relevant to a single NIH IC, will be considered not acceptable to this NOFO and will be withdrawn.

This Notice of Funding Opportunity (NOFO) invites R25 applications to support the development and implementation of summer research education programs for high school students, undergraduates, or science teachers from all backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences. It is essential to expand and broaden the skilled Alzheimer's Disease (AD) and Alzheimers Disease Related Dementias (ADRD) research workforce and provide exposure to AD/ADRD research to individuals early in their careers. The proposed research education programs will support intensive summer research experiences in the AD/ADRD field with the goal of exposing participants to AD/ADRD research and encourage further study or participation in biomedical and behavioral research. This NOFO does not allow participants to lead an independent clinical trial, but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor.

Reissue of RFA-20-351.The purpose of this Notice of Funding Opportunity (NOFO) is to encourage applications to pursue invasive neural recording studies focused on mental health-relevant questions. Invasive neural recordings provide an unparalleled window into the human brain to explore the neural circuitry and neural dynamics underlying complex moods, emotions, cognitive functions, and behaviors with high spatial and temporal resolution. Additionally, the ability to stimulate, via the same electrodes, allows for direct causal tests by modulating network dynamics. This funding opportunity aims to target a gap in the scientific knowledge of neural circuit function related to mental health disorders. Researchers should target specific questions suited to invasive recording modalities that have high translational potential. Development of new technologies and therapies are outside the scope of this NOFO.

The purpose of this Notice of Funding Announcement (NOFO) is to encourage pilot research that is not an immediate precursor to testing a service intervention but is consistent with NIMH priorities for services research. While NIMH now requires use of an experimental therapeutics model for all intervention studies, there is recognition that some mission-relevant areas of services research do not involve clinical trials.

This FOA encourages research relevant to the development of novel screening approaches and/or therapeutic interventions for potentially fatal or disabling conditions that have been identified through newborn screening, as well as for "high priority" genetic conditions where screening may be possible in the near future.Having an accurate screening test, as well as demonstrating the benefits of early intervention or treatment, are important criteria for including a condition on a newborn screening panel. This FOA defines a "high priority" condition as one where screening is not currently recommended, but infants with the condition would significantly benefit from early identification and treatment.

The National Center for Medical Rehabilitation Research (NCMRR) Early Career Research (ECR) Award (R03) is intended to support both basic and clinical research from rehabilitation scientists who are establishing independent research careers. The research must be focused on one or more of the areas within the mission of NCMRR: Applicants are encouraged to refer to the NIH Research Plan on Rehabilitation for strategic priorities (https://www.nichd.nih.gov/newsroom/news/110121-NIH-rehab-plan). The NCMRR ECR Award R03 grant mechanism supports various types of projects including secondary analysis of existing data; small, self-contained research projects; development of research methodology; translational research; outcomes research; and development of new technology. Irrespective of the type of project, the intent of the NCMRR ECR Award R03 is for the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) to obtain sufficient preliminary data for a subsequent R01 application.

The purpose of the NIAID Career Transition Award program is to assist postdoctoral fellows' transition to positions of assistant professor or equivalent and initiate a successful biomedical career as an independent research scientist.

The National Institute on Drug Abuse (NIDA) Cutting-Edge Basic Research Award (CEBRA) is designed to foster highly innovative or conceptually creative research related to the etiology, pathophysiology, prevention, or treatment of substance use disorders (SUDs). It supports high-risk and potentially high-impact research that is sparse or not included in NIDA's current portfolio that has the potential to transform SUD research. The proposed research should: 1. develop, and/or adapt, revolutionary techniques or methods for addiction research or that show promising future applicability to SUD research; and /or 2. test an innovative and significant hypothesis for which there are scant precedent or preliminary data and which, if confirmed, would transform current thinking.

This Notice of Funding Opportunity Announcement (NOFO) is designed to encourage and facilitate the entry of investigators to the area of brain imaging research. This NOFO will support both newly independent investigators and established investigators who are seeking to develop and adopt neuroimaging tools and methodologies in their research programs and conduct small "proof-of-concept" studies relevant to substance use disorders and addiction. This NOFO is intended to support Small Research Grant (R03) projects that can be carried out in a short period of time with limited resources.

The NEI supports large-scale clinical vision research projects, including randomized clinical trials and epidemiologic studies on eye/vision conditions. At the time of submission, applications requesting support for these activities are expected to provide detailed information regarding the study rationale, design, analytic methods, protocols and procedures, facilities and environment, organizational structure, and collaborative arrangements. This information is best conveyed in a study protocol and Manual of Procedures (MOP), the development of which represents a costly and time-consuming activity. This clinical research planning grant funding opportunity supports applicants in their planning efforts to conduct collaborative clinical research. The grant may be used to support the development of a study protocol and MOP, as well as to conduct preliminary studies to refine study procedures or document recruitment potential. The grant must not be used to generate data on the effects of a proposed intervention. This NEI NOFO is applicable to both epidemiologic and clinical trial research studies.

Flexible awards to fund fundamental research that leads to new research agendas, networking activity and idea generation, which enables the development of further research opportunities and new research agendas. There is no limit on the value of the grant, the value specified within the summary page is an example.

Data science is an important cross-cutting research approach in the 2022 - 2026 NIDA Strategic Plan and increasing the capacity of experts in addiction related data science is critical. The purpose of this Notice is to facilitate the entry of investigators to the area of addiction-related data science, including newly independent data scientists or established investigators seeking to incorporate novel and cutting-edge data science methodologies into their research programs for the first time. Through this opportunity, investigators will propose to apply emerging data science methods to answer critical questions requiring advanced data analytic strategies. Projects should be small in scale and answer specific research questions or provide preliminary data for a larger scale project. Applicants are encouraged to use existing datasets, follow FAIR principles, and, when applicable, attend to ethical concerns in the conduct of research involving human subjects. Ultimately, the aim is to expedite the development of robust research programs focused on the convergence of innovative data science techniques and addiction research, with initial projects serving as precursors for subsequent, more expansive research projects.

