Grants ($50K–$500K) in US

The U.S. Fish and Wildlife Service (Service) requests interested entities to submit research, restoration, and Regional Project proposals for the restoration of the Great Lakes Basin fish and wildlife resources, as authorized under the Great Lakes Fish and Wildlife Restoration Act (16U.S.C. 941c). The purpose of the Great Lakes Fish and Wildlife Restoration Act (GLFWRA) is to provide assistance to States, Indian Tribes, and other interested entities to encourage cooperative conservation, restoration, research, and management of the fish and wildlife resources and their habitats in the Great Lakes Basin. Supported in part by the Great Lakes Restoration Initiative, we expect approximately $3.5 million to support proposals this fiscal year. Available funding and proposal awards are subject to final Congressional appropriations for Fiscal Year 2026. Up to 33 and one-third percent of the total Congressional appropriation to the GLFWRA is eligible to fund Regional Project proposals. Expected award funding for Regional Project proposals is between $200,000 to $500,000. Successful restoration and research proposals have ranged from $2,000 to $500,000 with the average proposal at $217,843. Expected award funding for restoration and research proposals is between $10,000 and $250,000. Selected restoration and research proposals and Regional Project proposals will be awarded funding for the duration of the proposal via a grant or cooperative agreement between the recipient and the Service. Funding will be made available once the official award letter has been received by the successful applicant and the performance period has started. Continuation of proposals funded in previous fiscal years are eligible but will be considered and reviewed as a new proposal. Restoration and research proposals will be awarded a grant agreement and Regional Project proposals will be awarded a cooperative agreement under this announcement. Cooperative Ecosystem Studies Units (CESU) Network partners that submit Regional Project proposals that qualify as CESU proposals will be subject to the CESU indirect cost rate cap. Regional Projects are authorized activities of the Service related to fish and wildlife resource protection, restoration, maintenance, and enhancement impacting the resources of multiple States or Indian Tribes with fish and wildlife management authority in the Great Lakes Basin. The two-page restoration and research pre-proposals and Regional Project proposals are submitted to the Service to determine eligibility and the Proposal Review Committee (PRC) scores and ranks the proposals using GLFWRA Review Criteria (Review Criteria). Successful restoration and research pre-proposal applicants are invited to submit full proposals, which are scored and ranked by the PRC using the Review Criteria. The PRC recommends the restoration and research full proposals and Regional Project proposals for funding to the Service"s Midwest Region 3 Regional Director for approval. Successful restoration and research and Regional Project proposal applicants can anticipate receiving an official grant or cooperative agreement award letter between January and March 2027.

The NAWCA U.S. Small Grants Program goal is to promote partnerships between public agencies and groups interested in:Protecting, improving, restoring, and managing an appropriate distribution and a variety of wetland ecosystems and other habitats for wetland-associated migratory birds and other fish and wildlife in the U.S.;Maintaining and improving the current distribution of wetlands-associated migratory bird populations; andMaintaining an abundance of waterfowl (ducks, geese, and swans) and other populations of wetlands-associated migratory birds consistent with the objectives of the North American Waterfowl Management Plan, U.S. Shorebird Conservation Plan, Partners in Flight Bird Conservation Plan, and state related plans.The program requires a 1:1 non-federal match. Research projects are not considered an allowable project activity. This program supports the Department of Interior and U.S. Fish and Wildlife Service's mission of protecting and managing the nation's natural resources by collaborating with partners and stakeholders to conserve land and water and to expand outdoor recreation and access.The grant program for wetlands conservation and management is administered by the U.S. Fish and Wildlife Service's Division of Bird Habitat Conservation. Thirteen partner organizations make up the North American Wetlands Conservation (NAWC) Council and participate in the review and assessment of proposals. For a full list of Council members, visit: https://www.fws.gov/partner/north-american-wetlands-conservation-council. Also, for U.S. Small scoring criteria, refer to instructions (page 23) included with this notice of funding opportunity.To view previously successful awarded NAWCA U.S. Small Projects, visit NAWCA's external facing database to query for your viewing: https://www.fws.gov/grantsum/

The U.S. Embassy Kuala Lumpur Public Diplomacy Section seeks proposals that advance American leadership, prosperity, and security interests in Malaysia. This program supports initiatives that promote U.S. technological innovation and economic competitiveness, showcase American excellence in sports and education, strengthen ties with exchange program alumni, and position the United States as Malaysia's most trusted international partner.   Priority areas include: advancing U.S. leadership in artificial intelligence and emerging technologies; leveraging major sporting events to demonstrate American excellence; engaging alumni networks to amplify U.S. influence; and promoting American English language education and pathways to U.S. higher education institutions. Programs should demonstrate clear alignment with U.S. national interests, measurable outcomes, and sustainable impact beyond the grant period. Successful proposals will engage influential Malaysian stakeholders, promote American standards, and contribute to making America more prosperous and secure.