The SuRE program supports research capacity building at eligible higher education institutions through funding investigator-initiated biomedical research inbasic, social, clinical, behavioral, or translational science that falls in the mission areas of the NIH. The purpose of SuRE-First awards is to provide support for investigator-initiated research at resource-limited institutions by full-time faculty who have not had any prior independent, peer-reviewed, external research grants, to furnish students with high-quality undergraduate and/or graduate research experiences, and to enhance the institutional scientific research culture.

The SuRE program supports research capacity building at eligible higher education institutions by funding investigator-initiated biomedical research inbasic, social, clinical, behavioral, or translational science that falls in the mission areas of the NIH. The purpose of SuRE awards is to provide support for investigator-initiated research at resource-limited institutions by full-time faculty who are not currently funded by any NIH Research Project Grants (RPGs) with the exception of SuRE or SuRE-First awards, to furnish students with high-quality undergraduate and/or graduate research experiences, and to enhance the institutional scientific research culture.

The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to elucidate a role for understudied proteins in rare disease. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s). A list of eligible proteins is provided and are members of druggable protein families that have a known association with a rare disease. This NOFO is intended to jumpstart research on understudied proteins that are associated with rare diseases and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins within the context of rare disease.

This announcement supports Executive Order 14276, Restoring America’s Seafood Competitiveness, by soliciting projects that support: workforce development for marine-related professions in marine science, aquaculture/mariculture, and maritime operations; enhancing seafood safety and management through training in seafood best practices, marketing, and fishery management; technological innovation in fishing practices; outreach and education for consumers on quality and sustainability of wild caught fish or products farmed through aquaculture/mariculture; enhanced regionally-specific management of fishery resources based on local knowledge; and strengthening the seafood supply chain through partnerships with industry, researchers, and community organizations to build relationships that increase the sustainability and competitiveness of the marine community in Alaska. Proposed projects must be conducted in Alaska. 

Awards will be made as cooperative agreements to accredited Minority Serving Institutions (MSIs) partnered with non-profit organizations in the United States that are eligible to apply for this NASA Research Announcement (NRA). The period of performance for an award is up to 2 years. Prospective proposers are requested to submit any questions in writing to NASAMUSIC@nasaprs.com no later than 10 business days before the proposal due date so that NASA will have sufficient time to respond. Proposers to this NRA are required to have the following, no later than the due date: 1) a Data Universal Numbering System (DUNS) number, 2) a valid registration with the System for Award Management (SAM) [formerly known as the Central Contractor Registry (CCR)], 3) a valid Commercial And Government Entity (CAGE) Code, 4) a valid registration with NASA Solicitation and Proposal Integrated Review and Evaluation System (NSPIRES) (this also applies to any entities proposed for sub-awards or subcontracts.) Consult Appendix H Section H.3.1 for more eligibility information. Consult Appendix H Section 2.2 regarding teaming requirements and partnership guidelines. The goal of NASA MUSIC is: to provide strategic effort that will leverage research and contract relationships of MSIs and NASA through relationships developed by non-profit organizations that may include collaboration of subject matter experts and access to NASA research facilities; An effort to improve STEM education and research at MSIs; A funded activity that seeks to build institutional capacity of MSIs; An activity to support long-term sustainability of STEM research at MSIs. MUSIC seeks to address the agency goals and objectives through: Increasing the institutional awareness of NASA competitive resources that can build the capacity of MSIs to offer and conduct STEM undergraduate and graduate research with a focus on NASA opportunities. Assembling MSIs and their stakeholders with common interests, and challenges then provide common tools for MSIs to increase efficiency and optimize resources including opportunities to develop formal and informal partnerships. Connecting MSI administrators and university STEM leaders to cutting-edge initiatives at NASA that can increase interest in securing research and contracting opportunities while supporting NASA’s policy to achieve an Agency-wide goal of providing one percent of total contract value of prime and subcontracting awards to MSIs. https://www.hq.nasa.gov/office/procurement/regs/1826.htm To achieve these goals, MUSIC seeks to increase university program capacity about practical uses of research to drive institution sustainability through the following targets: Advance the understanding of MSIs on how to effectively develop institutional administrative support by competing at the university level for funding opportunities, which will result in successful application to, and management of these funding opportunities (including those at NASA). Extend MSI’s capabilities by: A. Leveraging the MSIs research capabilities with NASA research to develop Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) projects that develop and demonstrate innovative technologies that fulfill NASA needs and have significant potential for successful commercialization. B. Increasing the preparation of undergraduate and graduate science, technology, engineering, and mathematics faculty with opportunities to participate with NASA researchers and missions through grants and contracts. To achieve these goals and objectives, NASA solicits proposals from MSIs to implement the NASA MUSIC; to engage MSIs in authentic STEM experiences related to NASA missions; and to inspire and captivate learners utilizing NASA’s unique assets to develop a keen interest in STEM. Every institution that intends to submit a proposal to this NRA, including the proposed prime award or any partner whether an education institution, other non-profit institutions, and other organizations that will serve as sub-awardees or contractors, must be registered in NSPIRES. Electronic submission of proposals is required by the due date and must be submitted by an authorized official of the proposing organization. Such registration must identify the authorized organizational representative(s) who will submit the electronic proposal. All principal investigators and other participants (e.g. co-investigators) must be registered in NSPIRES regardless of submission system. Potential proposers and proposing organizations are urged to access the system(s) well in advance of the proposal due date(s) of interest to familiarize themselves with its structure and enter the requested information. Electronic proposals may be submitted via the NASA proposal data system NSPIRES or via Grants.gov. Organizations that intend to submit proposals via Grants.gov must be registered 1) with Grants.gov and 2) with NSPIRES. Additional programmatic information for this NRA may develop before the proposal due date. If so, such information will be added as a Frequently Asked Question (FAQ) or formal amendment to this NRA and posted on http://nspires.nasaprs.com. It is the proposer’s responsibility to regularly check NSPIRES for updates to this NRA.

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) announces a program that provides NIDDK-supported K01, K08, K23, and K25 recipients the opportunity to apply for Small Grant (R03) support at some point during the latter years of their award period of their K award. Through the use of this mechanism, the NIDDK is seeking to enhance the capability of its K01, K08, K23, and K25 award recipients to conduct research as they complete their transition to fully independent investigator status. The R03 grant mechanism supports different types of projects, including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. The R03 is, therefore, intended to support research projects that can be carried out in a short period of time with limited resources and that may provide preliminary data to support a subsequent R01, or equivalent, application.

UPDATED NOTICE - PLEASE READ: April 6, 2023 EDA is excited to announce the launch of its new grants management platform: the Economic Development Grants Experience (EDGE). EDGE was developed to streamline the application and grants management process by implementing a single platform with increased transparency, improved user experience, higher data quality, and more efficiency throughout the entire grant lifecycle.   As of April 6th, 2023, applications can no longer be submitted on Grants.gov, and will ONLY be accepted through EDGE. To apply in EDGE, please go to: sfgrants.eda.gov . More information on how to apply is provided in the full NOFO.   Please note that the above does not apply for Partnership Planning applications . For more information, please reach out to your point of contact.  Program Description: EDA makes planning and local technical assistance investments to support economic development, foster job creation, and attract private investment in economically distressed areas of the United States. Under the Planning program, EDA makes Partnership Planning, Short-Term Planning, and State Planning awards to eligible recipients to create and implement regional economic development plans designed to build capacity and guide the economic prosperity and resiliency of an area or region. More specifically, EDA makes Partnership Planning investments to designated planning organizations (i.e., District Organizations) serving EDA-designated Economic Development Districts and to Indian Tribes to facilitate the development, implementation, revision, or replacement of Comprehensive Economic Development Strategies (CEDS), which articulate and prioritize the strategic economic goals of recipients’ respective regions. EDA also makes Short-Term and State Planning awards for economic development planning activities that guide the eventual creation and retention of high-quality jobs, particularly for the unemployed and underemployed in the Nation’s most economically distressed regions. Under the Local Technical Assistance program, EDA makes awards to strengthen the capacity of local or State organizations, institutions of higher education, and other eligible entities to undertake and promote effective economic development programs through projects such as feasibility studies, impact analyses, disaster resiliency plans, and project planning. *Please note: While the published Notice of Funding Opportunity (available under "Related Documents") states that the ED900A form and the SF424B form are both required for a complete application, these forms are no longer required and have therefore been removed from the package template.

NOTICE: Application Process as of April 6th EDA is excited to announce the launch of its new grants management platform: the Economic Development Grants Experience (EDGE). EDGE was developed to streamline the application and grants management process by implementing a single platform with increased transparency, improved user experience, higher data quality, and more efficiency throughout the entire grant lifecycle.   As of April 6th, 2023, applications can no longer be submitted on Grants.gov, and will ONLY be accepted through EDGE. To apply in EDGE, please go to: sfgrants.eda.gov. More information on how to apply is provided in the full NOFO.   PARTNERSHIP PLANNING program instructions: Please note that applicants will be invited to submit applications through EDGE for the Partnership Planning program. For more information, please reach out to your EDA point of contact. Program Description: EDA makes planning and local technical assistance investments to support economic development, foster job creation, and attract private investment in economically distressed areas of the United States. Under the Planning program, EDA makes Partnership Planning, Short-Term Planning, and State Planning awards to eligible recipients to create and implement regional economic development plans designed to build capacity and guide the economic prosperity and resiliency of an area or region. More specifically, EDA makes Partnership Planning investments to designated planning organizations (i.e., District Organizations) serving EDA-designated Economic Development Districts and to Indian Tribes to facilitate the development, implementation, revision, or replacement of Comprehensive Economic Development Strategies (CEDS), which articulate and prioritize the strategic economic goals of recipients’ respective regions. EDA also makes Short-Term and State Planning awards for economic development planning activities that guide the eventual creation and retention of high-quality jobs, particularly for the unemployed and underemployed in the Nation’s most economically distressed regions. Under the Local Technical Assistance program, EDA makes awards to strengthen the capacity of local or State organizations, institutions of higher education, and other eligible entities to undertake and promote effective economic development programs through projects such as feasibility studies, impact analyses, disaster resiliency plans, and project planning. *Please note: While the published Notice of Funding Opportunity (available under "Related Documents") states that the ED900A form and the SF424B form are both required for a complete application, these forms are no longer required and have therefore been removed from the package template.

The NICHD Small Research Grant Program (Clinical Trial Required) supports clinical trials that fall within the NICHD mission.