NOAA/NMFS is soliciting competitive proposals for grants and cooperative agreements for projects that will support NOAA’s mission for stewardship of living marine resources and the sustainable management of U.S. commercial longline fisheries. Projects will ensure data pipelines are in place to inform the sustainable management of U.S. commercial fisheries that interact with endangered species as they migrate throughout the Pacific — a problem that has led to fishery closures when annual interaction limits are reached. Through these efforts, NOAA will strengthen the competitiveness of U.S. commercial longline fisheries, creating a more level playing field for American fishermen, while reinforcing U.S. leadership in marine resource management. Projects must benefit aggregations of endangered marine turtles that have documented linkages to the Pacific Islands Region (PIR), are impacted by PIR federally managed commercial fisheries, and address NOAA’s Endangered Species Act (ESA) recovery obligations. For the Fiscal Year (FY) 2026 funding competition, we are soliciting projects that: 1) monitor and implement protection measures to conserve western Pacific leatherback sea turtles occurring in the Coral Triangle region (Indonesia, Malaysia, the Philippines, Papua New Guinea, or Solomon Islands); 2) monitor and implement protection measures to conserve North Pacific loggerhead sea turtles in Japan; and 3) progress conservation momentum and build capacity for research, monitoring and protection of endangered marine turtle populations in order to benefit U.S. trust resources that occur in international waters. 

The U.S. Department of State’s Bureau of East Asia and Pacific Affairs (EAP) and U.S. Consulate General Auckland announce an open competition to implement Young Pacific Leaders (YPL) Solutions Labs, a series of workshops centered around the following U.S. foreign policy priorities in the Pacific region: ·        Unlocking Investment in the Pacific ·        Advancing the American Decade of Sports for Pacific Economic Impact ·         Pursuing Peace in the Pacific with Faith Communities ·        Promoting Digital Freedom and Open Information Environments Applicants may apply to host one, more, or all of the YPL workshops in the series with the average cost of one workshop being roughly $100,000 to $250,000. Since 2013, the YPL program has cultivated the target audience and participants of emerging Pacific Island Country (PICs) leaders ages 20-40 into advocates for U.S. policy in a region of increasing strategic importance. Since YPL’s inception YPL alumni have delivered on U.S. priorities across the region. The YPL Solutions Labs will be a series throughout 2026-2028 to catalyze advocacy and action on U.S. priorities. The YPL Solutions Labs will build on past YPL programs that advanced U.S. foreign policy priorities in the Pacific region, namely previous conferences, workshops, exchanges, YPL alumni-led projects, community service activities, and digital engagement.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for projects to expand, improve, or transform the utility of mammalian cancer and tumor models for translational research. With this NOFO, the NCI intends to encourage submission of projects devoted to demonstrating that mammalian models or their derivatives used for translational research are robust representations of human biology, are appropriate to test questions of clinical importance, and provide reliable information for patients' benefit. These practical goals contrast with the goals of many mechanistic, NCI-supported R01 projects that employ mammals, or develop and use mammalian cancer models, transplantation tumor models, or models derived from mammalian or human tissues or cells for hypothesis-testing, non-clinical research. Among many other possible endeavors, applicants in response to this FOA could propose demonstrations of how to overcome translational deficiencies of mammalian oncology models, define new uses of mammalian models or their genetics for unexplored translational challenges, advance standard practices for use of translational models, test approaches to validate and credential models, or challenge current practices for how models are used translationally

This Notice of Funding Opportunity (NOFO) aims to support new biomedical, behavioral, and social science investigators who are in the early stages of establishing independent careers in tobacco regulatory research. The R03 grant mechanism supports different types of projects, including pilot and feasibility studies, secondary analysis of existing data, small, self-contained research projects, development of research methodology, and development of new research technology. Applicants are encouraged to conduct projects that ultimately have the potential to inform regulations on tobacco product manufacturing, distribution, and marketing. Research projects must address one or more High-Priority Research Topic(s) related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP) as mandated by the Family Smoking Prevention and Tobacco Control Act (FSPTCA), Public Law 111-31. The awards under this NOFO will be administered by NIH using funds made available through FDA CTP and the FSPTCA. Research results from this NOFO are expected to generate findings and data directly relevant to informing the FDA's regulation of the manufacture, distribution, and marketing of tobacco products to protect public health.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this NIDCD R25 program is to support educational activities that help recruit individuals with specific specialty or disciplinary backgrounds to research careers in biomedical, behavioral and clinical sciences.

The U.S. Fish and Wildlife Service (Service) Coastal Program provides technical and financial assistance to partners to support projects that protect and restore fish and wildlife habitats on public and private lands in priority coastal ecosystems. This support is provided through cooperative agreements with conservation partners and landowners, including state and Tribal agencies. Coastal Program staff work with partners, stakeholders, and other Service programs in important areas for conservation. They implement regional strategic plans that identify priority species and habitats for conservation in these focus areas.Applicants seeking technical or financial assistance from the Coastal Program are required to contact a local Program office BEFORE developing or submitting an application. You can find this information in the current strategic plan at this link or by contacting your local Coastal Program office at https://www.fws.gov/program/coastal/contact-us.Projects are developed collaboratively by partners and Service field staff. All Coastal Program projects must align with the missions of the U.S. Department of the Interior, the U.S. Fish and Wildlife Service, and the Coastal Program. They are also based on sound biological principles and the best available science.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to encourage individuals who have not had substantial biomedical research experience, or who have the potential to significantly benefit from additional biomedical research experience to pursue further studies or careers in research. To accomplish the stated over-arching goal, this NOFO will support educational activities with a primary focus on: (1) Research Experiences, (2) Curriculum or Methods Development and (3) Outreach. The NCI’s mission is to conduct and support research, training, health information dissemination, and other programs concerning cancer. This funding opportunity seeks to facilitate educational activities that encourage students to become knowledgeable about cancer and available to focus on cancer later in their careers. To promote broad interest in pursuing a career in biomedical research via early intervention strategies, the NCI Youth Enjoy Science (YES) Program will support efforts to create and maintain an institutional program to engage grades 6-12 and/or undergraduate students in cutting edge cancer research experiences. The proposed institutional programs may also provide research experiences for the grade 6-12 teachers and undergraduate faculty members. The goals are to inspire interest in biomedical sciences, help envision research as a career path, and strengthen practical research and career skills. In alignment with these goals, institutions may develop unique programs that capitalize on their research strengths and are responsive to their target populations.

The U.S. Department of State is pleased to announce that funding is available through its Public Diplomacy Small Grants Program , administered by the U.S. Mission to Libya through the Tunis-based U.S. Libya External Office. This Annual Program Statement outlines key strategic priorities and funding opportunities for proposals that advance Libyan-U.S. mutual interests , reinforce regional stability and security , and promote shared prosperity between the United States and Libya.   Proposals should directly support one or more of the following objectives:   o   Promote Economic Opportunity and U.S. Collaboration o   Showcase U.S.-Libyan Partnership and Shared Values o   Support Libya’s Unity, Stability and Security   Projects involving alumni of U.S. Government exchange programs are strongly encouraged. This notice is subject to availability of funding.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to accelerate the adoption and validation of molecular/cellular/imaging markers (referred to as "markers" or "biomarkers") and assays for cancer detection, diagnosis, prognosis, monitoring, and prediction of response or resistance to treatment, as well as markers for cancer prevention and control. This NOFO will also support the validation of pharmacodynamic markers and markers of toxicity. Applicants to this NOFO must have an assay(s) whose performance has been analytically validated in specimens similar to those for the intended clinical use of the marker(s) and assay(s). As chemotherapies and/or radiation therapies are increasingly combined with immunotherapies to enhance the durability of anti-cancer responses, assays for measuring multiple markers, including immune markers, can be developed and validated simultaneously. The UH3 mechanism will support the clinical validation of established assays for up to 3 years using specimens from retrospective or prospective clinical trials or studies. This NOFO may be used to validate existing assays for use in other trials, observational studies, or population studies. Efforts to harmonize clinical laboratory tests, including investigation into the performance and reproducibility of assays across multiple clinical laboratories, are also appropriate for this funding opportunity. Projects proposed for this NOFO will require multi-disciplinary interaction and collaboration among scientific investigators, oncologists, statisticians, and clinical laboratory scientists. This NOFO is not intended to support early-stage development of technology or the conduct of clinical trials but is intended for validation of assays to the point where they could be integrated into clinical trials/studies as investigational assays.