The Cyberinfrastructure for Public Access and Open Science (CI PAOS) program within the Office of Advanced Cyberinfrastructure (OAC) aims to catalyze new and transformative socio-technical partnerships supporting research data infrastructure ecosystems across d omains through early-stage collaborative activities between cyberinfrastructure researchers, scie ntists , research computing experts, data management experts , research labs , university libraries , and other communities of practice. The CI PAOS program supports the NSF Public Access Initiative by encouraging innovation across the CI ecosystem t o address accessibility, discoverability, reliability, reproducibility, sustainability, and utility of data products in alignment with NSF and national goals for public access and open science [ See: NSF Public Access Initiative , Office of Science and Technology Policy Memorandum on Ensuring Free, Immediate, and equitable Access to Federally funded Research , and Desirable Characteristics of Data Repositories for Federally Funded Research ] . CI PAOS builds on previous investments including those through Dear Colleague Letters NSF 19-069 , NSF 20 -068 , NSF 23-018 , and the FAIROS R esearch C oordination N etworks ( RCN ) p rogram solicitation ( NSF 22-553 ) . NSF accepts proposals pursuant to this Program Description year-round. From time to time , NSF may also issue Dear Colleague Letters to encourage proposals on special thema tic interests and opportunities related to this progra m . GUIDANCE TO POTENTIAL PROPOSERS A primary feature of successful CI PAOS projects is a robust, synergistic collaborative team comprising skills from across communities of science/engineering, research data science, and information science discipline(s) and expertise in leveraging connections between cyberinfrastructure researchers and providers and data specialists . Leveraging international collaboration to build shared norms and address c hallenges related to developing and implementing PAOS policies and practices is encouraged . Research and education in science and engineering benefit immensely from international cooperation. P roposals with an international component are also welcome [See: International Collaborations Opportunities at NSF ] . Proposers must target one or more of th e following themes/pathways: Competency Building, Capability Building, and /or Community Building. Competency Building Open s cience /engineering-driven collaboration . A socio -technical collaborative approach in addressing disciplinary , interdisciplinary , domestic, and international data lifecycle challenges is critical to informing and guiding the development of principles, requirements , and standards of a CI ecosystem that fosters pipelines to good data management and pathways to access. Propos al s should clearly describe the goals, challenges, and rationale for the proposed data science and engineering project and include an explanation of the potential for transformative research and broader impacts on the open science ecosystem [ See: U.S. NSF Broader Impacts ] . Successful proposals will also clearly identify utilization science scenarios and use cases . C apability Building Exploratory and pilot activities. <span class="TextRun SCXW92189242 BCX4" lang="EN-US" xml:lang="EN-US" d

UPDATED NOTICE - PLEASE READ: April 6, 2023 EDA is excited to announce the launch of its new grants management platform: the Economic Development Grants Experience (EDGE). EDGE was developed to streamline the application and grants management process by implementing a single platform with increased transparency, improved user experience, higher data quality, and more efficiency throughout the entire grant lifecycle. &nbsp; As of April 6th, 2023, applications can no longer be submitted on Grants.gov, and will ONLY be accepted through EDGE. To apply in EDGE, please go to: sfgrants.eda.gov . More information on how to apply is provided in the full NOFO. &nbsp; PARTNERSHIP PLANNING program instructions: Please note that applicants will be invited to submit applications through EDGE for the Partnership Planning program.&nbsp;For more information, please reach out to your EDA point of contact. Program Description: EDA makes planning and local technical assistance investments to support economic development, foster job creation, and attract private investment in economically distressed areas of the United States. Under the Planning program, EDA makes Partnership Planning, Short-Term Planning, and State Planning awards to eligible recipients to create and implement regional economic development plans designed to build capacity and guide the economic prosperity and resiliency of an area or region. More specifically, EDA makes Partnership Planning investments to designated planning organizations (i.e., District Organizations) serving EDA-designated Economic Development Districts and to Indian Tribes to facilitate the development, implementation, revision, or replacement of Comprehensive Economic Development Strategies (CEDS), which articulate and prioritize the strategic economic goals of recipients’ respective regions. EDA also makes Short-Term and State Planning awards for economic development planning activities that guide the eventual creation and retention of high-quality jobs, particularly for the unemployed and underemployed in the Nation’s most economically distressed regions. Under the Local Technical Assistance program, EDA makes awards to strengthen the capacity of local or State organizations, institutions of higher education, and other eligible entities to undertake and promote effective economic development programs through projects such as feasibility studies, impact analyses, disaster resiliency plans, and project planning. **Please note: While the published Notice of Funding Opportunity (available under "Related Documents") states that the ED900A form and the SF424B form are both required&nbsp;for a complete application, these forms are no longer required and have therefore been removed from the package template.

The NIH Small Research Grant Program supports small research projects that can be carried out in a short period of time with limited resources. This program supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. This Notice of Funding Opportunity does not accept applications proposing clinical trial(s).

UPDATED NOTICE - PLEASE READ: April 6, 2023 EDA is excited to announce the launch of its new grants management platform: the Economic Development Grants Experience (EDGE). EDGE was developed to streamline the application and grants management process by implementing a single platform with increased transparency, improved user experience, higher data quality, and more efficiency throughout the entire grant lifecycle. &nbsp; As of April 6th, 2023, applications can no longer be submitted on Grants.gov, and will ONLY be accepted through EDGE. To apply in EDGE, please go to: sfgrants.eda.gov . More information on how to apply is provided in the full NOFO. &nbsp; PARTNERSHIP PLANNING program instructions: Please note that applicants will be invited to submit applications through EDGE for the Partnership Planning program.&nbsp;For more information, please reach out to your EDA point of contact. Program Description: EDA makes planning and local technical assistance investments to support economic development, foster job creation, and attract private investment in economically distressed areas of the United States. Under the Planning program, EDA makes Partnership Planning, Short-Term Planning, and State Planning awards to eligible recipients to create and implement regional economic development plans designed to build capacity and guide the economic prosperity and resiliency of an area or region. More specifically, EDA makes Partnership Planning investments to designated planning organizations (i.e., District Organizations) serving EDA-designated Economic Development Districts and to Indian Tribes to facilitate the development, implementation, revision, or replacement of Comprehensive Economic Development Strategies (CEDS), which articulate and prioritize the strategic economic goals of recipients’ respective regions. EDA also makes Short-Term and State Planning awards for economic development planning activities that guide the eventual creation and retention of high-quality jobs, particularly for the unemployed and underemployed in the Nation’s most economically distressed regions. Under the Local Technical Assistance program, EDA makes awards to strengthen the capacity of local or State organizations, institutions of higher education, and other eligible entities to undertake and promote effective economic development programs through projects such as feasibility studies, impact analyses, disaster resiliency plans, and project planning. **Please note: While the published Notice of Funding Opportunity (available under "Related Documents") states that the ED900A form and the SF424B form are both required&nbsp;for a complete application, these forms are no longer required and have therefore been removed from the package template.