This notice of funding opportunity (NOFO) invites applications for investigator-initiated clinical trials of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions) in NCCIH-designated areas of high research priority. Applications submitted under this NOFO are expected to propose a multisite feasibility clinical trial that will provide new information that is scientifically necessary for the planning and conduct of a subsequent clinical efficacy or effectiveness study, pragmatic trial, or dissemination and implementation trial within NCCIHs mission. NCCIH expects that applications to this NOFO will describe the planned future clinical trial and in so doing demonstrate that the proposed (R01) research is scientifically necessary to design or plan the subsequent fully powered, full-scale clinical trial. Under this R01, the data collected should be used to fill gaps in scientific knowledge, including, but not limited to the following: assessing whether the intervention can be delivered with fidelity across sites; demonstrating feasibility of recruitment, accrual, and randomization of participants across sites; demonstrating participant adherence to the intervention, as well as retention of participants throughout the study across sites; refining and assessing the feasibility of protocolized multimodal interventions, and/or demonstrating feasibility of data collection across sites in preparation for a future fully powered, multisite efficacy or effectiveness trial. The need for multisite feasibility trials is expected to be justified by sufficient preliminary data from previous single site feasibility or acceptability trial(s) or the published literature. The data collected should be used to fill gaps in scientific knowledge and be necessary to develop a competitive fully powered multisite clinical trial that has the potential to make a significant impact on public health.

The purpose of this NOFO is to enhance the capability of NCATS CTSA Program KL2 scholars and recipients of re-entry supplements supported by the CTSA Program to conduct research as they complete the transition to fully independent academic translational scientists. These R03 grants will support different clinical and translational science research projects, including pilot and feasibility studies; secondary data analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. Research proposed in the R03 application may or may not include patient-oriented research. The R03 is, therefore, intended to support research projects that can be carried out in a short period of time with limited resources and that provide preliminary data to support submission of a subsequent R01, or equivalent, application.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for support of investigator-initiated studies addressing mechanisms by which bariatric surgery impacts cancer risk, and seeks to draw in talented scientists who study bariatric surgery to investigate its effects on cancer, rather than shorter-term outcomes such as weight loss and diabetes.

The Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program aims to promote broad participation in the biomedical research ecosystem by supporting resource limited organizations to conduct research, enhance the research environment, and increase sponsored programs administration capacity.This program intends to support eligible, domestic organizations with limited research resources and few biomedical doctoral students.

The purpose of this Notice of Funding Opportunity (NOFO) is to invite research grant applications (R01) for the development and use of current and emerging molecular imaging methods to gain fundamental insights into cancer inflammation in vivo. The motivation for this initiative is that much of current imaging research into the role of inflammation in cancer is largely based on in vitro and ex vivo methods with limited utilization of imaging approaches that could lead to significant new insights relevant to dynamic cancer and inflammation interactions. Utilization of molecular imaging probes in pre-clinical and clinical investigations for precise temporal resolution at the molecular and cellular level are valuable approaches for identification and characterization of in vivo inflammatory cellular physiology in cancers and of molecular changes in response to treatment. This FOA encourages applications that focus on developing integrated imaging approaches to interrogate the role of inflammation in cancer through strong cross-field collaboration between cancer basic science researchers and imaging scientists. These collaborations are expected to advance science and understanding of cancer inflammation interactions.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NCI R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this Notice of Funding Opportunity (NOFO) will support creative educational activities with a primary focus on Courses for Skills Development. Applications are encouraged that propose innovative, state-of-the-art programs that address the cause, diagnosis, prevention, or treatment of cancer, rehabilitation from cancer, or the continuing care of cancer patients and the families of cancer patients.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NIDA R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. This NOFO is intended to support research education activities that enhance the knowledge of substance use and substance use disorder research. The program is intended for those in clinically focused careers and/or those training for careers as clinicians/health service providers, clinical researchers, or optimally a combination of the two. This mechanism may not be used to support non-research-related clinical training.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NCI R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this Notice of Funding Opportunity (NOFO) will support creative educational activities with a primary focus on Research Experiences. Applications are encouraged that propose innovative, state-of-the-art programs that address the cause, diagnosis, prevention, or treatment of cancer, rehabilitation from cancer, or the continuing care of cancer patients and the families of cancer patients.

The purpose of the Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools is to stimulate basic and clinical research in educational institutions that provide baccalaureate or advanced degrees for a significant number of the Nation's research scientists, but that have not been major recipients of NIH support. REAP grants create opportunities for scientists and institutions otherwise unlikely to participate extensively in NIH research programs to contribute to the Nation's biomedical and behavioral research effort. REAP grants are intended to support small-scale research projects proposed by faculty members of eligible, domestic institutions, to expose undergraduate and/or graduate students at health professional schools or graduate schools to meritorious research projects, and to strengthen the research environment of the applicant institution.Eligible institutions must award NIH-relevant baccalaureate or advanced degrees in health professions and have received less than $6 million per year of NIH support (total costs) in 4 of the last 7 fiscal years. In this NOFO, a college is a stand-alone entity and not a component of a university system.

The purpose of this Notice of Funding Opportunity (NOFO) is to invite Small Research Grant (R21) applications that propose to study the ethical, legal, and social implications (ELSI) of human genetics and genomics. Applications may propose studies using either single or mixed methods. Direct involvement of key stakeholders where appropriate is encouraged. These applications should be for small research projects, such as those that involve single investigators. Of particular interest are projects that propose normative or conceptual analyses, including focused legal, economic, philosophical, anthropological, or historical analyses of new or emerging issues. This mechanism can also be used for the collection of preliminary data and the secondary analysis of existing data.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to support educational activities that help recruit individuals with specific specialty or disciplinary backgrounds to research careers in biomedical, behavioral and clinical sciences.

NLM wishes to accelerate access to, and availability of, secure, complete datasets and computational models that can serve as the basis for transformative biomedical discoveries. Innovative at-scale computational approaches that increase the speed and scope of curation processes are needed for data mining and knowledge discovery from growing quantities of biomedical data being produced from ongoing data science advances.

The purpose of this Notice of Funding Opportunity (NOFO) is to advance efforts for a nationally integrated animal food safety system providing state animal food regulatory programs the ability to achieve full implementation of the Animal Food Regulatory Program Standards (AFRPS) within 5 years and to maintain full implementation. This NOFO will also fund optional projects for state animal food regulatory programs to: Advance food safety and protect public health by strengthening partnerships with the FDA and other state animal food regulatory partners through sharing, collaboration, coordination, and leveraging each other’s expertise, work, data, and enforcement actions. Develop and standardize processes, procedures, systems, and other methods to integrate federal and state animal food regulatory work resulting in mutual reliance. Specific outcomes may include, but are not limited to: State animal food regulatory programs will achieve and maintain implementation of the AFRPS, which is recognized as a critical element to creating a national, fully integrated food safety system. Operational use of standardized animal food regulatory systems developed by state programs to compel federal reliance on state regulatory work and resources and reciprocal state reliance on federal work and resources, resulting in mutual reliance. This project will strengthen and improve FDA efforts to build an integrated food safety system by building high quality state animal food regulatory programs that can promote regulatory compliance and prevent foodborne illnesses.

This Funding Opportunity Announcement (FOA) issued by the Food and Drug Administration (FDA), Center for Veterinary Medicine (CVM), builds upon the National Antimicrobial Resistance Monitoring System (NARMS) which was initiated in 1996 as one of the key activities in a national action plan to combat antibiotic resistance threats. The purpose of this FOA is to protect and promote public health by enhancing, strengthening, and sustaining antibiotic resistance surveillance in retail food specimens within the NARMS program. The NARMS cooperative agreement is intended to improve the detection of antibiotic resistance among bacteria in food commodities, as well as expand to new sites to expand the scope of sampling. Measurable outcomes of the program will be in alignment with the NARMS Objectives.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on: Courses for Skills Development

This notice of funding opportunity (NOFO) encourages innovative research to develop, improve, characterize, and preserve animal models as well as animal model related biological materials, technologies, and new approach methodologies (NAMs) for studies relevant to human health and disease. This NOFO also seeks projects aimed at improving the diagnosis and control of diseases that could confound or interfere with animal use in biomedical research. The proposed project must have broad applicability to multiple NIH Institutes or Centers (ICs) to align with the NIH-wide mission of the Office of Research Infrastructure Programs (ORIP). The proposed studies must include animal models and explore multiple body systems or multiple categories of diseases. Applications that develop models focused on a specific disease or area of research, or only propose studies primarily relevant to a single NIH IC, will be considered not acceptable to this NOFO and will be withdrawn.