UPDATED NOTICE - PLEASE READ: April 6, 2023 EDA is excited to announce the launch of its new grants management platform: the Economic Development Grants Experience (EDGE). EDGE was developed to streamline the application and grants management process by implementing a single platform with increased transparency, improved user experience, higher data quality, and more efficiency throughout the entire grant lifecycle. &nbsp; As of April 6th, 2023, applications can no longer be submitted on Grants.gov, and will ONLY be accepted through EDGE. To apply in EDGE, please go to: sfgrants.eda.gov . More information on how to apply is provided in the full NOFO. &nbsp; PARTNERSHIP PLANNING program instructions: Please note that applicants will be invited to submit applications through EDGE for the Partnership Planning program.&nbsp;For more information, please reach out to your EDA point of contact. Program Description: EDA makes planning and local technical assistance investments to support economic development, foster job creation, and attract private investment in economically distressed areas of the United States. Under the Planning program, EDA makes Partnership Planning, Short-Term Planning, and State Planning awards to eligible recipients to create and implement regional economic development plans designed to build capacity and guide the economic prosperity and resiliency of an area or region. More specifically, EDA makes Partnership Planning investments to designated planning organizations (i.e., District Organizations) serving EDA-designated Economic Development Districts and to Indian Tribes to facilitate the development, implementation, revision, or replacement of Comprehensive Economic Development Strategies (CEDS), which articulate and prioritize the strategic economic goals of recipients’ respective regions. EDA also makes Short-Term and State Planning awards for economic development planning activities that guide the eventual creation and retention of high-quality jobs, particularly for the unemployed and underemployed in the Nation’s most economically distressed regions. Under the Local Technical Assistance program, EDA makes awards to strengthen the capacity of local or State organizations, institutions of higher education, and other eligible entities to undertake and promote effective economic development programs through projects such as feasibility studies, impact analyses, disaster resiliency plans, and project planning. **Please note: While the published Notice of Funding Opportunity (available under "Related Documents") states that the ED900A form and the SF424B form are both required&nbsp;for a complete application, these forms are no longer required and have therefore been removed from the package template.

UPDATED NOTICE - PLEASE READ: April 6, 2023 EDA is excited to announce the launch of its new grants management platform: the Economic Development Grants Experience (EDGE). EDGE was developed to streamline the application and grants management process by implementing a single platform with increased transparency, improved user experience, higher data quality, and more efficiency throughout the entire grant lifecycle. &nbsp; As of April 6th, 2023, applications can no longer be submitted on Grants.gov, and will ONLY be accepted through EDGE. To apply in EDGE, please go to: sfgrants.eda.gov. More information on how to apply is provided in the full NOFO. &nbsp; PARTNERSHIP PLANNING program instructions: Please note that applicants will be invited to submit applications through EDGE for the Partnership Planning program.&nbsp;For more information, please reach out to your EDA point of contact. Program Description: EDA makes planning and local technical assistance investments to support economic development, foster job creation, and attract private investment in economically distressed areas of the United States. Under the Planning program, EDA makes Partnership Planning, Short-Term Planning, and State Planning awards to eligible recipients to create and implement regional economic development plans designed to build capacity and guide the economic prosperity and resiliency of an area or region. More specifically, EDA makes Partnership Planning investments to designated planning organizations (i.e., District Organizations) serving EDA-designated Economic Development Districts and to Indian Tribes to facilitate the development, implementation, revision, or replacement of Comprehensive Economic Development Strategies (CEDS), which articulate and prioritize the strategic economic goals of recipients’ respective regions. EDA also makes Short-Term and State Planning awards for economic development planning activities that guide the eventual creation and retention of high-quality jobs, particularly for the unemployed and underemployed in the Nation’s most economically distressed regions. Under the Local Technical Assistance program, EDA makes awards to strengthen the capacity of local or State organizations, institutions of higher education, and other eligible entities to undertake and promote effective economic development programs through projects such as feasibility studies, impact analyses, disaster resiliency plans, and project planning. **Please note: While the published Notice of Funding Opportunity (available under "Related Documents") states that the ED900A form and the SF424B form are both required&nbsp;for a complete application, these forms are no longer required and have therefore been removed from the package template.