The National Institute on Drug Abuse (NIDA) Cutting-Edge Basic Research Award (CEBRA) is designed to foster highly innovative or conceptually creative research related to the etiology, pathophysiology, prevention, or treatment of substance use disorders (SUDs). It supports high-risk and potentially high-impact research that is sparse or not included in NIDA's current portfolio that has the potential to transform SUD research. The proposed research should: 1. develop, and/or adapt, revolutionary techniques or methods for addiction research or that show promising future applicability to SUD research; and /or 2. test an innovative and significant hypothesis for which there are scant precedent or preliminary data and which, if confirmed, would transform current thinking.

The purpose of the NIAID Career Transition Award program is to assist postdoctoral fellows' transition to positions of assistant professor or equivalent and initiate a successful biomedical career as an independent research scientist.

The SuRE program supports research capacity building at eligible higher education institutions by funding investigator-initiated biomedical research inbasic, social, clinical, behavioral, or translational science that falls in the mission areas of the NIH. The purpose of SuRE awards is to provide support for investigator-initiated research at resource-limited institutions by full-time faculty who are not currently funded by any NIH Research Project Grants (RPGs) with the exception of SuRE or SuRE-First awards, to furnish students with high-quality undergraduate and/or graduate research experiences, and to enhance the institutional scientific research culture.

The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to elucidate a role for understudied proteins in rare disease. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s). A list of eligible proteins is provided and are members of druggable protein families that have a known association with a rare disease. This NOFO is intended to jumpstart research on understudied proteins that are associated with rare diseases and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins within the context of rare disease.

The SuRE program supports research capacity building at eligible higher education institutions through funding investigator-initiated biomedical research inbasic, social, clinical, behavioral, or translational science that falls in the mission areas of the NIH. The purpose of SuRE-First awards is to provide support for investigator-initiated research at resource-limited institutions by full-time faculty who have not had any prior independent, peer-reviewed, external research grants, to furnish students with high-quality undergraduate and/or graduate research experiences, and to enhance the institutional scientific research culture.

REAP Renewable Energy Systems and Energy Efficiency Improvement Program. Refer to Application Package AND Application Instruction links to obtain all necessary forms for a complete application. Contact State Energy Coordinators with questions: http://www.rd.usda.gov/files/RBS_StateEnergyCoordinators.pdf

Awards will be made as cooperative agreements to accredited Minority Serving Institutions (MSIs) partnered with non-profit organizations in the United States that are eligible to apply for this NASA Research Announcement (NRA). The period of performance for an award is up to 2 years. Prospective proposers are requested to submit any questions in writing to NASAMUSIC@nasaprs.com no later than 10 business days before the proposal due date so that NASA will have sufficient time to respond. Proposers to this NRA are required to have the following, no later than the due date: 1) a Data Universal Numbering System (DUNS) number, 2) a valid registration with the System for Award Management (SAM) [formerly known as the Central Contractor Registry (CCR)], 3) a valid Commercial And Government Entity (CAGE) Code, 4) a valid registration with NASA Solicitation and Proposal Integrated Review and Evaluation System (NSPIRES) (this also applies to any entities proposed for sub-awards or subcontracts.) Consult Appendix H Section H.3.1 for more eligibility information. Consult Appendix H Section 2.2 regarding teaming requirements and partnership guidelines. The goal of NASA MUSIC is: to provide strategic effort that will leverage research and contract relationships of MSIs and NASA through relationships developed by non-profit organizations that may include collaboration of subject matter experts and access to NASA research facilities; An effort to improve STEM education and research at MSIs; A funded activity that seeks to build institutional capacity of MSIs; An activity to support long-term sustainability of STEM research at MSIs. MUSIC seeks to address the agency goals and objectives through: Increasing the institutional awareness of NASA competitive resources that can build the capacity of MSIs to offer and conduct STEM undergraduate and graduate research with a focus on NASA opportunities. Assembling MSIs and their stakeholders with common interests, and challenges then provide common tools for MSIs to increase efficiency and optimize resources including opportunities to develop formal and informal partnerships. Connecting MSI administrators and university STEM leaders to cutting-edge initiatives at NASA that can increase interest in securing research and contracting opportunities while supporting NASA’s policy to achieve an Agency-wide goal of providing one percent of total contract value of prime and subcontracting awards to MSIs. https://www.hq.nasa.gov/office/procurement/regs/1826.htm To achieve these goals, MUSIC seeks to increase university program capacity about practical uses of research to drive institution sustainability through the following targets: Advance the understanding of MSIs on how to effectively develop institutional administrative support by competing at the university level for funding opportunities, which will result in successful application to, and management of these funding opportunities (including those at NASA). Extend MSI’s capabilities by: A. Leveraging the MSIs research capabilities with NASA research to develop Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) projects that develop and demonstrate innovative technologies that fulfill NASA needs and have significant potential for successful commercialization. B. Increasing the preparation of undergraduate and graduate science, technology, engineering, and mathematics faculty with opportunities to participate with NASA researchers and missions through grants and contracts. To achieve these goals and objectives, NASA solicits proposals from MSIs to implement the NASA MUSIC; to engage MSIs in authentic STEM experiences related to NASA missions; and to inspire and captivate learners utilizing NASA’s unique assets to develop a keen interest in STEM. Every institution that intends to submit a proposal to this NRA, including the proposed prime award or any partner whether an education institution, other non-profit institutions, and other organizations that will serve as sub-awardees or contractors, must be registered in NSPIRES. Electronic submission of proposals is required by the due date and must be submitted by an authorized official of the proposing organization. Such registration must identify the authorized organizational representative(s) who will submit the electronic proposal. All principal investigators and other participants (e.g. co-investigators) must be registered in NSPIRES regardless of submission system. Potential proposers and proposing organizations are urged to access the system(s) well in advance of the proposal due date(s) of interest to familiarize themselves with its structure and enter the requested information. Electronic proposals may be submitted via the NASA proposal data system NSPIRES or via Grants.gov. Organizations that intend to submit proposals via Grants.gov must be registered 1) with Grants.gov and 2) with NSPIRES. Additional programmatic information for this NRA may develop before the proposal due date. If so, such information will be added as a Frequently Asked Question (FAQ) or formal amendment to this NRA and posted on http://nspires.nasaprs.com. It is the proposer’s responsibility to regularly check NSPIRES for updates to this NRA.