The Biomechanics and Mechanobiology (BMMB) program is part of the Mechanics of Materials cluster within the Division of Civil, Mechanical, and Manufacturing Innovation. The BMMB program supports fundamental and transformative research that advances our understanding of engineering biomechanics and/or mechanobiology. The program emphasizes the study of biological mechanics across multiple domains, from sub-cellular to whole organism. Distinct from conventional engineering materials, the program encourages the consideration of diverse living tissues as smart materials that are self-designing. BMMB projects must have a clear biological component, a clear mechanics component, and must improve our understanding of the mechanical behavior of a living system. Investigations of the mechanical behavior of biological molecules, cells, tissues, and living systems are welcome. An important concern is the influence of in vivo mechanical forces on cell and matrix biology in the histomorphogenesis, maintenance, regeneration, repair, and aging of tissues and organs. The program is also interested in efforts to translate recent biomechanical and mechanobiological discoveries into engineering science. Multiscale mechanics approaches are encouraged but not required. Projects may include theoretical, computational, or experimental approaches, or a combination thereof. NSF does not support clinical trials; however, feasibility studies involving human volunteers or animal subjects may be supported if appropriate to the scientific objectives of the project. Proposals should address the novelty and/or potentially transformative nature of the proposed work compared to previous work in the field. Also, it is essential to address why the proposed work is important in terms of engineering science, and to state the potential impact of success in the research on society and/or industry. Innovative proposals outside of these specific areas of biomechanics and mechanobiology will be considered. However, prior to submission of particularly unique topics, it is strongly recommended that Principal Investigators (PIs) contact the program director to discuss how the proposed work fits within the scope of the program and avoid the possibility of the proposal being returned without review. Related programs also fund certain aspects of biomechanics and mechanobiology research, and PIs are encouraged to examine these to find the appropriate program for submission. Proposals with a heavy emphasis on tissue engineering or developing validated models of tissue and organ systems should consider the Engineering of Biomedical Systems (EBMS) program.Projects addressing biological questions about the physiological mechanisms and structural features of organisms should consult the Physiological Mechanisms &amp; Biomechanics (PMB) program.Projects elucidating aspects of neural control may consider the Perception, Action, &amp; Cognition (PAC) program or the Mind, Machine, and Motor Nexus (M3X) program if the project contains work relevant to human-machine interaction. Projects in rehabilitation engineering should consider the Disability and Rehabilitation Engineering (DARE) program. Projects focused on fundamental research related to design, characterization, and modification of biomaterials should consider the Biomaterials (BMAT) program. Manufacturing systems proposals should consider the Advanced Manufacturing (AM) program. Work on the interplay between structure, dynamics, and function of biomolecules without advancing our understanding of the mechanics of a living system should consider the Molecular Biophysics program. Researchers who believe their work may span multiple programs are particularly encouraged to contact the cognizant program directors well in advance of submission. The duration of unsolicited proposal awards is generally up to three years; proposals for a shorter duration are welcome. Single-investigator award budgets typically include support for one graduate student (or equivalent trainee) and up to one month of PI time per year (awards for multiple investigator projects are typically larger). Proposal budgets or durations that are much larger than typical should be discussed with the program director prior to submission. Proposers can view budget amounts and other information from recent awards made by this program via the &ldquo;What Has Been Funded (Recent Awards Made Through This Program, with Abstracts)&rdquo; link towards the bottom of this page.

The objective of this Agreement is to advance historic preservation at the local level by establishing a task agreement between the National Park Service and the National Alliance of Preservation Commissions (NAPC) to provide training opportunities, promote the Federal Certified Local Government program, and strengthen local preservation commissions by providing bi-annual State Certified Local Government Coordinator Training

The Greening Youth Foundation (GYF) for the purpose of hiring four GYF Interns to support the research, programming, and dissemination of knowledge regarding the key African-American figures in National Capital Parks- East.

To provide research, technical assistance, and educational opportunities to partners and the national parks in the National Capital Region and Service wide. Unless otherwise specified herein, the terms and conditions as stated in the CW CESU Agreement will apply to this Task Agreement.

Although the majority living with schizophrenia and related disorders are over 35 years old, including those first diagnosed and those aging with the illness, the mechanisms underlying the generation and trajectory of the illness remain poorly understood. The purpose of this initiative is to advance translational research to better understand the emergence and trajectory of schizophrenia and related disorders in mid to late life, and to identity targets for future development of prevention and treatment efforts.

This Notice of Funding Opportunity (NOFO) encourages research on the biology of high confidence risk factors associated with complex brain disorders, with a focus on the intracellular, transcellular and circuit substrates of neural function. For the purposes of this NOFO, the term complex can refer to a multifactorial contribution to risk (e.g., polygenic and/or environmental) and/or highly distributed functional features of the brain disorder. Studies may be either hypothesis-generating (unbiased discovery) or hypothesis-testing in design and may utilize in vivo, in situ, or in vitro experimental paradigms, e.g., model organisms or human cell-based assays. While behavioral paradigms and outcome measures can be incorporated into the research design to facilitate the characterization of intracellular, transcellular and circuit mechanisms, these are neither required nor expected. Studies should not attempt to model disorders but instead should aim to elucidate the neurobiological impact of individual or combined risk factor(s), such as the affected molecular and cellular components and their relationships within defined biological process(es). This can include the fundamental biology of these factors, components and processes. The resulting paradigms, component pathways and biological processes should be disseminated with sufficient detail to enrich common and/or federated data resources (e.g., those contributing to the Gene Ontology, Synaptic Gene Ontology, FAIR Data Informatics) in order to bridge the gap between disease risk factors, biological mechanism and therapeutic target identification. The present NOFO (R21 activity code) can be used for applications to develop early stage, high-risk, exploratory approaches or establish proof-of-concept where there is little or no preliminary data. Applicants proposing to develop lines of inquiry where feasibility or proof of concept has been established should apply to the companion R01 NOFO (PAR-xx-xxx).

This initiative seeks to solicit applications for research projects that address the link between social disconnection including both objective social isolation as well as perceived social isolation (otherwise known as loneliness) and suicide in late-life. Emphasis is placed on research that identifies neurobiological and environmental mechanisms associated with social isolation and loneliness that increase risk for suicidal thoughts and behavior in late-life, that uses an experimental therapeutics approach to identify targets and develop and test interventions to prevent late-life suicide, and that develops new and modifies existing service delivery models to enhance social connection in late-life to prevent suicide.

The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R34 Clinical Trial Optional mechanism focusing on alcohol health services. This NOFO will broadly focus on closing the treatment gap for individuals with alcohol use disorder (AUD); within this focus, there are five major areas of emphasis: (1) increasing access to treatment for AUD, (2) making treatment for AUD more appealing, (3) examining cost structures and insurance systems, (4) conducting studies on dissemination and implementation of existing evidence-based approaches to treating AUD, and (5) reducing health disparities as a means of addressing the treatment gap in AUD for health disparity populations.