This announcement supports Executive Order 14276, Restoring America’s Seafood Competitiveness, by soliciting projects that support: workforce development for marine-related professions in marine science, aquaculture/mariculture, and maritime operations; enhancing seafood safety and management through training in seafood best practices, marketing, and fishery management; technological innovation in fishing practices; outreach and education for consumers on quality and sustainability of wild caught fish or products farmed through aquaculture/mariculture; enhanced regionally-specific management of fishery resources based on local knowledge; and strengthening the seafood supply chain through partnerships with industry, researchers, and community organizations to build relationships that increase the sustainability and competitiveness of the marine community in Alaska. Proposed projects must be conducted in Alaska. 

UPDATED NOTICE - PLEASE READ: April 6, 2023 EDA is excited to announce the launch of its new grants management platform: the Economic Development Grants Experience (EDGE). EDGE was developed to streamline the application and grants management process by implementing a single platform with increased transparency, improved user experience, higher data quality, and more efficiency throughout the entire grant lifecycle.   As of April 6th, 2023, applications can no longer be submitted on Grants.gov, and will ONLY be accepted through EDGE. To apply in EDGE, please go to: sfgrants.eda.gov. More information on how to apply is provided in the full NOFO.   PARTNERSHIP PLANNING program instructions: Please note that applicants will be invited to submit applications through EDGE for the Partnership Planning program. For more information, please reach out to your EDA point of contact. Program Description: EDA makes planning and local technical assistance investments to support economic development, foster job creation, and attract private investment in economically distressed areas of the United States. Under the Planning program, EDA makes Partnership Planning, Short-Term Planning, and State Planning awards to eligible recipients to create and implement regional economic development plans designed to build capacity and guide the economic prosperity and resiliency of an area or region. More specifically, EDA makes Partnership Planning investments to designated planning organizations (i.e., District Organizations) serving EDA-designated Economic Development Districts and to Indian Tribes to facilitate the development, implementation, revision, or replacement of Comprehensive Economic Development Strategies (CEDS), which articulate and prioritize the strategic economic goals of recipients’ respective regions. EDA also makes Short-Term and State Planning awards for economic development planning activities that guide the eventual creation and retention of high-quality jobs, particularly for the unemployed and underemployed in the Nation’s most economically distressed regions. Under the Local Technical Assistance program, EDA makes awards to strengthen the capacity of local or State organizations, institutions of higher education, and other eligible entities to undertake and promote effective economic development programs through projects such as feasibility studies, impact analyses, disaster resiliency plans, and project planning. **Please note: While the published Notice of Funding Opportunity (available under "Related Documents") states that the ED900A form and the SF424B form are both required for a complete application, these forms are no longer required and have therefore been removed from the package template.