This BAA is for the National Marine Fisheries Service, also known as NOAA Fisheries. The purpose of this notice is to request applications for special projects and programs associated with the NOAA Fisheries strategic plan and mission goals, as well as to provide the general public with information and guidelines on how NOAA will select applications and administer discretionary Federal assistance under this Broad Agency Announcement (BAA). This notice is not a mechanism to fund existing NOAA awards.&nbsp;Each NOAA Line Office that supports financial assistance (National Marine Fisheries Service, National Ocean Service, National Weather Service, Office of Atmospheric Research, Office of Education, and National Environmental Satellite Data Information Service) has a separate BAA found in Grants.gov, so applicants should submit their application to the BAA for the Line Office that best fits their application. A description of NOAA Line Offices is found at https://www.corporateservices.noaa.gov/public/lineoffices.html and https://www.noaa.gov/office-education. Applicants may also contact the Agency Contact below for more information. If you submit the same application to more than Line Office, mention this in your application and notify the relevant contacts so that NOAA may coordinate internally.&nbsp;&nbsp;

This notice is not a mechanism to fund existing NWS awards. The purpose of this notice is to request applications for special projects and programs associated with NWS's strategic plan and mission goals, as well as to provide the general public with information and guidelines on how NWS will select applications and administer discretionary Federal assistance under this Broad Agency Announcement (BAA). Each NOAA Line Office that supports financial assistance (National Marine Fisheries Service, National Ocean Service, National Weather Service, Office of Atmospheric Research, Office of Education, and National Environmental Satellite Data Information Service) has a separate BAA found in Grants.gov, so applicants should submit their proposal to the BAA for the Line Office that best fits their proposal. A description of NOAA Line Offices is found at&nbsp;https://www.corporateservices.noaa.gov/public/lineoffices.html and&nbsp;&nbsp;&nbsp;https://www.noaa.gov/office-education and applicants may contact the Agency Contacts in Section VII. below for more information. If you submit the same proposal to more than Line Office, mention this in your proposal and notify the relevant contacts in Section VII. so that NOAA may coordinate internally.&nbsp;&nbsp;

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications to support the validation of molecular/cellular/imaging markers (referred to as "markers" or "biomarkers") and assays for cancer detection, diagnosis, prognosis, monitoring, and prediction of response or resistance to treatment, as well as markers for cancer prevention and control. This FOA will support investigator-initiated research for both analytical, and clinical validation of assays to be used in cancer treatment, control, or prevention trials supported by the NCI. This NOFO will also support the validation of pharmacodynamic markers and markers of toxicity. Applicants should have assays that work on human samples and whose importance is well justified for development into clinical assays. As chemotherapies and/or radiation therapies are increasingly combined with immunotherapies to enhance the durability of anti-cancer responses, assays for measuring multiple markers, including immune markers, can be developed and validated simultaneously. The UH2 phase of this NOFO supports analytical validation of assays for these molecular/cellular/imaging markers, which must be achieved within 2 years before assays may undergo clinical validation. The UH3 phase of this NOFO supports clinical validation of analytically validated assays for up to 3 years using well-annotated biospecimens from retrospective or prospective clinical trials or studies. This NOFO may be used to validate existing assays for use in other cancer clinical trials, observational studies, or population studies. Efforts to harmonize clinical laboratory tests, including investigation into the performance and reproducibility of assays across multiple clinical laboratories, are also appropriate for this funding opportunity. Projects proposed for this NOFO will require multi-disciplinary collaboration among scientific investigators, oncologists, statisticians, and clinical laboratory scientist.

Through this Notice of Funding Opportunity (NOFO) is to accelerate the pace of translation of NCI-supported methods/assays/technologies (referred to as "assays") to the clinic. Specifically, the focus of this NOFO is on the adaption and clinical validation of molecular/cellular/imaging markers (referred to as "markers" r "biomarkers") for cancer detection, diagnosis, prognosis, monitoring, and prediction of response in treatment, as well as markers for cancer control and prevention. Research applications may support the acquisition of well-annotated specimens from NCI-supported or other clinical trials or observational cohorts/consortia for the purpose of clinical validation of the assay. Research projects proposed for this NOFO encourage multi-disciplinary interaction among scientific investigators, assay developers, clinicians, statisticians, and clinical laboratory staff. Clinical laboratory scientist(s) and statistical experts are highly encouraged to comprise integral parts of the application. This NOFO is not intended to support early-stage development of technology or the conduct of clinical trials, but rather the adaption and validation of assays to the point where they could be integrated into clinical trials as investigational assays/tools/devices.

Expected Outcome: Objectives and profile of the ERC Advanced Grant Principal Investigator The objective of the Advanced Grant is to support excellent Principal Investigators that are established research leaders. An ERC Advanced Grant Principal Investigator is expected to be an active researcher with a track record of significant research achievements. Size of ERC Advanced Grants Advanced Grants may be awarded up to a maximum of EUR 2 500 000 for a period of 5 years . The maximum amount of the grants is reduced pro rata temporis for projects of a shorter duration. Additional funding up to EUR 1 000 000 * can be requested to cover further eligible costs (e.g. start-up costs, major equipment, access to large facilities, major experimental and field work costs) when these are necessary to carry out the proposed work. The requests for additional funding must be duly justified in the proposal. Additional funding is not subject to pro rata temporis reduction for projects of shorter duration. * Except for Principal Investigators in Starting, Consolidator, or Advanced Grant re-locating to the EU or an Associated Country from elsewhere to take up their ERC grant. In this case, the maximum…

This initiative seeks to solicit applications for research projects that address the link between social disconnection including both objective social isolation as well as perceived social isolation (otherwise known as loneliness) and suicide in late-life. Emphasis is placed on research that identifies neurobiological and environmental mechanisms associated with social isolation and loneliness that increase risk for suicidal thoughts and behavior in late-life, that uses an experimental therapeutics approach to identify targets and develop and test interventions to prevent late-life suicide, and that develops new and modifies existing service delivery models to enhance social connection in late-life to prevent suicide.