The Biomechanics and Mechanobiology (BMMB) program is part of the Mechanics of Materials cluster within the Division of Civil, Mechanical, and Manufacturing Innovation. The BMMB program supports fundamental and transformative research that advances our understanding of engineering biomechanics and/or mechanobiology. The program emphasizes the study of biological mechanics across multiple domains, from sub-cellular to whole organism. Distinct from conventional engineering materials, the program encourages the consideration of diverse living tissues as smart materials that are self-designing. BMMB projects must have a clear biological component, a clear mechanics component, and must improve our understanding of the mechanical behavior of a living system. Investigations of the mechanical behavior of biological molecules, cells, tissues, and living systems are welcome. An important concern is the influence of in vivo mechanical forces on cell and matrix biology in the histomorphogenesis, maintenance, regeneration, repair, and aging of tissues and organs. The program is also interested in efforts to translate recent biomechanical and mechanobiological discoveries into engineering science. Multiscale mechanics approaches are encouraged but not required. Projects may include theoretical, computational, or experimental approaches, or a combination thereof. NSF does not support clinical trials; however, feasibility studies involving human volunteers or animal subjects may be supported if appropriate to the scientific objectives of the project. Proposals should address the novelty and/or potentially transformative nature of the proposed work compared to previous work in the field. Also, it is essential to address why the proposed work is important in terms of engineering science, and to state the potential impact of success in the research on society and/or industry. Innovative proposals outside of these specific areas of biomechanics and mechanobiology will be considered. However, prior to submission of particularly unique topics, it is strongly recommended that Principal Investigators (PIs) contact the program director to discuss how the proposed work fits within the scope of the program and avoid the possibility of the proposal being returned without review. Related programs also fund certain aspects of biomechanics and mechanobiology research, and PIs are encouraged to examine these to find the appropriate program for submission. Proposals with a heavy emphasis on tissue engineering or developing validated models of tissue and organ systems should consider the Engineering of Biomedical Systems (EBMS) program.Projects addressing biological questions about the physiological mechanisms and structural features of organisms should consult the Physiological Mechanisms & Biomechanics (PMB) program.Projects elucidating aspects of neural control may consider the Perception, Action, & Cognition (PAC) program or the Mind, Machine, and Motor Nexus (M3X) program if the project contains work relevant to human-machine interaction. Projects in rehabilitation engineering should consider the Disability and Rehabilitation Engineering (DARE) program. Projects focused on fundamental research related to design, characterization, and modification of biomaterials should consider the Biomaterials (BMAT) program. Manufacturing systems proposals should consider the Advanced Manufacturing (AM) program. Work on the interplay between structure, dynamics, and function of biomolecules without advancing our understanding of the mechanics of a living system should consider the Molecular Biophysics program. Researchers who believe their work may span multiple programs are particularly encouraged to contact the cognizant program directors well in advance of submission. The duration of unsolicited proposal awards is generally up to three years; proposals for a shorter duration are welcome. Single-investigator award budgets typically include support for one graduate student (or equivalent trainee) and up to one month of PI time per year (awards for multiple investigator projects are typically larger). Proposal budgets or durations that are much larger than typical should be discussed with the program director prior to submission. Proposers can view budget amounts and other information from recent awards made by this program via the “What Has Been Funded (Recent Awards Made Through This Program, with Abstracts)” link towards the bottom of this page.

The Established Program to Stimulate Competitive Research (EPSCoR) is designed to fulfill the mandate of the National Science Foundation (NSF) to promote scientific progress nationwide. NSF EPSCoR facilitates the establishment of partnerships among academic institutions, government, industry, and non-profit sectors that are designed to promote sustainable improvements in an EPSCoR-eligible jurisdiction’s research infrastructure, Research and Development (R&D) capacity, and R&D competitiveness. Eligibility to participate in NSF EPSCoR funding opportunities, including the EPSCoR Workshop Opportunities program, is described on the EPSCoR website (see criteria for eligibility link ). EPSCoR welcomes proposals for workshops only from institutions within EPSCoR-eligible jurisdictions (i.e. states, territories, commonwealths). These workshops must focus on innovative ways to address multi-jurisdictional efforts on themes of regional or national importance with relevance to the goals and mission of NSF and EPSCoR .

The objective of this Agreement is to advance historic preservation at the local level by establishing a task agreement between the National Park Service and the National Alliance of Preservation Commissions (NAPC) to provide training opportunities, promote the Federal Certified Local Government program, and strengthen local preservation commissions by providing bi-annual State Certified Local Government Coordinator Training

*Task agreement already awarded to SCA for the work described.