The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R34 Clinical Trial Optional mechanism focusing on alcohol health services. This NOFO will broadly focus on closing the treatment gap for individuals with alcohol use disorder (AUD); within this focus, there are five major areas of emphasis: (1) increasing access to treatment for AUD, (2) making treatment for AUD more appealing, (3) examining cost structures and insurance systems, (4) conducting studies on dissemination and implementation of existing evidence-based approaches to treating AUD, and (5) reducing health disparities as a means of addressing the treatment gap in AUD for health disparity populations.

This Notice of Funding Opportunity (NOFO) encourages research on the biology of high-confidence risk factors associated with complex brain disorders, with a focus on the intracellular, transcellular, and circuit substrates of neural function. For the purposes of this NOFO, the term complex can refer to a multifactorial contribution to risk (e.g., polygenic and/or environmental) and/or highly distributed functional features of the brain disorder. Studies may be either hypothesis-generating (unbiased discovery) or hypothesis-testing in design and may utilize in vivo, in situ or in vitro experimental paradigms, e.g., model organisms or human cell-based assays. While behavioral paradigms and outcome measures can be incorporated into the research design to facilitate the characterization of intracellular, transcellular, and circuit mechanisms, these are neither required nor expected. Studies should not attempt to model disorders but instead should aim to elucidate the neurobiological impact of individual or combined risk factor(s), such as the affected molecular and cellular components and their relationships within defined biological process(es). This can include the fundamental biology of these factors, components, and processes. The resulting paradigms, component pathways, and biological processes should be disseminated with sufficient detail to enrich common and/or federated data resources (e.g., those contributing to the Gene Ontology, Synaptic Gene Ontology, FAIR Data Informatics) in order to bridge the gap between disease risk factors, biological mechanism and therapeutic target identification. The present NOFO (R01 activity code) can be used for applications to further develop lines of inquiry where feasibility or proof-of-concept has been established. Applicants proposing exploratory research at the early and conceptual stages of project development should apply to the companion R21 NOFO PAR-24-025

This Funding Opportunity Announcement (FOA) encourages grant applications for Biomedical Technology Resource Centers (BTRCs). BTRCs are national resource centers for conducting research and development on new technologies that are driven by the needs of basic, translational, and/or clinical researchers. BTRCs also make their technologies available to other investigators, train members of the research community in the use of the technologies, and disseminate the technologies broadly.

Although the majority living with schizophrenia and related disorders are over 35 years old, including those first diagnosed and those aging with the illness, the mechanisms underlying the generation and trajectory of the illness remain poorly understood. The purpose of this initiative is to advance translational research to better understand the emergence and trajectory of schizophrenia and related disorders in mid to late life, and to identity targets for future development of prevention and treatment efforts.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for identification of small molecules that function to elucidate the biology of disease as chemical probes or function as agonists or antagonists of disease target(s) for therapy or immunotherapy. The NOFO is intended to support discovery research for the identification of validated hits relevant to health-related outcomes of participating NIH Institutes. Stages of discovery research covered by this NOFO include: 1) assay development for specific biological targets and disease mechanisms relevant to the mission of participating NIH Institutes with the intent to screen for small molecule compounds that show potential as probes for use in advancing knowledge about the known targets, identifying new targets, or as pre-therapeutic leads; 2) screen implementation high throughput target-focused approaches or moderate throughput phenotypic- and fragment-based approaches to identify initial screening hits; 3) hit validation, including implementation of secondary assays that are orthogonal to the primary assay, advanced cheminformatics analysis and initial medicinal chemistry inspection to prioritize the hit set, and follow-up assays to characterize mode and mechanism of action of the validated hits; 4) hit-to-lead optimization, including SAR to optimize target engagement, selectivity and to minimize chemical liabilities, ADME, PK and PD studies, and, if appropriate, in vivo modeling to test efficacy or biological effects.

The goal of this Funding Opportunity Announcement (FOA) is to encourage applications for studies that will enhance knowledge of mechanisms associated with neuropsychiatric symptoms (NPS) in persons with Alzheimer's disease (AD) or Alzheimer's disease-related dementias (ADRD). The findings are expected to advance mechanistic understanding of both biobehavioral and neurobiological pathways leading to NPS. Findings may also provide insight into novel therapeutic targets that can be advanced into interventions to treat and prevent the development of NPS in AD and/or ADRD

The goal of this NOFO is to support doctoral candidates from a variety of academic disciplines for up to two years for the completion of the doctoral dissertation research project. Research projects should align with NIDA funding priorities detailed here (https://www.drugabuse.gov/funding/funding-priorities). This award will facilitate the entry of promising new investigators into the field of substance use/substance use disorder (SU(D) research, enhancing the pool of highly talented SU(D) researchers.

The Blueprint Neurotherapeutics Network (BPN) invites applications from neuroscience investigators seeking support to advance their small molecule drug discovery and development projects into the clinic. Participants in the BPN are responsible for conducting all studies that involve disease- or target-specific assays, models, and other research tools and receive funding for all activities to be conducted in their own laboratories. In addition, applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in medicinal chemistry, pharmacokinetics, toxicology, formulations development, chemical synthesis including under Good Manufacturing Practices (GMP), and Phase I clinical testing. Projects can enter either at the Discovery stage, to optimize promising hit compounds through medicinal chemistry to the Development stage, to advance a single development candidate through Investigational New Drug (IND)-enabling toxicology studies and phase I clinical testing. Alternatively, projects can enter at the Development stage and progress in a shorter period to IND enabling toxicology studies and phase I clinical testing. BPN awardee Institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN contractors (and thereby control the patent prosecution and licensing negotiations) for drug candidates developed in this program.